ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

224 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.

Belongs to the methyltransferase superfamily. NTM1 family.

25.458 kDa

MSTELVEDEAQFYCKAQKYWKNVPATVDGMLGGYGHISNIDLNGSKKFLQRFLRQEGSNKTGNMYALDCGAGIGRITKRLLLPLFKKVDMVDVTDEFLSKAKSYLGEEGSRVGNYFCCGLQEFSPEPNRYDVIWIQWVIGHLTDEHLVDFLKRCSLGLRPNGIIVIKDNVTQDVSIMDDVDSSICRDIDLVRKLIKQAGLSLLAVERQENFPDEIYHVFSFAMR

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Belongs to the methyltransferase superfamily. NTM1 family.

25.284 kDa

MTSEVIEDEKQFYLKAKTYWKEVPPTVDGMLGGYGHISSIDISSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFGVVDMVDVTEDFLIKARTYLGEEGKRVRNYFCCGLQDFSPEPNSYDVIWIQWVIGHLTDQHLAEFLRRCKQGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVHRIVRSAGLSLLAEERQENLPDEIYHVYSLALR

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Belongs to the methyltransferase superfamily. NTM1 family.

25.289 kDa

MTSEVIEDEKQFYSKAKTYWKEVPATVDGMLGGYGHISSIDINSSRKFLQRFLREGQNKTGTSYALDCGAGIGRITKRLLLPLFGVVDMVDVTEDFLVKAKTYLGEEGKRVRNFFCCGLQDFSPEPQSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRALDVVHRIVRSAGLSLLAQERQENLPDEIYHVYSLALR

ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.

Belongs to the methyltransferase superfamily. NTM1 family.

25.265 kDa

MEDCLIEDQTSFYSEAEHYWKDVPPTVDGMLGGYGSISSIDINGSKKFLQKFLGEGQGKTGTGCALDCGAGIGRITKRLLLPLFRTVDLVDVTQEFLDKARTYLGEESKRVENYFCCGLQDFQPQPERYDVIWIQWVIGHLTDDHLVEFLRRCRSGLRPEGLIVVKDNVAYEGVIPDDVDSSVCRDLNVLHRLVARAGLSIIYEEQQQNFPEEIYQVHALALR

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Belongs to the methyltransferase superfamily. NTM1 family.

25.387 kDa

MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR

Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (PubMed:20668449). Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1) (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 (PubMed:20668449).

Belongs to the methyltransferase superfamily. NTM1 family.

25.42 kDa

MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCGLQDFSPEPGSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPDEIYHVYSFALR

Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

223 amino acids

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Belongs to the methyltransferase superfamily. NTM1 family.

25.464 kDa

MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCGLQDFSPEPSSYDVIWIQWVIGHLTDQHLAEFLRRCRRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRSAGLSLLAEERQENLPDEIYHVYSFALR