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NKX3-2

Gene
NKX3-2
Protein
Homeobox protein Nkx-3.2
Organism
Homo sapiens
Length
333 amino acids
Function
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).
Similarity
Belongs to the NK-3 homeobox family.
Mass
34.814 kDa
Sequence
MAVRGANTLTSFSIQAILNKKEERGGLAAPEGRPAPGGTAASVAAAPAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAGRTAESPEGWDSDSALSEENESRRRCADARGASGAGLAGGSLSLGQPVCELAASKDLEEEAAGRSDSEMSASVSGDRSPRTEDDGVGPRGAHVSALCSGAGGGGGSGPAGVAEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ

Gene
Nkx3-2
Protein
Homeobox protein Nkx-3.2
Organism
Mus musculus
Length
333 amino acids
Function
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
Similarity
Belongs to the NK-3 homeobox family.
Mass
35.167 kDa
Sequence
MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRARVTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGAAGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ

Gene
nkx3-2
Protein
Homeobox protein Nkx-3.2
Organism
Xenopus laevis
Length
329 amino acids
Similarity
Belongs to the NK-3 homeobox family.
Mass
36 kDa
Sequence
MFRGPLDTPWAADVSPSGPRGIKAGRSALLVPILGSIWGAWRPEPGATRYRTLDPMAAVRSSSRLTPFSIQAILNRKEERAHTFPRLATAVSPACCWRIFGESEAEGLGSPCGGAPGAGAGGEPSGWDSDSALSEEGELGRPGDIGERKKQRPLEARAKGEDEEETPGCSDCEIGASVPDPSPPDEDPKCEQLMLEPPKQRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMATDLLAAAPAAKKVAVKVLVRDDQRQYHPGEVLHPSLLPLQAPYFYPYYCALPGWTLSAAACSRGTP