Protein
Nonribosomal peptide synthetase 13
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Catalyzes the condensation of L-tryptophan and L-proline to produce brevianamide F, the first step of verruculogen biosynthesis pathway. Brevianamide F is the precursor of a variety of fungal prenylated alkaloids with biological activity, including fumitremorgins A, B and C and tryprostatin B. Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence (By similarity).
Similarity
Belongs to the NRP synthase family.
Sequence
MALAVAAPSEWRGILPYNTSKDSPTVHSMKVATDVKNEQGEFGFWDTCVHTVVREHCQRSPDSPAVNAWDGSFTYAELDSLSDAIASVLILFGVKPESIIPIYMHKSRWTTVAILGVLKSGGAFTLLDPSHPRSRLEEICKEIQARFILTSEELSKQCSEMSSVLVVEHLSRACLLSPGQAGQTPSRPENAAYIAFTSGSTGKPKGIVIEHRSYCSGARSHLKVFGIDSTSRVLQFASYAFDVSIMETLSTLMAGGCLCVMSESERSDPNLFVESYKNFRISHCFMTPSFARTVQWTECCNPPPTLIVGGELMRPSDTRAYKAMGICCMNAYGPAECSVNVSVQSRVEDGVDPRNIGYTTGATAWIISPENPEQLMPPGTVGELLVEGPIVGRGYLNDPSATRQAFIDTPGWLRRHRKGTSYQHRVYRTGDLASQDSISGALLLHGRKDAQVKIRGQRVELPDIEHHLQQTLPDGDAEVIVEKVTFSDDGAEKLIAFVLIPPSSTGFITDNMGDRLFLAPQSQIMEQFAISKKHLQTNLPSYMVPDIFIPISTIPQTVSGKTDRKALRTRAAALSRRDVQCYLLSPTGDKRPPSTLKETTIRSLYSKVLNLPIDLIGMDDTFLRLGGDSLQAIRLVAAARTAGLVLHAKDILSSQSTLAEQSQRAGLIQTSDHTGEASTPFALLPVATRHDIVDLAQKQCRVSSKLIEDIYPCTALQEGMFMTSLRHPGMYTGQITFDIPDRMELPRLRAAWLSVVSKNAALRTRIIETHEGLMQAVIVDDFAWEEETDEMLPSGRWEVLEITKIGVPLVRFRYRPRHRQLIMTIHHSIWDGWSLRLVHEQLQRAYIGRDPLPSTSYRSFIQYGQDLPGADEFWASELAGVNAPIFPTLPSGNYRPCVNASHRHGVRKLVSTGRGEHTAATYIHLAWSLLVAHYTDADETVYGVTVNGRSADVPGIENIVGPTIATVPLRIRVNQEDTVKMALDQVQDSLARMIPYEQAGLQRISRCSRDASEACRFQTLLIIEAPADRDVACEKNEAKNFSIIRGTTQTGMDYTAFSPYAMMLIFRTSADKSAITLDITYDAQVIGCVEVERMAHQFEHVLRHIYKRATGRIGDISFLGPRDIEQVQQWNSYMPPADNRFLQELIFARCSRRPQASAIISWDGSWTYRELWAHSSFFARQLQRYGVTRGTPVAVCLDRSRWSIAVILAVLLAGGTCVLIDLLSPRQRVRDILQIVGAGIMVNSHATAPVTSGLCPTVIDVSLLVAQNDDSQTECPFNLDTWERGVGTPEDLAFIMFTSGSTGHPKGIEMPHRTLSTSIYHHSAGMKVKSSSRVLHFSSYAFDVSIYEIFTTLAAGGTICVPSEFDRMNNLSGFIQDTQVNWAFLTPSTARSLDPADVPLLTTLVLGGEAVTHESVEAWAKGRSLINGYGPAEATICGVGNIPEAGWKSGVIGQIVGGLGWVTVPSDPNRLAAVGAVGELLLEGPFLARGYLNLPEVTRAAFIDPPSWRTQIPAPSPYPFLYRTGDLVQYQPDGSIQYIGRKDSRIKLRGQLVDLSAVEASLMRVYPAAIQVVADVLVSENTTRLIAMMKLGPPVTETHDDPLFEAPDLAFNEAAASVQARLRAIVPPYMVPSMFIPLRHIPRTLTGKTDRRQLRDKLLSLSQSDLQRYIMSSSAKTPMSDDNERRLQEIWAEVLQLPCEAIGREDSFLLLGGESLATMKMVALARRVGFVFAVADVLNNTSLSTLAQFRHLITEDDIPSPSPSLSLSTIESQSLQKILRPLQNGGLIQGGNDIAAIHPVTAAQAFLVQRYPWSHFQFDLSGAISPSKLQTACTTLMARFTILRTVFVEHAGHLLQLVLREVRKCVHEITTDEPLDDFCNSLCQQQQGVCVVNSTALPTLFTLVSNRQLNRHRLLLRLAHAQYDLTTIPLIVQALADEYNGTLRAGFSSDFSYYLNHHMRQTNDDRAHTFWNQYLSGSFMTSTDQTADTTTPQERIFHVTGSCTVTPASHPLGITTATAVKAAVCLVLASRTGCTDIVVGQTVDARCSSADGTLDQIVGPCTNYIPYRLSVCCSKTALEYLCSAQAQHTTSLRYSSLDLDQIVAKCTSWPSSTQFGYIVQHQNTGADLALSLAGCTTSSPMTSYGHVFPQGEVWIGSTPYSTGLKIDVIAPSAVLSQEDAQAMAGEVGAALENLLACGDRPLSDLIGNTFAT