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NPS6

Gene
NPS6
Protein
Nonribosomal peptide synthetase 6
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
2071 amino acids
Function
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).
Similarity
Belongs to the NRP synthase family.
Mass
228.31 kDa
Sequence
MTELDLSAEPNVPQTKTVRHNVPVLRKHHEQDAQELEILLLAWSLLLYRHNHGNHVEFSWGLTEIGSSTCRTFTLNTAKLQWDGSNIVASELEVFKTYTQQQLQSEVPFKRDQYKLFFNDEPATGDLVNYITEDGDISVNWGNVQIQATLVDDALCLRPTWREPLGAEFLANHLAQAFVEVLNTTLADPDATLSSVLPLGKLDKSVIWNWNKDLPPPVPECIHTLISEQVRLRPDAQAICSWDGDLTYAEMDNLSTLLAQHLINLGVKNGDIVPLCFEKSRWTTVGVMGVIKAGAAFVLMDPSQPIQRRQVMAQQVKATHILTSRDQAKYGPEIAPEAKHVIVDTETLDSLAKTIEDPSRELPQVPPESLLYIIFTSGSTGTPKGVMLSHETYTASALARSTGIGYSSISRSLDFTSYAFDVSIDSILCTLIRGGCLCIPTDMDRVNDLSGAIRRLKVNMVNITPSVARILDPDIIPSLNSLGIGGEACSAGDIAIWGQHTRIVIGYGPAECTIGCTVNPSAAGKPYVSMGPGTGACIWLVDPDDHNKLVPVGAVGELLIEGPIVGQGYLGDPEKTKEAFISDPDFLLAGADGIPGRQGRLYKSGDLVRYDPDGENGFIFVGRKDTQIKLRGQRVELGEIEHHIKNLLPSGAEVVAEIIAPRNQNKESMLVAFVADREAKDEGDARQIDFPPRFREALEVLNDKLSKVVPVYMVPTQYITLSKIPYLVSGKTDRKSLRALGAEISANMQASAAANESSEIREPQSEAELFLRDSWCRLLGLENKQVSTTHNFFTSGGDSVLAMKLVPIVRDWGYTLSVADIFNYPVLSDMANSMQKGDSSKGVDMQIPEFSLLKDDMDREALCAEAAHNSGCDVSAIEDIYPCAPMQEIHMAFYTRSKENYVAQRIADIPASSSIDKLKSAWNVVYKESPILRTRIVEFKQHGFMQVVVNEALQWEEVDSSLEDFIEKDKKESMSPGAPLSRFAIVTDKALDKRYFVWTAHHAIYDGWSTDLIVEHARAAYKGQEVSRPAQFKHFIRYLAEDSRESSKAYWKTQLAGATGPQFPSLPSRSYIPDPTSLTERFIKLDKAAKSDITIATVIRAAWALLASQYSMSDDVVFGETFMGRTIPLPGAELIEGPILATVPVRIRLDLTTTVQDFLRAVQEQSVKRAAHEHLGIQHIRRLSDDAQIACEVTMGLVVQPQDPDPTETENDALPSFRGGDAALEALHFNSYPLMLAVSMQKTGFRLLASFDSELLSHVQVERVLSQFEVAINQLRGDMSRSLNELTCLGEEELGQIWEANKHAPVSPKDISRFLSTGDKYPTVQYVPWVVQPGNEKLLMPLGSTGELLLEGIASAGDDDDVVDAPEWLKEGAMGYPGRQGKLVRTGDLVKYADDMSLVFIGRKDAMTSVDGRVVDLNATNIELNRLLPSNTKAVSRLVVPKGSNSQTPVVVALVQETSAKDTQLLKLGLDISDASMPLSQAVSVELATAIIGLNKAMVETLPPYAIPSICIPLDNSADIDSIDTIVENITLSLVVELRKSFASLKKTIADTTVLTTKERVLRASWSKFLGIEEEKLALDDNFFRLGGDSIVAMRMVSALRQDGYRLSVASIFQNMQLRGMADSLAEISTESVEAAKEYTAFSMLDTNDVDSFLAKVIRPQLADPKWKIKDVLHATGPQAGDVKQSVFAPRSSVQYNMLYLDQSIDTARLVDSFQYLVSQHAILRTVFVENEGQTLQVVLDDLKVPVTEQNVEGSIDAAAKQLAVSDINSSIDLTHGSSFIRLFVLRGESENALVIRISHAQYDGVSLPELLRQLELRYRGLEIPSSEPFETYIQHLSAAKPQNVEFWRKTLQGSSYTEIAPAADPQKKTAFMTKDVDISGASPNTTHAMLLTAGWAKVLSQHLNVSDVTFGGIVSGRDVDVAGIDTIMGPCYQYQPVRVKFESNWTATDLLDSVRSQSLEGSQRATLSFQEVLKECTNWPAGTPFYGSFTNHLNKEFFDSIPFAGTKCRVDYSIPHPEPATPPRVVSFLEDGRTQIGIEADEERREFWEARLGELAKVIEGFVKNPQALI

Gene
NPS6
Protein
Nonribosomal peptide synthetase 6
Organism
Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)
Length
1761 amino acids
Function
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:15755917, PubMed:17056706, PubMed:23980626). Cochliobolus heterostrophus produces extracellular coprogen-type siderophores including coprogen, neocoprogen I and neocoprogen II, as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17601875). SIDA2 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:23980626). The assembly of extracellular coprogen-type siderophores is then performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17601875).
