About Products Protein Database Contact

NUDT16L1

Gene
NUDT16L1
Protein
Tudor-interacting repair regulator protein
Organism
Gallus gallus
Length
314 amino acids
Function
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin.
Similarity
Belongs to the Nudix hydrolase family. TIRR subfamily.
Mass
33.296 kDa
Sequence
MGVMAAVGALPAGAGSLPPLPTLGVPGVPELKPLTRYEAMRLGPGWSHSCHAMLYAPNPGMLFGRIPLRYAVLMQMRFDGLLGFPGGFVDRRYWSLEDGLNRVLGLGLGCVRLTEADYLCSHLTDGPHRVVAHLYARQLTLEELHTIEISAVHSRDHGLEVMGMVRVPLYTQKDRMGGLPNFLANSFVGTAKFQLLFALKILNMVPEEKLAEAVAATQKPKKPAIDHAAVAAAKQANELAAAARAGNEYADSGENQAAAHAAAELAEQQAAGLESQAVLEHLAAVPGAEAVVAELHAQPGADAVLEQPVAEAME

Gene
NUDT16L1
Protein
Tudor-interacting repair regulator protein
Organism
Homo sapiens
Length
211 amino acids
Function
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).
Similarity
Belongs to the Nudix hydrolase family. TIRR subfamily.
Mass
23.338 kDa
Sequence
MSTAAVPELKQISRVEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKCQLLFALKVLNMMPEEKLVEALAAATEKQKKALEKLLPASS

Gene
Nudt16l1
Protein
Tudor-interacting repair regulator protein
Organism
Mus musculus
Length
211 amino acids
Function
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA.
Similarity
Belongs to the Nudix hydrolase family. TIRR subfamily.
Mass
23.414 kDa
Sequence
MSTTTVPELKQISREEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGGLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKYQLLFALKVLNMMPSEKLAEALASATEKQKKALEKLLPPSS