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NOP2

Gene
NOP2
Protein
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
Organism
Homo sapiens
Length
812 amino acids
Function
Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
89.302 kDa
Sequence
MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS

Gene
Nop2
Protein
Probable 28S rRNA (cytosine-C(5))-methyltransferase
Organism
Mus musculus
Length
793 amino acids
Function
Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
86.752 kDa
Sequence
MGRKLDPTKKEKRGPGRKARKQKGAETELVRFLPAAGDENSKRLSSRARKRAAKRRAGSVDVPKPNKSPGIKTLPGELSKGAVQARGKKRPAPIQNSDGDEEEDSGEDDVVTQGDLWGSEDSDEDMVDDYGAASNSEDEEEKLLPIERAALKQKAQDATAGVLWNEEDTDEDEDDDGVSPESHPRKDDKAEGDLQINVEDEEAFVLPPAGETDQDGQAPDLQRVHKRIQDIVGVLRDFGAQREEGRSRAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNTLKTRRRDLAQLLINRGVNLDPLGKWSKSGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAASKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFQARRFHPTLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQPHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEPSVPDAQVSTRPSQSAGNADVNSKRKRSEKLKQRGPKWKPSKEAAVPKPSAPSRVEDSGTPVPTPSEIRAAPRPKDCAPSLGKAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKRRKSMTKGNSQPLLS

Gene
NOP2
Protein
25S rRNA (cytosine(2870)-C(5))-methyltransferase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
618 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
69.812 kDa
Sequence
MGSRRHKNKQAAPPTLEEFQARKEKKANRKLEKGKRPSTTQGDEVSDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKARKSLFDDEEDDDEAGLVDEELKDEFDLEQEYDYDEDEDNDAHPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEEAEEAEMELVEAENMQPRADILPTEEQEEMMAQETPNLTSTRTRMIEIVKVLENFKTLGAEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLFSPAEAMEFFEANEIARPITIRTNTLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGATPEYLAGHYILQAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRTKSLIANIHRLGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAIGKEAFTSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIGPSSFDDNQASAKEKETAARKEALEEGIIHSDFATFEDEEDDKYIEKSVKNNLLKKGVNPKAKRPSNEK

Gene
nop2
Protein
25S rRNA (cytosine-C(5))-methyltransferase nop2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
608 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (By similarity).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Mass
68.935 kDa
Sequence
MGRKQKSKQGIPPTLEENHNSSHKVTENAKKRKHSKEKPQNSRKRQLAEEKKSLFENSDSENEKDLIDADEFEEAETLSDLEHDEEPQTFADEFIDDEAKECEGEEEDSVFDSDEEHEVKPMFSDDSGDEEDLELANMEAMSRKLDEEAELEEKEAEEELHTNIHPEAPTVLPPIDGFTDSQPISTLPQDLSQIQLRIQEIVRVLNDFKNLCEPGRNRSEYVDQLLNDICAYYGYSRFLAEKLFELFSVSEAVEFFEANEMPRPVTIRTNTLKTQRRELAQALINRGVNLEPIGKWSKVGLQVFESQVPIGATPEYLAGHYILQAASSFLPVMALAPQPNERILDMSSAPGGKVTYVAALQKNTGIIFANDSNKARTKALSANIHRLGVRNAIVCNYDGRKFPNEVIGGFDRVLLDAPCSGTGVIYKDQSVKTNKSERDFDTLSHLQRQLLLSAIDSVNADSKTGGFIVYSTCSITVDEDEAVIQYALKKRPNVKLVSTGLEFGREGFTRFREKRFHPSLKLTRRYYPHVHNIDGFFVAKLKKISDKIPTVNVADDMKDGTNNDVEIEKNSTEIDNITFNDEADKEIIEQNRRKWLKSKGYKVAKKKD