Protein
Zinc finger CCCH domain-containing protein 19
Organism
Arabidopsis thaliana
Function
Plays a central role in integrating RNA silencing and chromatin signals in 21 nt siRNA-dependent DNA methylation on cytosine pathway leading to transcriptional gene silencing of specific sequences. Involved in a chromatin-based RNA silencing pathway that encompasses both post-transcriptional gene silencing (PTGS) (e.g. RDR1, RDR6 and AGO2) and transcriptional gene silencing (TGS) (e.g. siRNA-dependent DNA methylation and histone H3) components. Mediates siRNA accumulation at specific chromatin loci. Binds H3K4me0 through its PHD to enforce low levels of H3K4 methylation and gene silencing at a subset of genomic loci.
Sequence
MDSDSERASLESIKDNSECVHVSNEPNLTATCVDSSVGEEGVTDVNSSAAVSELVPPEQGEGALLNSVPEISERGIPVDVVSSVDGGGEENAAFNIQEIDSVGGDAAAVEEVPLKSSSVVGEGREEEAGASIVKEEDFVAEANLSGDRLEENKEVSMEEEPSSHELSVCEVNGVDSLNDEENREVGEQIVCGSMGGEEIESDLESKKEKVDVIEEETTAQAASLVNAIEIPDDKEVACVAGFTEISSQDKGLDESGNGFLDEEPVKELQIGEGAKDLTDGDAKEGVDVTEDEMDIQVLKKSKEEEKVDSTTELEIETMRLEVHDVATEMSDKTVISSAVVTQFTGETSNDKETVMDDVKEDVDKDSEAGKSLDIHVPEATEEVDTDVNYGVGIEKEGDGVGGAEEAGQTVDLEEIREENQELSKELAQVDETKISEMSEVTETMIKDEDQEKDDNMTDLAEDVENHRDSSVADIEEGREDHEDMGVTETQKETVLGKVDRTKIAEVSEETDTRIEDEDQEKDDEMTDVAEDVKTHGDSSVADIEEGRESQEEMTETQEDSVMADEEPEEVEEENKSAGGKRKRGRNTKTVKGTGKKKEEDVCFMCFDGGDLVLCDRRGCTKAYHPSCVDRDEAFFQTKGKWNCGWHLCSKCEKTATYLCYTCMFSLCKGCAKDAVFFCIRGNKGLCETCMETVKLIERKQQEKEPAQLDFNDKTSWEYLFKDYWIDLKTQLSLSPEELDQAKRPLKGHETNASKQGTASETDYVTDGGSDSDSSPKKRKTRSRSKSGSAEKILSSGDKNLSDETMEWASKELLDLVVHMRRGDRSFLPMLEVQTLLLAYIKRYNLRDPRRKSQVICDSRLQNLFGKSHVGHFEMLNLLDSHFLKKEQNQADDIQGDIVDTEEPNHVDVDENLDHPVKSGKDKKRKTRKKNVRKGRQSNLDDFAAVDMHNINLIYLRRSLVEDLLEDSTAFEEKVASAFVRLRISGNQKQDLYRLVQVVGTSKAPEPYKVGKKTTDYVLEILNLDKTEVISIDIISNQDFTEDECKRLKQSIKCGLINRLTVGDIQEKAIALQEVRVKNLLEAEILRFSHLRDRASDMGRRKEYPYLLKLSNSLTMLTLRECVEKLQLLKSPEERQRRLEEIPEIHADPKMDPDCESEDEDEKEEKEKEKQLRPRSSSFNRRGRDPISPRKGGFSSNESWTGTSNYSNTSANRELSRSYSGRGSTGRGDYLGSSDDKVSDSMWTSAREREVQPSLGSEKPRSVSIPETPARSSRAIAPPELSPRIASEISMAPPAVVSQPVPKSNDSEKIWHYKDPSGKVQGPFSMAQLRKWNNTGYFPAKLEIWKANESPLDSVLLTDALAGLFQKQTQAVDNSYMKAQVAAFSGQSSQSEPNLGFAARIAPTTIEIPRNSQDTWSQGGSLPSPTPNQITTPTAKRRNFESRWSPTKPSPQSANQSMNYSVAQSGQSQTSRIDIPVVVNSAGALQPQTYPIPTPDPINVSVNHSATLHSPTPAGGKQSWGSMQTDHGGSNTPSSQNNSTSYGTPSPSVLPSQSQPGFPPSDSWKVAVPSQPNAQAQAQWGMNMVNNNQNSAQPQAPANQNSSWGQGTVNPNMGWVGPAQTGVNVNWGGSSVPSTVQGITHSGWVAPVQGQTQAYPNPGWGPTGHPQSQSQSQVQAQAGTTGSGWMQPGQGIQSGNSNQNWGTQNQTAIPSGGSGGNQAGYWGNQQQSQNGDSGYGWNRQSGGQQNNFKGQRVCKFFRENGHCRKGASCNYLHN