Function
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:15755917, PubMed:17056706, PubMed:23980626). Cochliobolus heterostrophus produces extracellular coprogen-type siderophores including coprogen, neocoprogen I and neocoprogen II, as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17601875). SIDA2 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:23980626). The assembly of extracellular coprogen-type siderophores is then performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17601875).
Sequence
MARHQAVSQLHFFALILESLFKGADHPLSHFHNVSEDELDELWSWNTPLQPELRFCMHEKVSERAALHPEKIAIDAWDGTLTYGQIEDYSDKLAKLLRLLDDSSNRIIPVLFEKSRWTSVAVLAIMKSGACFALLDPAQPEGRLRAVVQQVNAKIFLSSKAQSTLAARVAPAATIIPISKSKFNKIFSPYTAEQPNTTLPPVSPDQPLYIQFTSGSTGVPKGCILTHSQYTSGAIPRAAAVGYYPHSRVLDFASYAFDVCIDSMLCTLAHGATLCTPSDERRMNDMSGAMRDMQVTFAGMTPSVARTLEVDILNNLESIALGGEGVSISDAMSWGQRTRVVNAYGPSEATVGATINDNVAAKPYITMGKRKGCALWLSDPENHNKLVPVGAVGELLIEGPIVGNGYLNNPSKTKEVFIEDPEFLLKGSKSYPGRHGRIYKTGDLVRFDPDGDGEPIFVGRQDQQVKLRGQRIELAEIEFNMQKHLPPDTQLAAEVIKPSGGGEQTLVAFLVEQKKNGMRHLDGNVFGSFTNKFQDALRDMTKQLFVDLPSYMIPSAYIPLWKMPLLVSCKTDRKRLREIGASVTRQDLRRFNSAVSEKKEATTEMELKLQSLWAKLLGGDADFSANDNFFSMGGDSLRAMRLVAAARDEGVVLSVPDIMLNPTLSSMAEKAKPVSAEETSDVPPFSMIAKDWDVDAARQESARLCGVDVANVEDVYPCTPLQEGLIALSAKFQDAYVAQRVATLPAETAVRLKEAFDTAVQGSPILRTRIINVSGRGLFQVVLKDGQLVREYSTEVSEYLRLDRNEPMDLGTALFRYGLVEEPGSDKMNFVITMHHAVYDGWSMPLVFDRVNRAFNGLHTERPSSFKHFIKHLISLDPADAQQYWKERLEGTIPHQFPPLPQKGYTTQADSLLEHYVTVPTSAHSKLTLATIIRGAWALVSSLYMGHPDIVFGETLTGRSAPVPGIEQIEGPMITTVPIRVRLSLDRPIAEYLQKIHAQTVKQIPHEHLGLQNIRRLSKDARVACDLRTGLVLHPKEDEDWGTVDIRNPANTFLPANDAEGAREALKFNTYALMLVCTLEENGFLVMASFDSNCISKEAMERVLAVLDRIVHAFLGNPESKLGDVAVLDPVEAQDAEAMRPRDVMSDSALGMSPVDGPESMDASLKELSPNEEKLRSILGRILGMKETDIRPSDSFFDLGGDSIGAMRLVSDARAQGLNLTVAQVFQSSSLSDLAASASNEREDKLAEILSRILGMAKTDIKSSDSFFELGGDSIGAMRLVSDARAQGLNITVAQVFQSKSLAELASSAEEETPSQPRVDTDAPFIALGKDANLHSPDRVGLYLENQGWEITNIYPTRPLQQLAVEGTVDLPRYSLRYELIKFATPIDRQRLEQACQELVARNEVLRTVFVKDDGLTLGVVLSSLVVPYTETAVPDGEDADAFIQAGIKQDIEAPKPYGSSFVAFNLFTHTNGASTLVFRISHAQYDEICLPILFEQLSALYAGTTVPETVPFSKHINHVVLDNIPKAIPYWKNLLSGSEMTVLKPSIPLTHRGPADIYKEFDISRRPANITIGSLPTAAWALVLSRRLSRTDVVFGEVVSGRNVGAPNADRIFGPTWQYIPFRVAFSKSWSYLDLLRYVQDQHMTSAAYESMGFSEIVKNCTHWDPESVQWFDTVVHQAPAWVEEMPFGNGVEAKFQTLYPHAEPLREWKCQAFVKDGGRKLGIEIVTFEEWIGEAEGVLEEVGKALECLMEGRAGESIF