About Products Protein Database Contact

NPC2

Gene
NPC2
Protein
Non-specific phospholipase C2
Organism
Arabidopsis thaliana
Length
514 amino acids
Similarity
Belongs to the bacterial phospholipase C family.
Mass
57.681 kDa
Sequence
MSIKAFALIQLLSVTILYNHVHATSPIKTIVVVVMENRSFDHMLGWMKKLNPEINGVDGSESNPVSVSDPSSRKIKFGSGSHYVDPDPGHSFQAIREQVFGSNDTSMDPPPMNGFVQQAYSEDPSGNMSASVMNGFEPDKVPVYKSLVSEFAVFDRWFASVPSSTQPNRMFVHSGTSAGATSNNPISLAKGYPQRTIFDNLDDEEFSFGIYYQNIPAVLFYQSLRKLKYVFKFHSYGNSFKDHAKQGKLPAYTVIEQRYMDTLLEPASDDHPSHDVYQGQKFIKEVYETLRASPQWNETLLIITYDEHGGYFDHVPTPVRNVPSPDGIVGPDPFLFQFNRLGIRVPTIAVSPWIEKGTVVHGPNGSPFPSSEYEHSSIPATVKKLFNLSSPFLTKRDEWAGTFENILQIRKEPRTDCPETLPEPVKIRMGEANEKALLTEFQQELVQLAAVLKGDNMLTTFPKEISKGMTVIEGKRYMEDAMKRFLEAGRMALSMGANKEELVHMKTSLTGRRP

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
213 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
24.053 kDa
Sequence
MRVSVWYGLLHAAAWTRAVSLQVSEDSDEQWTVALRDSRPIPGGSPLSRCDLDEDHLLDVQEIEITPNPPHRGKNLTVEARGDLFGPVEDGAYVTVEVRLGYIKLLSETFDLCKELEENDLGLQCPLEEGEYELSKTVEIPQQVPPGRYHVVARAYTVDDEPITCLTGDVYFPPLMPAERSRMPRLIDPRRMRRLMDPRRKPRIMDEGSGAAA

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
196 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
21.449 kDa
Sequence
MVAYKNIALLALTFTIASVESLSIVGARPYIDKALSVFDIKTPNSQSEKPEIILTFAGPDDKPVPGDSPIVQCEASVPQLLNLQSVVIDPNPPLRGENLTFVAKGVLSQDIEDGAYVEVDVRYGFIKLLHQTFDLCEEITKIDLECPISKGQQVIEKKVEIPAEVPPGKYIVSARAYTKDDIFITCLSAMVEFPPL

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
193 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
20.795 kDa
Sequence
MHSRFIAVTLASLSLASQAVAWGCIGQDCNQAADQIAFSAPEPASYEGKVKSLAWEPTPGQGWQWSSCGTGDEVVNVESIVVSPDPPVPGQNLTVRAKGTVKDEVSDGTFADVIVKLGLIRLLARRFDVCEQARESNADLQCPLSAGEYELEHTVALPREIPPGKFNVHITGENQDGSNLLCLDLSIQFGFRR

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
192 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
21.197 kDa
Sequence
MVSFKNLAIVTLAVTTTSVEGISFSNIYLNKAITIFKNPTSLIPSFSNSKLINYQNTKPIPGDSPIEVCDASEKQLLHLDEVIVTPNPPVAGQNLTFTAVGTLDKTIEEGAYVEVEVRYGFIKLIHQTYDLCEEIVKVDLQCPIKSGKQTITKNVEIPEEVPPGKYLVVARAYTKDDEYITCLTATIIFPVQ

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
189 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
20.573 kDa
Sequence
MKLSILPLIALATAVVASPAPDANSMKLMNQAKDFGMSVAQGGLKDIAKTLDDEDIPGDSPISLCDAEYEQLLEIKHLSIDPNPPAKGQNLTIEASGYLYEDVEEGAYIEVEVRYGYIRLISQTLDLCEQSEQVDWSCPIKAGDLKLNKQIELPNEIPPGKYVAVARAYTVDDDLITCLLTTVTFPASL

Gene
npc2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
188 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
20.531 kDa
Sequence
MRLTTFIYAITCLPIFISASSWFSSFSFGESKSTDLVSSTSEKIPGANPASYCADWDRGDDHVVVDYINLIPNPPAAGKNLTIETEINVGTTVLNGSYVDIQVKYGFVRIVNERLDICDKAYELAAVECPVEPGIITKQATISLPWAIPPGRYHVLATAYNADGEQLTCVSASVSFSHFGFQLINQDH

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
185 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
20.113 kDa
Sequence
MQVKSLISSVALWGCAFTVANPIIGWGIGDVDKKAPMPPGFGETKPIPGDSPLKMCDIAEGQLLEITKLDLVPNPPKRGSKLVIKASGEIFETIEEGAYVDVEVRLGYIKLLTQTYDLCEILEDNDVDGLTCPIKKGKYDNLSKDVDIPQEVPPGKYLVTARAYTNDDDLITCITGEVYFPPPGI

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
180 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
19.32 kDa
Sequence
MKLAPFLIPFIATTVTASLAGEALSWAGQLVGGGRGALATGDGPVRTENSWSYVDCGLATDAIQLKSIKVHPDPPVPGKNLTVTVEGDVLETIEEGAYVDVTVKLGLIKLLQKEFDVCDEARHANASVQCPVQPGPYTVTETVELPQEIPKAKFSVLVRGYTVDDEDMVCLDLFVDFMKK

