Protein
Probable dehydratase NIT22
Organism
Ajellomyces capsulatus
Function
Probable dehydratase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence via intracellular iron acquisition during macrophage infection (PubMed:18404210).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MACPCGARVLVEILTGLLSLKNQSPSTPPESEGEFTRNYILGPKYIIKAIEIFSTMPNTIPPFEYAPVKTTWLKRDVLLFAHSIGCKAGDELHFLYELHPKFQVFPTYPIVLTFKHADIDIVDFLARNAARTLPPGCPVLDWSVAVDGRRRMEFLCPLPPSSEGKTWDIHTKVLGVFDKGAGKGTVMEMEHVLKQRESGQVYTRAWESVFFKGTGGWGGERGPKMNEHVPSTPPRRPDAVSSFQSNAESAHLYRLNGDYNPLHATPEPGKSLGYGGTIMHGLFSWNITARAVLSQFGGSEGRRLRDFEAMFSSPVKPGDKLDILMWDMGLCKRATSAVRNDESLQEVRFMVKVGDRVVLSNGKALLKCEDEGVEVKL