Similarity
Belongs to the NRP synthase family.
Mass
194.461 kDa
Sequence
MARHQAVSQLHFFALILESLFKGADHPLSHFHNVSEDELDELWSWNTPLQPELRFCMHEKVSERAALHPEKIAIDAWDGTLTYGQIEDYSDKLAKLLRLLDDSSNRIIPVLFEKSRWTSVAVLAIMKSGACFALLDPAQPEGRLRAVVQQVNAKIFLSSKAQSTLAARVAPAATIIPISKSKFNKIFSPYTAEQPNTTLPPVSPDQPLYIQFTSGSTGVPKGCILTHSQYTSGAIPRAAAVGYYPHSRVLDFASYAFDVCIDSMLCTLAHGATLCTPSDERRMNDMSGAMRDMQVTFAGMTPSVARTLEVDILNNLESIALGGEGVSISDAMSWGQRTRVVNAYGPSEATVGATINDNVAAKPYITMGKRKGCALWLSDPENHNKLVPVGAVGELLIEGPIVGNGYLNNPSKTKEVFIEDPEFLLKGSKSYPGRHGRIYKTGDLVRFDPDGDGEPIFVGRQDQQVKLRGQRIELAEIEFNMQKHLPPDTQLAAEVIKPSGGGEQTLVAFLVEQKKNGMRHLDGNVFGSFTNKFQDALRDMTKQLFVDLPSYMIPSAYIPLWKMPLLVSCKTDRKRLREIGASVTRQDLRRFNSAVSEKKEATTEMELKLQSLWAKLLGGDADFSANDNFFSMGGDSLRAMRLVAAARDEGVVLSVPDIMLNPTLSSMAEKAKPVSAEETSDVPPFSMIAKDWDVDAARQESARLCGVDVANVEDVYPCTPLQEGLIALSAKFQDAYVAQRVATLPAETAVRLKEAFDTAVQGSPILRTRIINVSGRGLFQVVLKDGQLVREYSTEVSEYLRLDRNEPMDLGTALFRYGLVEEPGSDKMNFVITMHHAVYDGWSMPLVFDRVNRAFNGLHTERPSSFKHFIKHLISLDPADAQQYWKERLEGTIPHQFPPLPQKGYTTQADSLLEHYVTVPTSAHSKLTLATIIRGAWALVSSLYMGHPDIVFGETLTGRSAPVPGIEQIEGPMITTVPIRVRLSLDRPIAEYLQKIHAQTVKQIPHEHLGLQNIRRLSKDARVACDLRTGLVLHPKEDEDWGTVDIRNPANTFLPANDAEGAREALKFNTYALMLVCTLEENGFLVMASFDSNCISKEAMERVLAVLDRIVHAFLGNPESKLGDVAVLDPVEAQDAEAMRPRDVMSDSALGMSPVDGPESMDASLKELSPNEEKLRSILGRILGMKETDIRPSDSFFDLGGDSIGAMRLVSDARAQGLNLTVAQVFQSSSLSDLAASASNEREDKLAEILSRILGMAKTDIKSSDSFFELGGDSIGAMRLVSDARAQGLNITVAQVFQSKSLAELASSAEEETPSQPRVDTDAPFIALGKDANLHSPDRVGLYLENQGWEITNIYPTRPLQQLAVEGTVDLPRYSLRYELIKFATPIDRQRLEQACQELVARNEVLRTVFVKDDGLTLGVVLSSLVVPYTETAVPDGEDADAFIQAGIKQDIEAPKPYGSSFVAFNLFTHTNGASTLVFRISHAQYDEICLPILFEQLSALYAGTTVPETVPFSKHINHVVLDNIPKAIPYWKNLLSGSEMTVLKPSIPLTHRGPADIYKEFDISRRPANITIGSLPTAAWALVLSRRLSRTDVVFGEVVSGRNVGAPNADRIFGPTWQYIPFRVAFSKSWSYLDLLRYVQDQHMTSAAYESMGFSEIVKNCTHWDPESVQWFDTVVHQAPAWVEEMPFGNGVEAKFQTLYPHAEPLREWKCQAFVKDGGRKLGIEIVTFEEWIGEAEGVLEEVGKALECLMEGRAGESIF

Gene
NPS6
Protein
Nonribosomal peptide synthetase 6
Organism
Cochliobolus miyabeanus
Length
1761 amino acids
Function
NRPS involved in extracellular coprogen-type siderophores biosynthesis including coprogen, neocoprogen I and neocoprogen II (PubMed:17056706). The role of extracellular siderophores in fungal virulence to plants is to supply iron to the fungus during plant infection, but not to act as phytotoxins, depriving their hosts of iron (PubMed:17056706).
