About Products Protein Database Contact

NSFL1C

Gene
nsfl1c
Protein
NSFL1 cofactor p47 homolog
Organism
Dictyostelium discoideum
Length
415 amino acids
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Regulates the centrosomal levels of kinase aurK/Aurora during mitotic progression by promoting aurK removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
45.471 kDa
Sequence
MSDHSEAIATFQSITGASKEESTFYLESHDWDLEKAAQTFTTLQEEENQRNDQPQIEEDYEDEEEEDDHRDPMPASRPVYSKPVAKTVSKKAPAGGRVGGIRTLSDFNNDDHDDHDHSDGDDDEDDRSQQYFTGGEKSGLVVESAPKKGKNGGSGDIVNDVFDSAKRHGAVASNEKKVEKPDSFDSVGYQLGATDQGNRNVSKPKEKDPNSQVVEVKVTFWNQGFTIDDGPLRKYDNPENKELLDDIQRGIVPRELQKKATTPNGLSVTLINNHNQDYVEPAKPKYVAFSGGGQTLGSSSTSTNNNNNNNNNNNNRATTTSTTTTSTPNVSSINVDQSQPTTTVQIRLANGSRLSTTFNHSHTLQDVINYINSSSGSNQSFDLLTGFPQKPVTNPTSTTLKDAGLLNALLIQKLK

Gene
NSFL1C
Protein
NSFL1 cofactor p47
Organism
Bos taurus
Length
370 amino acids
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Mass
40.654 kDa
Sequence
MAAERQDALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEDEEEEEGQRFYAGGSERSGQQIVGPPRKRSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGELRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQILNTSSPAQQAENEAKASSSISIDESQPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFVLMTTFPNKELADENQTLKEANLLNAVIVQRLT

Gene
NSFL1C
Protein
NSFL1 cofactor p47
Organism
Homo sapiens
Length
370 amino acids
Function
Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).
Similarity
Belongs to the NSFL1C family.
Mass
40.573 kDa
Sequence
MAAERQEALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEDEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGEKRQHSSQDVHVVLKLWKSGFSLDNGELRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSSILIDESEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFILMTTFPNKELADESQTLKEANLLNAVIVQRLT

Gene
Nsfl1c
Protein
NSFL1 cofactor p47
Organism
Mus musculus
Length
370 amino acids
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
40.71 kDa
Sequence
MAEERQDALREFVAVTGTEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEEEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGDLRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLNTSSPAQQAENEAKASSSILINEAEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFVLMTTFPNKELADENQTLKEANLLNAVIVQRLT

Gene
NSFL1C
Protein
NSFL1 cofactor p47
Organism
Pongo abelii
Length
370 amino acids
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
40.573 kDa
Sequence
MAAERQEALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEDEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGEKRQHSSQDVHVVLKLWKSGFSLDNGELRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSSILIDESEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFILMTTFPNKELADESQTLKEANLLNAVIVQRLT

Gene
Nsfl1c
Protein
NSFL1 cofactor p47
Organism
Rattus norvegicus
Length
370 amino acids
Function
Reduces the ATPase activity of VCP (PubMed:9824302, PubMed:9214505). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (PubMed:12411482). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (PubMed:10930451). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity).
Similarity
Belongs to the NSFL1C family.
Mass
40.68 kDa
Sequence
MAEERQDALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEEEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGDLRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLNTSSPAQQAENEAKASSSILINEAEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFVLMTTFPNKELADENQTLKEANLLNAVIVQRLT

Gene
NSFL1C
Protein
NSFL1 cofactor p47
Organism
Gallus gallus
Length
369 amino acids
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
40.641 kDa
Sequence
MADREEALREFVAVTGAEEERARFFLESAGWDLQIALASFYEDGGDEDILTLPQPTPSSVSRGTAASDHRVTSFRDLVHAQEDDDEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVEDLFKGAKEHGAVAVDRTAKSSGESSKPKPFAGGGYRLGATPEEESAYVAGERRHNSVQDVHVVLKLWKTGFSLDSGELRSYQDPSNAQFLDDIRRGEVPAELRRLARGGQVNLDMEDHRDEEYVKPKSVFKAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSAIAIDESEPVTNIQIRLADGGRLVQKFNHNHRIRDIRLFIVDARPAMAATSFVLMTTFPNKELTDENQTLKEANLLNAVIVQRLT