Protein
Nitrogen network kinase 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
Serine/threonine-protein kinase involved in the phosphorylation of the NAD(+)-dependent glutamate dehydrogenase GDH2. When overexpressed, confers hypersensitivity to rapamycin and induces rapid nuclear accumulation of GLN3 to activate the transcription of nitrogen-regulated genes.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Sequence
MFTSQRQLRQNGSPMSSSRSSQHSSGTASPISDSPASNRSYGRDLRGLMGIDIPANEPAFNRANSSDTIYFRPKKIYKMEHEHPSRSTLVQLQTRSQPDDVASSQVNPEGGTDDLELGDPCGNQSLYTIGAEYVPDLDFTKLVNEWQKSTEDLYEFRSSATPQVQIKDSGKGNYELWSSPDAILTQNKLRRDSFSQENSDSLSPEDSILSRNLHSKVKPIPLPRNSQQIFTPLSNLEAERRSSYTTSSNNNSITQNNKFSFAKLKYSLPTQSSAVPASFDSNASSLNFLPTTTLSTLSELQISPNDMMDLIQKLPRNFLNLPYTQRKKVIIEHAPSHDYKAMMSLVKKFMLTSSRSNFSLAGFANNASVSQATANDDNINSRNTPNNSNDTYVNTRPLQRSRHGSIASQFLSSFSPSMTSIAKMNSNPLSGSAGGSARPDDKGMEILGHRLGKIIGFGAWGIIRECFDIETGVGRVIKIVKFKGHQNIKKHVLREVAIWRTLKHNRILPLLDWKLDDNYAMYCLTERINDGTLYDLVISWDEFKRSKIPFAERCRLTIFLSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHFDEKHVYRNDTFDENLSSGNSHRKRKSIEQTNLIKYPTTNFLPDDRTNDFDASENLKYQFENRKHQPFTPKGMVSSSSHSLKHLNQPSSSSSSNLFHKPASQPQPQHRSPFHGRHKTTDFSNLEPEPSKYIGSLPYASPELLRYSDARRSKSVEMHIYDSPDSSQSEISAASSSSSNLSSLSSSTKASAVTNSGVTTSSPSGSSTDFPCIVSPLGPASDIWALGVMLYTMLVGKLPFNHEFEPRLRSLIKVGEFDRFSLAQVCKFDRKKNEGTIGQGLYDTVIGCLTIDLDKRWKLKRIEEVLQNEMNLSEAIHDNNGS