Protein
Neurotoxin 8-related gene product 1/2/3
Organism
Androctonus mauritanicus mauritanicus
Function
Binds voltage-dependently at site-3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Similarity
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
Sequence
MNYLTMISLALLVMTGVESGVRDAYIADNKNCIFTCYRDSYCKTECIKNGAETGYCIWIGEYGNACWCIKLPNKVPIKVPGKCNGR