Protein
Methionine aminopeptidase 2-2
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Sequence
MGSKSPEGHWQAPHASNSNELKPANPDPQTSQNGSGSADLDRGVIGDDDDDDEDAEENGVNTETPNVEKKKKRKKSNKKKKKKTKSGTLSVTELKQTSPPRVLVSTLFPSEYPVGELVPYDCTTRTTDEESRYNSRLWDDDFLPDYRQAAEIHRQVRQYAQKELIKPGATLLSIAEGIEDGVRALSGHQGLEPGDFFKAGMGFPTGLCLNHIAAHWTPNPREKDVILDKGDVLKVDFGVHVNGRIVDSAFTVAFDDKYDNLLTAVREATNTGIKHAGVDARMSDIGAAIQEVMESYEVEIDGKVFPVKAIRNITGHDILRYHIHGGKQIPFIKNNNQDKMEEGEVYAIETFGSTGRGFLDDDVGVYGYGRNENMSGANLRLSSAKSLLKTIDANFGSIVFSRRYLERLGVKNYLLGMKNLVDNGIVECYSPLVDVKGSYTAQFEHTILLHSGGKEVISRGDDY