NIT22

Gene

NIT22

Protein

Probable dehydratase NIT22

Organism

Ajellomyces capsulatus

Length

377 amino acids

Function

Probable dehydratase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence via intracellular iron acquisition during macrophage infection (PubMed:18404210).

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Mass

41.885 kDa

Sequence

MACPCGARVLVEILTGLLSLKNQSPSTPPESEGEFTRNYILGPKYIIKAIEIFSTMPNTIPPFEYAPVKTTWLKRDVLLFAHSIGCKAGDELHFLYELHPKFQVFPTYPIVLTFKHADIDIVDFLARNAARTLPPGCPVLDWSVAVDGRRRMEFLCPLPPSSEGKTWDIHTKVLGVFDKGAGKGTVMEMEHVLKQRESGQVYTRAWESVFFKGTGGWGGERGPKMNEHVPSTPPRRPDAVSSFQSNAESAHLYRLNGDYNPLHATPEPGKSLGYGGTIMHGLFSWNITARAVLSQFGGSEGRRLRDFEAMFSSPVKPGDKLDILMWDMGLCKRATSAVRNDESLQEVRFMVKVGDRVVLSNGKALLKCEDEGVEVKL

Protein

Probable dehydratase NIT22: NIT22