NFIL3

Nuclear factor interleukin-3-regulated protein

462 amino acids

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).

Belongs to the bZIP family. NFIL3 subfamily.

51.436 kDa

MQLRKMQSIKKEQASLDAGTNVDKMMVLNSALTEVSEDLTTGEELLLNEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSTVSAFVDEHEPSMVASSCISVIKHSPQSSLSDVSEVSSLEHSQEGPVQNGCRSPESKFQVIKQEPMELESYAREPRDDRGAYRGAVYQNYMGNSFPGYSHSPPLLQVNRSSSNSPRTSETDEGAVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDHEFDGTQKLSSPVDMTSKRHFELEKHTTPNLVHSSLTPFSVQVTNIQDWSLKSEHWHQKELNGKTQSSFKTGVVEVKDSGYKVSDPENLFLKQGIANLSAEVVSLKRLIATHQISASDSG

nfil3

Nuclear factor interleukin-3-regulated protein

462 amino acids

May act as a transcriptional regulator of a number of proteins of the circadian clock.

Belongs to the bZIP family. NFIL3 subfamily.

51.501 kDa

MQAIKKEPPCSGPYGGEDALVLAVALQGTDRDLINHKLSTLPFKSKSTSCRRKREFIPDEKKDNLYWERRRKNNEAAKRSREKRRLNDMVLENKLMALGEENASLKAELLSLKLRFGLVSSAAYAQEVQNISTSTAALYQDFMSPSATKDSYPSDLEPTRLTSSCISVIKHSPHSALSDGSDSSTVTQGSPLINISRSPDSIKQEPLETGRYSKERISPYELYRNYLSSPFPGNFSQPSPFLQIARSSSNSPRTSDGDDGAVSKSSDNEDEQQVPKGPVPTRSDSQSVIVSTLKVPDSSASALPHKLRIKARAIQIKVEAIDPDYESSGKSSFPVDMSARRRYQMSQCATPEYIQSSLSPMSFQMTNVQDWNHRPKEWHEDHQEALTSYKYRQCPDSPRPVPNKLIVDLENDSYANSESENLYLKQGIEDLSAEVACLKRLISKQQGSVIESTKSTTEIDSS

NFIL3

Nuclear factor interleukin-3-regulated protein

462 amino acids

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).

Belongs to the bZIP family. NFIL3 subfamily.

51.472 kDa

MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRSPENKFQIIKQEPMELESYTREPRDDRGSYTASIYQNYMGNSFSGYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVELKHVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDNEFEATQKLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQDWSLKSEHWHQKELSGKTQNSFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRLIATQPISASDSG

Nfil3

Nuclear factor interleukin-3-regulated protein

462 amino acids

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5 (PubMed:30555544). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (PubMed:29653076).

Belongs to the bZIP family. NFIL3 subfamily.

50.943 kDa

MQLRKMQTIKKEPAPLDPTSSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKAAVSSFVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVIKQEPVELESFAREAREERGTYSTSIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADAIAKRHFDLEKHGTSGMAHSSLPPFSVQVTNIQDWSLKSEHWHHKELSSKTQSSFKTGVVEVKDGGYKVSEAENLYLKQGIANLSAEVVSLKRFIATQPISASDSR

Nfil3

Nuclear factor interleukin-3-regulated protein

462 amino acids

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).

Belongs to the bZIP family. NFIL3 subfamily.

50.781 kDa

MQLRKMQAIKKEPASLDPTGSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTVYAQEIQKLSNSTAVYFQDYQTSKAAVSSYVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVIKQEPVELESFARESREERGAYSASIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADALAKRHFDLEKHGASGTAHSSLPPFSVQVTNIQDWSLRSEHWHHKELGGKTQGTFKTGVVEVKDSGYKVSEAENLYLKQGVANLSAEVVSLKRFIATQPISASDSR

nfil3

Nuclear factor interleukin-3-regulated protein

462 amino acids

May act as a transcriptional regulator of a number of proteins of the circadian clock.

Belongs to the bZIP family. NFIL3 subfamily.

51.878 kDa

MQLRKMPTIKREQECADSRNNMENILVLSSNIPDMSESMDSSNDMLYSEGAPAKNKNSSCRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDMVLENKLIALGEENASLKTELLSLKLKFGLISSASYAQEIQKVTTSTAMYFQEYSSSKPNVMSYNSDHEHSVMTSSCISVIKHSPQSSLSDVSEASSVEHVQPSTVQSNCRSTDINFQRIKQEPMERENFSRDAREDSNTFQGSIYTNYIGNTFSGYSHSPPLLHINRSSSNSPRTSEADEGVVGKTSDGEDEQQVPKGPIHSPVELKNGHTTIIKVPEVNSSALPHKLRIKAKAMQIKVEALESELNSTQKLTLPIDMSSKRHLQLEKHNSETMVHSSLSPLSVQVTNIQDWPLKPGQWHHRELDKIPSVCKTSGIVDIKDNVFKASESESLYLKQGIANLSAEVATLKRLIVTQEICASNSS

NFIL3

Nuclear factor interleukin-3-regulated protein

458 amino acids

Acts as a transcriptional regulator (By similarity). Represses PER2 transcription through a recognition sequence in the promoter (PubMed:11427718, PubMed:15182670). Component of the circadian clock that may contribute to the rhythmic expression of PER2 gene in a light-dependent and time-of-day-dependent manner (PubMed:11427718, PubMed:15182670).

Belongs to the bZIP family. NFIL3 subfamily.

51.351 kDa

MQLRKMQTLKKEHGSVDTSSNVDKIMVLKSTLAEVSEELSTNEDILLTEASSGKSKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSASYAQEIQKLSSSTTVYFQDYQSSKPNINSFVDEHEPSVVGSSCISVIKHSPQSSMSDMSEMPSVEHTQGSRIQSNCRSPENKFQIIKQEPIELEREPRDDRGSYKASIYPNYMGTTFNMYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVEHKNVHATVKVPEVNSSALPHKLRIKAKAMQVKVEAMDNDYDATQKLSSPIDMSSKRHFELEKHGAQNLVHSSHTPFSVQVTNIQDWSLKPELWHQKELNVKIQNGCKTGVVEIKDNVYNVSESENLYLKQGIANLSAEVASLKRLITTQQISASDSG

nfil3

Nuclear factor interleukin-3-regulated protein

456 amino acids

May act as a transcriptional regulator of a number of proteins of the circadian clock.

Belongs to the bZIP family. NFIL3 subfamily.

50.864 kDa

MPTIKKEQECADSRMENILVLSSNIPDMSESMDSSNDMLYSDGLPVKNKSSSCRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDMVLENKLIALGEENASLKTELLSLKLKFGLISSTSYAQEIQKVTSSTAMYYQEYASSKSNMMSYNSDPEHSVMTSSCISVIKHSPQSSLSDVSEASSSVEHVQPSTIQSNCRSTDIKSQRIKQEQMEAGNFSRDAREESNTFQGSIYANYIGNTFSGYSHSPPLLHINRSSSNSPRTSEADEGVVGKTSDVEDEQQVPKGPIHSPIELKNGHATIIKVPEVNSSALPHKLRIKAKAMQIKVESLESELNSTQKLTLPIDMSSKQHLQLEKHNSESMVHSSLSPLSVQVTNIQDWPLKPGQWHHRELEKIPSVCKTSGIVAIKDNVYKASESESLYLKQGIATLSAEVASLKRLIVTQEICASNSS