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
180 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
19.32 kDa
Sequence
MKLAPFLIPFIATTVTASLAGEALSWAGQLVGGGRGALATGDGPVRTENSWSYVDCGLATDAIQLKSIKVHPDPPVPGKNLTVTVEGDVLETIEEGAYVDVTVKLGLIKLLQKEFDVCDEARHANASVQCPVQPGPYTVTETVELPQEIPKAKFSVLVRGYTVDDEDMVCLDLFVDFMKK

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
178 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
19.555 kDa
Sequence
MRFSTAFLALLSVGFSSARLQGRDQVPVALDDDHKIPGESPLKLCDGDHKDDILKITKVDLSPNPPKAGESLVIKASGDVTQKIEEGAYINLSVKYGLIRLINTKADLCEQIKNVDLECPIDEGKLDIVKSVDLPNEIPPGKYTVFADVYTKDNKKISCLTAEVRFERNSIATPWGDL

Gene
npc2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
175 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
19.083 kDa
Sequence
MKLISTAATLFVCLAPLSASARSISFFDSTQAPIQLETFPVKGDNPLVYCSDPSGNILQIESVDLVPNPPLPGQTLSINASGNLKERVEEGAYVALEVKYGLITLIKQTADLCEQIKNVDLECPLEKGEMTLTKQVDLPSHIPPGKYNVHADVYTKDGKKITCLDAHDIEFKIRP

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
173 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
18.816 kDa
Sequence
MRFSVVTSYLLCAAASYANAASLFGLSFPEPPSANKPIPGDSPLLQCDVDQSQSLDVTQVNLVPNPPQRGENLTIAAAGVLQTTIEEGAYIDIEVRLGYIKLISQTYDLCEQLEENDIDGLKCPIEEGVYELNKIVEIPSEVPPGKYSVIARAYNVDDEQITCLTGEVIFPAY

Gene
NPC2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
173 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
19.063 kDa
Sequence
MTHSLKALFALLFLYTAAVNAGVIGIFNALPPPNTKPINGESPLYQCDILDKQLVEIKEVNLDPNPPVRGENLTISANGEVFETIEEGAYIDVEVRLGYIRLLSQTFDLCETLEDNDIEGLSCPIEPGEYNIKKIVEIPGEVPPGKYVVVARAYTEKDDLITCLTGEVIFPPR

Gene
npc2
Protein
Phosphatidylglycerol/phosphatidylinositol transfer protein
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
169 amino acids
Function
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Similarity
Belongs to the NPC2 family.
Mass
18.297 kDa
Sequence
MKLLSPATALLFLAPLAVTATPASFFGYTQDVIAEGAPVRGDNPLEYCSEPSGDILEINSVDLAPNPPKAGTTLKIRAAGNLHERIEAGAYVVLEVKYGLITLLRDTADLCAQLTNVDLQCPLEEGPMVLTKEVDLPSQIPRGRYTVHADVYTKDNKRITCLDAKNIQF

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Macaca fascicularis
Length
151 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.57 kDa
Sequence
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Pan troglodytes
Length
151 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.57 kDa
Sequence
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Homo sapiens
Length
151 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.57 kDa
Sequence
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL

Gene
Npc2
Protein
NPC intracellular cholesterol transporter 2
Organism
Mus musculus
Length
149 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:12591949, PubMed:17018531, PubMed:21315718, PubMed:26296895). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (PubMed:21315718).
Similarity
Belongs to the NPC2 family.
Mass
16.442 kDa
Sequence
MRFLAATILLLALVAASQAEPLHFKDCGSKVGVIKEVNVSPCPTDPCQLHKGQSYSVNITFTSGTQSQNSTALVHGILEGIRVPFPIPEPDGCKSGINCPIQKDKVYSYLNKLPVKNEYPSIKLVVEWKLEDDKKNNLFCWEIPVQITS

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Sus scrofa
Length
149 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:10366780). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.288 kDa
Sequence
MHFLAAAFLLLTLSASALAEPVHFRDCGSGVGVIKEVNVNPCPTQPCQLHKGQSYSVNVTFTSNTQSKGSKAVVHGIVMGVPIPFPIPDPDGCKSGINCPIQKDQTYSYLNKLPVKAEYPSIKLVVEWKLQDDNDQCLFCWQIPVQIES

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Bos taurus
Length
149 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:29580834, PubMed:17552909). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17573352). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.64 kDa
Sequence
MRFLTVAFLFLALSASALAEPVKFKDCGSWVGVIKEVNVSPCPTQPCKLHRGQSYSVNVTFTSNTQSQSSKAVVHGIVMGIPVPFPIPESDGCKSGIRCPIEKDKTYNYVNKLPVKNEYPSIKVVVEWELTDDKNQRFFCWQIPIEVEA

Gene
NPC2
Protein
NPC intracellular cholesterol transporter 2
Organism
Canis lupus familiaris
Length
149 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Similarity
Belongs to the NPC2 family.
Mass
16.056 kDa
Sequence
MRLLVAAFLLLALGDLGPGGAVHFKDCGSAVGVIKELNVNPCPAQPCKLHKGQSYSVNVTFTSNIPSQSSKAVVHGIVLGVAVPFPIPEADGCKSGINCPIQKDKTYSYLNKLPVKNEYPSIKLVVQWMLLGDNNQHLFCWEIPVQIEG

Gene
npc2
Protein
NPC intracellular cholesterol transporter 2
Organism
Danio rerio
Length
149 amino acids
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol.
Similarity
Belongs to the NPC2 family.
Mass
16.306 kDa
Sequence
MDYRVLGVVLLSFLAYTCADPVKFVDCGSVDGKVVQVDIKPCSQQPCKLHKGQSYTVNVTFSSGVESQTSKAVVHGVLAGVPVPFPIPIDDGCKSGIQCPIVPQKPYNYVTELPVKTEYPAIKVVVEWELRDDSSKDLFCIKFPVQIVN