Similarity
Belongs to the NRP synthase family.
Mass
194.707 kDa
Sequence
MSRHQAVLQLHFFASILETLLKDVNHPLSHFDKVSEDELDELWSWNTPLQPELRFCMHEKVSERAALHPEKIAIDAWDGTLTYGQIEDYSDKLAKLLRLLDDSSNRIIPVLFEKSRWTSVAVLAIMKSGACFALLDPAQPEGRLRAVVQQVNAKIFLSSKAQSTLAARVAPAATIIPISKSKFNKIFSPYTAEQPNTTLPPVSPDQPLYIQFTSGSTGVPKGCILTHSQYTSGAIPRAAAVGYYPHSRVLDFASYAFDVCIDSMLCTLAHGATLCTPSDERRMNDMSGAMRDMRVTFAGMTPSVARTLDVDILNNLESIALGGEGVSISDAMSWGQRTRVVNAYGPSEATVGATINDNVAAKPYITMGQRKGCALWLTEPEDHNKLVPVGAVGELLIEGPIVGNGYLNNPSKTKEVFIEDPEFLIKGSKSYPGRHGRIYKTGDLVRFDPDGDGEPIFVGRQDQQVKLRGQRIELAEIEFNMQKHLPPDTQLAAEVIKPSGGGEQTLVAFLVEQKKNGMRHLDGNVFGSFTNKFQSALRDMTKQLFVDLPSYMVPSAYIPLWKMPLLVSCKTDRKRLREIGASVTRQDLRRFNSAVSEKKEATTEMELKLQSLWAKVLGGDADFSANDNFFSMGGDSLRAMRLVAAARDEAIVLSVPDIMLNPTLSAMAEKAKPVSAEETNEVPPFSMIGKDWDADAARRESARLCGVDAANVEDVYPCTPLQEGLIALSAKFQDAYVAQRVATLPAKTALRLKEAFDTAVEGSPVLRTRIVNVTGRGLFQVVLKDGQLVREHGTDTSEYLRRDRNEPMDLGTALFRYGLVKEPESDQMNFVITMHHAVYDGWSMPLVFDHVNSAFNGLHTERPTSFKHFIKHLTSLDPADAQQYWKKRLEGTSPHQFPPLPQKGYTTQADSLLEHYVTVPTSAHSKLTLATIIRGAWALVSSLYIGHPDIVFGETLTGRSAPVPGIEQIEGPMITTVPIRVRLSLDRPITEYLQMIHAVTVKQIPHEHLGLQNIRRLSKDARVACDLRTGLVLHPKEDEDWGKVSLETPANTFLPASDEEGAREALKFNTYALMLVCTLEENGFLVMASFDSNCISKEAMERVLVVLDRIVHAFLGNPESKLGDVAVLDPAEARDAEAMRPRDVMSDSALGMSPVDGLESMDASLKELSPNEEKLRNILGRILGMKETDIRPSDSFFDLGGDSIGAMRLVSDARAQGLNLTVAQVFQSRSLSDLAASASNEREDKLAEILSRILGIAKSDIKSSDSFFELGGDSIGAMRLVSDARAQGLSITVAQVFQSKSLAELASSAEEEMPSQPKTNVDAPFIALGKDANLHSPDRVGVYLENQEWEITNIYPTRPLQQLAVEGTVDLPRYSLRYELIKFATPIDRQKLEQACQELVARNEVLRTVFVKDNELTLGVVLSALRVPYTETAVPEGEDADAFIQAGIKQDIEAPKPYGSSFVAFNLFTHPNGASTLVFRISHAQYDEICLPILFEQLSALYSGTTVPETVPFSKHVNHVVLDNIPKAIPYWENLLSGSEMTVLKPTIPLTHRGPADIYREFDISSRPANITIGSLPTAAWALVLSRRLNLTDVVFGEVVSGRNVGAPNADRIFGPTWQYIPFRVPFSKSWSYLDLLRYVQDQHMTSAAYESMGFSEIVKNCTNWDEDKVQWFDTVVHQAPAWVEELPFGNGVEAKFQTLYPHGEPLREWKCQAFVKEGGRKLGIEIVTFEEWIGEAEGVLEEVGKALECLMEGRVGESIF

Gene
NPS6
Protein
Nonribosomal peptide synthetase 6
Organism
Alternaria brassicicola
Length
1460 amino acids
Function
NRPS involved in extracellular coprogen-type siderophores biosynthesis (PubMed:17056706). The role of extracellular siderophores in fungal virulence to plants is to supply iron to the fungus during plant infection, but not to act as phytotoxins, depriving their hosts of iron (PubMed:17056706).
