Protein
Inosine-uridine preferring nucleoside hydrolase
Function
Catalyzes the hydrolysis of the N-glycosidic bond of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. Likely functions in purine salvage from the host, a fundamental pathway since protozoan parasites such as L.major are incapable of de novo purine biosynthesis.
Similarity
Belongs to the IUNH family.
Sequence
MPRKIILDCDPGIDDAVAIFLAHGNPEIELLAITTVVGNQSLEKVTQNARLVADVAGIVGVPVAAGCTKPLVRGVRNASHIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMGGGYHTGNASPVAEFNVFIDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVREVGTKPAAFMLQILDFYTKVYEKEHDTYGKVHDPCAVAYVIDPTVMTTERVPVDIELNGALTTGMTVVDFRYPRPKNCRTQVAVKLDFDKFWCLVIDALERIGDPQ