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NHP2

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Organism
Drosophila melanogaster
Length
160 amino acids
Function
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.724 kDa
Sequence
MGKVKVERSEDADESVVASGDVTIKEEESYDDKLIFVNAIAKPMAGKKLAKKCYKLVKKAMKHKTFLRNGLKDVQTRLRKGETGICIFAGDVTPVDIMCHLPAVCEEKGIPYTYTPSRADLGAAMGVKRGTVALLVRQNEEYKDLYDEVKEELSALNIPV

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Organism
Drosophila yakuba
Length
160 amino acids
Function
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.722 kDa
Sequence
MVKVKVERSEDADESVVASGDVTIKEEESYDDKLIFVNAIAKPMAGKKLAKKCYKLVKKAMKHKTFLRNGLKDVQTRLRKGETGICIFAGDVTPVDIMCHLPAVCEEKGIPYAYTPSRADLGAAMGVKRGTVALLVRQNDEYKDLYDEVKEELSALNIPV

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit NHP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
156 amino acids
Function
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512, PubMed:9848653). Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (PubMed:9843512, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512). Directly binds H/ACA snoRNAs (PubMed:11433018).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.122 kDa
Sequence
MGKDNKEHKESKESKTVDNYEARMPAVLPFAKPLASKKLNKKVLKTVKKASKAKNVKRGVKEVVKALRKGEKGLVVIAGDISPADVISHIPVLCEDHSVPYIFIPSKQDLGAAGATKRPTSVVFIVPGSNKKKDGKNKEEEYKESFNEVVKEVQAL

Gene
nhp2
Protein
H/ACA ribonucleoprotein complex subunit nhp2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
154 amino acids
Function
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:10502409). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (By similarity). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (By similarity). Directly binds H/ACA snoRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.178 kDa
Sequence
MAKDKKDHKHSGSTEDEYDSYLPALMPIAKPLAPKKLNKKMMKTVKKASKQKHILRGVKEVVKAVRKGEKGLVILAGDISPMDVISHIPVLCEDNNVPYLYTVSKELLGEASNTKRPTSCVMIVPGGKKKDMSKVEEYKESYEEIIKEVPALEV

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit 2
Organism
Bos taurus
Length
153 amino acids
Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.197 kDa
Sequence
MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQALPPPM

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit 2
Organism
Homo sapiens
Length
153 amino acids
Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.201 kDa
Sequence
MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL

Gene
Nhp2
Protein
H/ACA ribonucleoprotein complex subunit 2
Organism
Mus musculus
Length
153 amino acids
Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.247 kDa
Sequence
MTKVKAAPEESEAQAEGCSEERTYKELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVLCEDQNLPYVYIPSKTDLGAATGSKRPTCVIMVKPHEEYQETYDKCLEEVQALPTPL

Gene
NHP2
Protein
H/ACA ribonucleoprotein complex subunit 2
Organism
Pongo abelii
Length
153 amino acids
Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
17.187 kDa
Sequence
MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHDEYQEAYDECLEEVQSLPLPL

Gene
nhp2
Protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Organism
Danio rerio
Length
150 amino acids
Function
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
16.688 kDa
Sequence
MTKVKKEKAGEEETGGTEKSYQELIANINPIANPLASRKLSKKLYKCVKKAAKVKQIRRGVKEVQKFINKGETGIVVFAGDTLPIDVYCHLPIMCEDRSLPYAYVPSKVDLGSSAGSKRPTCVIMIKPHDEYKEAYDECVEEVTSLPKPI

Gene
nhp2
Protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Organism
Xenopus laevis
Length
149 amino acids
Function
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
16.775 kDa
Sequence
MTKVKKEECEEVPETPSKSYDELLSYLNPVAKPLAGRKLTKKLYKCVKKAIKQKNIRRGVKEVQKFINKGEKGIVVMAGDTLPIEVYCHIPVMCEDRGIPYSYVPSKSDLGAAAGSKRPTCVILIKPHEDYQEAYDECLEDVQALPLPY

Gene
nhp2
Protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Organism
Xenopus tropicalis
Length
149 amino acids
Function
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs (By similarity).
Similarity
Belongs to the eukaryotic ribosomal protein eL8 family.
Mass
16.729 kDa
Sequence
MTKAKKEESEEVPETPSKSYDELLAYLNPIAKPLAGRKLTKKLYKCVKKAIKQKNIRRGVKEVQKFINKGEKGIVVMAGDTLPIEVYCHIPVMCEDRGIPYSYVPSKSDLGAAAGSKRPTCVILIKPHEDYQEAYDECLEDVQALPLPY