Similarity
Belongs to the NRP synthase family.
Mass
160.19 kDa
Fragment
single
Sequence
MSHHQAVSQLHLFVSILDALFSDPDCLLSSFMNVTEDELDELWSWNSPLQPELRFCMHEKVSEQAALHPEKIAIDAWDGTLTYRQVEDYSTDLAQTLQLLDGSHNQIIPVLFEKSRWTSVAVLAIMKAGACFALLDPAQPEGRLRAVVQQVSARLFVSSKAQATLAARVAPAATIIPVSASKFDKVYSPCAAQQPKTTLPPVSPDQPLYIQFTSGSTGLPKGCILTHSQYTSGAIPRADAVGYRSHSRVLDFASYAFDVCIDSMLCTLAHGATLCTPSDERRMNDMSGAMRDMRVTFAGMTPSVARTLDVDILDHLDSIALGGEGVSTSDAMSWGQRTRVVNAYGPSEATVGATINDNVASKPYITMGKRKGCAIWLTDPEDSNKLVPPGAVGELLIEGPIVATDISITRRKPRKFSLKIPNSWLKGSKSFPGRHGRIYKTGDLVRFDPDGNGEPIFVGRQDQQVKLRGQRIKLAEIEFNMQKHLPADTQLAVEVIKPSGGGEQTLVAFLVEQKKNGMRHLDGNVFGSFTTKFQSALKDMTKQLAVDLPGYMVPSAYIPLWKMPLLVSCKTDRKRLREIGTSVTRQDLRRFNSVISEKKEPTTEMEIKLRSLWGKLLGGEDDFSANDNFFSMGGDSLRAMRLVAAAREAGLVLNVPDIMLNPTLSAMATKIKPLSEEATNDVPAFSLIEKDWDMNSAKAETAKLCGVDVNEVQDVYPCTPLQEGLMALSAKFQDAYVAQRIATLPSETAQRLKEAFDTAAEGSPILRTRIVNVSGRGLFQVVLKNGRLLREHGADPAEYLRRDREEAMDLGTALFRYGLVQEAGSDETHFVITMHHAVYDGWSMPLIFDRINRAFNGLQTERSVSFKHFIKHLTSLDPAEAQDYWRERLAGVNPYQFPPLPQKGYTTQADSLLEHYVSVPTTAHNKLTLATIIRGAWALVSSLYMGHPDVVFGETLTGRSAPVNGIEEIEGPMITTVPIRVRLSLDRPISDYLQAVHAQTVKQIPHEHLGLQNIRRLSKDARVACDLRTGLVLHPREDDVGEVDMEAVPANTFLPADDAEAAREALKFNTYALMLVCTLDENGFLIMASFDSKCISKDAMERVLVVMNRIVTAFLGNPESKLGDVAVLDPSEAQDAEAMRPRDVMSDSGIGTSPIDSPKLDAAMKALSPNEEKLHSILGRILGMPETEIKSSDSFFELGGDSIGAMRLVSDARAQGLTLTVAQVFQSQSLAELAASIGNEKEDKLLDILSRILGMPKSEINGSDSFFELGGDSIGAMRLVSDARAQGLNLTVAQVFQSQSLSELASSAEETDSPQTETNSNAPYAALGKEASLYSPDRIGAYLQDQSWEIVDVYPTRPLQQLAVEGTVDLPRYSLRYELIKFATPINRQKLEQACQELVARNEVLRTVFVKDESKVLGVVLSSPRVPYSEIAVPDGEDINAFSQANIQKDIEAPKPHGSS