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NSUN3

Gene
nsun3
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Organism
Danio rerio
Length
367 amino acids
Function
Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
41.27 kDa
Sequence
MSGSSFLFLKSIKCILSSSCHGQNTISNTQLAAQYISKPQKQLCETVLKYFDRQYSEELGEQWWNARDVLLNPLSWQYGVLLNRFSDLTNLKQCLAELGYTNLLQQTHPESHSQTADIPLQCFIHPDPVRIPTQSHHTGWLKQYYLLNAASLLPVLALNVQEGENVLDLCAAPGGKSLAILQTATPGLLHCNEVDQHRHDWLLKTLESYVPPSLRHLLSVTLQDGRSIGTMQPGAYDKVLVDAPCSNDRSWLYTPDTHRGEMWLKERTQLPLLQKELLCSALAAVRPGGIVVYSTCTMSRAENQSVVEEVLASYPGVELQELEQQFIDSLSDHFCFAHLHPSVGQLVIPQKGKTWGPMYVSQLKKIY
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial: nsun3

Gene
Nsun3
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Organism
Mus musculus
Length
348 amino acids
Function
Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
39.182 kDa
Sequence
MLTRLKAKSEGKLAKQLCRVVLDQFDKQYSKELGDSWSTVRDVLISPSLWQYAILFNRFNYPFELEKALHLRGYHTVLQGALPHYPKSMKCYLSRTPDRMPSERHQTGSLKKYYLLNAASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPGYLLCNEYDRPRGRWLRQTLESFIPQPLINVIKVSELDGREMGDAQPATFDKVLVDAPCSNDRSWLFSSDSQKAAYRIHQRKNLPVLQVELVRSAIKALRPGGLLVYSTCTLSKAENQDVISEVLTSDSNIVPVDISGIARTFSQDFTFAPTDQKCSLLVIPEKGKAWGPMYIAKLKKGMSTRKRQGEFCKPC
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial: Nsun3

Gene
NSUN3
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Organism
Homo sapiens
Length
340 amino acids
Function
Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
38.244 kDa
Sequence
MLTQLKAKSEGKLAKQICKVVLDHFEKQYSKELGDAWNTVREILTSPSCWQYAVLLNRFNYPFELEKDLHLKGYHTLSQGSLPNYPKSVKCYLSRTPGRIPSERHQIGNLKKYYLLNAASLLPVLALELRDGEKVLDLCAAPGGKSIALLQCACPGYLHCNEYDSLRLRWLRQTLESFIPQPLINVIKVSELDGRKMGDAQPEMFDKVLVDAPCSNDRSWLFSSDSQKASCRISQRRNLPLLQIELLRSAIKALRPGGILVYSTCTLSKAENQDVISEILNSHGNIMPMDIKGIARTCSHDFTFAPTGQECGLLVIPDKGKAWGPMYVAKLKKSWSTGKW
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial: NSUN3

Gene
NSUN3
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Organism
Bos taurus
Length
338 amino acids
Function
Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
38.384 kDa
Sequence
MVLTLLKAKPERKLAKQICKVVLDHFEKQYSKELGDAWNTVRDILTSPSCWQYAVLLNRFNYPFELEKDLHLKGYHSLLQGSLPYYPKSMKCYLSRTPHRMPSERHQTGNLKKYYLLNAASLLPVLALELRDGEKVLDLCAAPGGKSLALLQCAYPGYLHCNEYDSLRLRWLRQTLESFIPQPLVNVIKVSELDGREMGDAQPETFDKVLVDAPCSNDRSWLFSSDSQKAACRISQRRNLPLLQMELLRSAIKALRPGGLLVYSTCTLSKAENQDVISEVLNSYSNIMPVDIKEMARTCSRDFTFAPTGQECGLLVIPDKGKAWGPMYVAKLKKSWTT
Protein
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial: NSUN3