nrp1

Neuropilin-1

928 amino acids

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (By similarity). Presumed to be involved in the neuronal recognition between the optic nerve fibers and the visual centers.

Belongs to the neuropilin family.

103.416 kDa

MLLRLLSCCCWLLCSLRSSWASRNDKCGDTIKITSPSYLTSAGYPHSYPPSQRCEWLIQAPEHYQRIMINFNPHFDLEDRECKYDYVEVIDGDNANGQLLGKYCGKIAPSPLVSTGPSIFIRFVSDYETPGAGFSIRYEVFKTGPECSRNFTSSNGVIKSPKYPEKYPNALECTYIIFAPKMQEIVLEFESFELEADSNAPGGQTCRYDWLGIWDGFPGVGPHIGRYCGQNTPGRVRSFTGILSMIFHTDSAIAKEGFFANFSVVQSNTDEDFQCKEALGMESGEIHFDQISVSSQYSMNWSAERSRLNYVENGWTPGEDTVKEWIQVDLENLRFVSGIGTQGAISKETKKKYFVKSYKVDISSNGEDWITLKDGNKHLVFTGNTDATDVVYRPFSKPVITRFVRLRPVTWENGISLRFELYGCKITDYPCSRMLGMVSGLISDSQITASSQVDRNWVPELARLVTSRSGWALPPSNTHPYTKEWLQIDLAEEKIVRGVIIQGGKHKENKVFMRKFKIGYSNNGTEWEMIMDSSKNKPKTFEGNTNYDTPELRTFAHITTGFIRIIPERASASGLALRLELLGCEVETPTSIPTTPEVNGGDECEGDLANCHSGTDEGFKLTVGATGQSTETPTVEASPEEPDMTHSDLDCKFGWGSQKTVCNWQHDISSDLKWAVLNSKTGPVQDHTGDGNFIYSEADERHEGRAARLMSPVVSSSRSAHCLTFWYHMDGSHVGTLSIKLKYEMEEDFDQTLWTVSGNQGDQWKEARVVLHKTMKQYQVIVEGTVGKGSAGGIAVDDIIIANHISPSQCRAPEIDDSANKIGEEDSEIDKTGSTPNYALNEFNESISKKPGNVLKTLDPILITIIAMSALGVLLGAICGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQNSYSEAS

NRP1

Neuropilin-1

923 amino acids

The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Belongs to the neuropilin family.

103.134 kDa

MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA

Nrp1

Neuropilin-1

923 amino acids

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).

Belongs to the neuropilin family.

103 kDa

MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA

Nrp1

Neuropilin-1

922 amino acids

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. Regulates VEGFA-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).

Belongs to the neuropilin family.

103.082 kDa

MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA

NRP1

Neuropilin-1

914 amino acids

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (By similarity). Seems to have calcium-independent cell adhesion properties.

Belongs to the neuropilin family.

102.48 kDa

MDWGLFLHCAALTFTLSRALRSDKCGDTIKILSPGYLTSPGYPQSYHPSQKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGDNAEGRLWGKYCGKIAPPPLVSSGPYLFIKFVSDYETHGAGFSIRYEVFKRGPECSRNFTSSSGMIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFELEPDSNTPGGAFCRYDRLEIWDGFPDVGPHIGRYCGQNNPGRVRSSTGILSMVFYTDSAIAKEGFSANYSVSQSSVSEDFQCMEPLGMESGEIHSDQITVSSQYSAIWSSERSRLNYPENGWTPGEDSVREWIQVDLGLLRFVSGIGTQGAISKETKKEYYLKTYRVDVSSNGEDWITLKEGNKPVVFQGNSNPTDVVYRPFPKPVLTRFVRIKPVSWENGVSLRFEVYGCKITDYPCSGMLGMVSGLIPDSQITASTQVDRNWIPENARLITSRSGWALPPTTHPYTNEWLQIDLGEEKIVRGIIVQGGKHRENKVFMKKFKIGYSNNGSDWKMIMDSSKKKIKTFEGNTNYDTPELRTFEPVSTRIIRVYPERATHAGLGLRMELLGCELEAPTAVPTVSEGKPVDECDDDQANCHSGTGGTTVLNTEKPTVIDNTVQPELPPYNLNCGFGWGSHKTLCQWEHDNQVDLKWAILTSKTGPIQDHTGDGNFIYSQADESQKGKVARLLSPIIYSQNSAHCMTFWYHMSGPHVGTLKIKLRYQKPDEYDQVLLSLNGHQANCWQEGRVLLHKSVKLYQVVIEGEIGKGNGGIAVDDINIDNHISQEDCQKSTDVESEIVEEDPESNQTGFTPSYRTDEDYDDISRKPGNVLKTLDPILITIIAMSALGVLLGAICGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQNSYSEA

