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NIT2

Gene
NIT2
Protein
Nitrilase 2
Organism
Arabidopsis thaliana
Length
339 amino acids
Function
Can convert indole-3-acetonitrile to the plant hormone indole-3-acetic acid.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Mass
37.153 kDa
Sequence
MSTSENTPFNGVASSTIVRATIVQASTVYNDTPATLEKANKFIVEAASKGSELVVFPEAFIGGYPRGFRFGLGVGVHNEEGRDEFRKYHASAIKVPGPEVEKLAELAGKNNVYLVMGAIEKDGYTLYCTALFFSPQGQFLGKHRKLMPTSLERCIWGQGDGSTIPVYDTPIGKLGAAICWENRMPLYRTALYAKGIELYCAPTADGSKEWQSSMLHIAIEGGCFVLSACQFCLRKDFPDHPDYLFTDWYDDKEPDSIVSQGGSVIISPLGQVLAGPNFESEGLITADLDLGDVARAKLYFDSVGHYSRPDVLHLTVNEHPKKPVTFISKVEKAEDDSNK
Protein
Nitrilase 2: NIT2

Gene
nit2
Protein
Nitrilase homolog 2
Organism
Dictyostelium discoideum
Length
328 amino acids
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
36.945 kDa
Sequence
MYRGLINSFKNTSKFSTSLFNNNNNCSTTTKSFTHISQQLRKVHLMADKEKVFKFAGIQLLCGDNKEENVQNAIKHIDEAAKNGAKLISLPECFNSPYSTSTFEKYSETEDGETVKKLSEAAKRNQIFLVGGSIPEIDKATGKIYNTCFIFNDKGEVVKKHRKIHLFDIDVPNKIRFKESETLTPGDSFSVVDIGYCKIGVAICYDIRFPELAMLYSKMGAKFLIYPGAFNMVTGPAHWELLQRGRAVDNQVFVAAISPARNPSSTYQAWGHSTIVNSWGTILATTDEHQSIIYSDIDLNTLNETRSSIPIYSQKRDDLYKLDSIKKQ
Protein
Nitrilase homolog 2: nit2

Gene
NIT2
Protein
Deaminated glutathione amidase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
307 amino acids
Function
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
34.693 kDa
Sequence
MTSKLKRVAVAQLCSSADLTKNLKVVKELISEAIQKKADVVFLPEASDYLSQNPLHSRYLAQKSPKFIRQLQSSITDLVRDNSRNIDVSIGVHLPPSEQDLLEGNDRVRNVLLYIDHEGKILQEYQKLHLFDVDVPNGPILKESKSVQPGKAIPDIIESPLGKLGSAICYDIRFPEFSLKLRSMGAEILCFPSAFTIKTGEAHWELLGRARAVDTQCYVLMPGQVGMHDLSDPEWEKQSHMSALEKSSRRESWGHSMVIDPWGKIIAHADPSTVGPQLILADLDRELLQEIRNKMPLWNQRRDDLFH
Protein
Deaminated glutathione amidase: NIT2

Gene
nit2
Protein
Omega-amidase NIT2
Organism
Danio rerio
Length
277 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.366 kDa
Sequence
MSKFRLAVVQLHVSKIKADNLGRAQTLVKEAAGQGAKVVVLPECFNSPYGTGFFKEYAEKIPGESTQVLSETAKKCGIYLVGGSIPEEDGGKLYNTCSVFGPDGTLLVTHRKIHLFDIDVPGKIRFQESETLSPGKSLSMFETPYCKVGVGICYDIRFAELAQIYAKKGCQLLVYPGAFNMTTGPAHWELLQRGRAVDNQVYVATASPARDETASYVAWGHSSVINPWGEVISKAGSEESVVYADIDLQYLADVRQQIPITKQRRNDLYSVNSVQEG
Protein
Omega-amidase NIT2: nit2

Gene
NIT2
Protein
Omega-amidase NIT2
Organism
Bos taurus
Length
276 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.518 kDa
Sequence
MATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSLFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYEVEAKKS
Protein
Omega-amidase NIT2: NIT2

Gene
NIT2
Protein
Omega-amidase NIT2
Organism
Homo sapiens
Length
276 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.608 kDa
Sequence
MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP
Protein
Omega-amidase NIT2: NIT2

Gene
Nit2
Protein
Omega-amidase NIT2
Organism
Mus musculus
Length
276 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.502 kDa
Sequence
MSTFRLALIQLQVSSIKSDNLTRACSLVREAAKQGANIVSLPECFNSPYGTTYFPDYAEKIPGESTQKLSEVAKESSIYLIGGSIPEEDAGKLYNTCSVFGPDGSLLVKHRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCKVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRARAVDNQVYVATASPARDDKASYVAWGHSTVVDPWGQVLTKAGTEETILYSDIDLKKLAEIRQQIPILKQKRADLYTVESKKP
Protein
Omega-amidase NIT2: Nit2

Gene
Nit2
Protein
Omega-amidase NIT2
Organism
Rattus norvegicus
Length
276 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.701 kDa
Sequence
MSTFRLALIQLQVSSIKSDNITRACSLVREAAKQGANIVSLPECFNSPYGTNYFPEYAEKIPGESTKKLSEVAKENSIYLIGGSIPEEDDGKLYNTCAVFGPDGNLLVKHRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYARRGCQLLVYPGAFNMTTGPAHWELLQRARAVDNQVYVATASPARDEKASYVAWGHSTVVDPWGQVLTKAGTEETILYSDIDLKKLSEIRQQIPILKQKRADLYSVESKKP
Protein
Omega-amidase NIT2: Nit2

Gene
nit2
Protein
Probable hydrolase nit2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
276 amino acids
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.421 kDa
Sequence
MTLAAVAQLNSSGSILKNLAICKELISQAAAKGAKCIFFPEASDFIAHNSDEAIELTNHPDCSKFIRDVRESATKHSIFVNICVHEPSKVKNKLLNSSLFIEPLHGEIISRYSKAHLFDVEIKNGPTLKESNTTLRGEAILPPCKTPLGKVGSAICFDIRFPEQAIKLRNMGAHIITYPSAFTEKTGAAHWEVLLRARALDSQCYVIAPAQGGKHNEKRASYGHSMIVDPWGTVIAQYSDISSPNGLIFADLDLNLVDHVRTYIPLLRRNDLYPTI
Protein
Probable hydrolase nit2: nit2

Gene
nit2
Protein
Omega-amidase NIT2
Organism
Xenopus tropicalis
Length
276 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.805 kDa
Sequence
MAKFRLSLVQFLVSPVKSENLNRACKLIKEAAQKGAQIVALPECFNSPYGTKYFPEYAEKIPGESTERLSQVAKECGIYLIGGSIPEEDSGKLYNTCAVFGPDGTLLVKHRKIHLFDIDVPGKIRFQESETLSPGDSFSVFETPYCKVGVGICYDIRFAELAQLYSKKGCQLLVYPGAFNMTTGPAHWELLQRARALDNQVYVATASPARDEKASYVAWGHSTIVSPWGEVIAKAGSEETVISADIDLEYLAEIREQIPIRRQRRHDLYSVEEKKN
Protein
Omega-amidase NIT2: nit2

Gene
NIT2
Protein
Omega-amidase NIT2
Organism
Pongo abelii
Length
275 amino acids
Function
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.
Similarity
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Mass
30.483 kDa
Sequence
MASFRLALIQLQISSINSDNVTRACSFIREAATQGAKIVSLPECFNSPYGTKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFCTFDTYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP
Protein
Omega-amidase NIT2: NIT2