Protein
Hydroxysqualene synthase
Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Function
Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP). Catalyzes the second step, the conversion of presqualene diphosphate (PSPP) to hydroxysqualene (HSQ).
Similarity
Belongs to the phytoene/squalene synthase family. HpnC subfamily.
Sequence
MTSGSGPRSDAMHREKNFPVASWIIHPRHRALILAFYRFVRMADDIADHATLAPDEKLLYLDLLEAELLGKGETRAEAVHLRTALDRRGMPPRHALDLLTAFRMDVTKQRYENWDEVIDYCRYSAMPVGRFVLDVHGESAATWPASDVLCAGLQVCNHLQDCGKDFLNLNRVYIPRDALSASGASIEELGAAKSSLQMLQCLRSLAAKAEVLLNGGGALVSQVKDFRLRFEVSVILSFADKIVSMLKMRDPLRERVHLSPLELLLHGVGAMANEAARRAFGRGTRFKTTVDV