NRP1

Asparagine-rich protein

719 amino acids

79.299 kDa

MHYVVLELQVAHLPDTPKDQCRIANIAFQIVNAETLVCHYGTNSLPSIEVNGTTKSLESAMVQLDKDIHDVIGNDDFVLVSLYSTWHIRVTLPRQARDDGFILTSYLQHPKVFDLWKEFDRWCVNHPEILGQKKAISNNNCNTKSISINAAKNTKDLDEIVRILEVSIPTEEAGSVPEIYSLLKRTTDILIQLHKKCTSPEDMESVLTKPYDSHTDIRAFLQEKSKILYMNNLPPDTTQSELESWFTQYGVRPVGFWTVKNIVEDTSNVNNNWSLNNSPYVEDQDSISGFVVFQTHEEATEVLALNGRSILSNLANTKQPRVVEHVLELQPSSTGVLDKAQEILSPFPQSKNKPRPGDWNCPSCGFSNFQRRTACFRCSFPAPSNSQIHTANSNNNVNSSRNNLNNRVNSGSSSNISNTAANHPYGAPEFNMIANNTPAALTYNRAHFPAITPLSRQNSLNMAPSNSGSPIIIADHFSGNNNIAPNYRYNNNINNNNNNINNMTNNRYNINNNINGNGNGNGNNSNNNNNHNNNHNNNHHNGSINSNSNTNNNNNNNNGNNSNNCNSNIGMGGCGSNMPFRAGDWKCSTCTYHNFAKNVVCLRCGGPKSISGDASETNHYIDSSTFGPASRTPSNNNISVNTNGGSNAGRTDGNDNKGRDISLMEFMSPPLSMATKSMKEGDGNGSSFNEFKSDKANVNFSNVGDNSAFGNGFNSSIRW

NRP1

NAP1-related protein 1

256 amino acids

Acts as histone H2A/H2B chaperone in nucleosome assembly, playing a critical role for the correct expression of genes involved in root proliferation and patterning. Required with NRP2 for the maintenance of cell proliferation and differentiation in postembryonic root growth. Involved in both intramolecular and intermolecular somatic homologous recombination.

Belongs to the nucleosome assembly protein (NAP) family.

29.416 kDa

MVADKSKKSKIEEKGEEENLEQIDAELVLSIEKLQEIQDDLEKINEKASDEVLEVEQKYNVIRKPVYDKRNEVIQSIPGFWMTAFLSHPALGDLLTEEDQKIFKYLNSLEVEDAKDVKSGYSITFHFTSNPFFEDAKLTKTFTFLEEGTTKITATPIKWKEGKGLPNGVNHDDKKGNKRALPEESFFTWFTDAQHKEDAGDEIHDEVADIIKEDLWSNPLTYFNNDADEEDFDGDDDGDEEGEEDDDDEEEEDGEE

NRP1

Nodulin-related protein 1

187 amino acids

Prevents accumulation of abscisic acid (ABA) after heat treatment, thus reducing thermotolerance. May be a negative regulator of the ABA signaling/synthesis pathway (PubMed:20016941). Required for defense responses against avirulent bacteria such as P.syringae pv. tomato DC3000 (avrRpt2) (Ref.5).

19.701 kDa

MDFFTDQVKKKFSDKKPESSDPEPNHNKNKPGHTEPTTHKPGHGEPTTHKPVSNTDPTTHRPATNAELMASAKIVAEAAQAAARHESDKLDKAKVAGATADILDAASRYGKLDEKSGVGQYLEKAEQYLHKYETSHSHSSTGGTGSHGNVGGHGGGAGAPAAKKEDEKSGGGHGFGDYAKMAQGFMK