About Products Protein Database Contact

NSMCE4A

Gene
NSMCE4A
Protein
Non-structural maintenance of chromosomes element 4 homolog A
Organism
Homo sapiens
Length
385 amino acids
Function
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.
Similarity
Belongs to the NSE4 family.
Mass
44.301 kDa
Sequence
MSGDSSGRGPEGRGRGRDPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA

Gene
NSMCE4A
Protein
Non-structural maintenance of chromosomes element 4 homolog A
Organism
Bos taurus
Length
382 amino acids
Function
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).
Similarity
Belongs to the NSE4 family.
Mass
43.728 kDa
Sequence
MSGDSSGRRPEGRGRGRDPHRDRTRSRSRSRSPLSPGSRRGAAPERREAPERPGLEDTEPSDSGDEMIDPASLEEETDPSLCRQIRHQYRALINSVQQNREDILNASDKLTEVLEEANTLFNGVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLNSFDMLRYVETLLTHMGVNPLEAEELIRDEDSSDLEFIVYDSWKISGKTAENTFNKTHTFHFLLGSIQGECPVPKPRIERPRKVRMIEEQQAMPAQLKRMEESHQEATEKEVERILGLLQTYFQEDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDRDRLPVIEPVNINEESGGNTQIRNQAIIALSYRDWEEIVRTFEISEPVITSSQSQQRLSA