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NEC2

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human cytomegalovirus (strain Merlin)
Length
398 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
43.052 kDa
Sequence
MEMNKVLHQDLVQATRRILKLGPSELRVTDAGLICKNPNYSVCDAMLKTDTVYCVEYLLSYWESRTDHVPCFIFKNTGCAVSLCCFVRAPVKLVSPARHVGEFNVLKVNESLIVTLKDIEEIKPSAYGVLTKCVVRKSNSASVFNIELIAFGPENEGEYENLLRELYAKKAASTSLAVRNHVTVSSHSGSGPSLWRARMSAALTRTAGKRSPRTASPPPPPPRHPSCSPTMVAAGGAAAGPRPPPPPMAAGSWRLCRCEACMGRCGCASEGDADEEEEELLALAGEGKAAAAAAGQDIGGSARRPLEEHVSRRRGVSTHHRHPPSPPCTPSLERTGYRWAPSSWWRARSGPSRPQSGPWLPARFATLGPLVLALLLVLALLWRGHGQSSSPTRSAHRD

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human cytomegalovirus (strain AD169)
Length
397 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
42.901 kDa
Sequence
MEMNKVLHQDLVQATRRILKLGPSELRVTDAGLICKNPNYSVCDAMLKTDTVYCVEYLLSYWESRTDHVPCFIFKNTGCAVSLCCFVRAPVKLVSPARHVGEFNVLKVNESLIVTLKDIEEIKPSAYGVLTKCVVRKSNSASVFNIELIAFGPENEGEYENLLRELYAKKAASTSLAVRNHVTVSSHSGSGPSLWRARMSAALTRTAGKRSSRTASPPPPPRHPSCSPTMVAAGGAAAGPRPPPPPMAAGSWRLCRCEACMGRCGCASEGDADEEEEELLALAGEGKAAAAAAGQDVGGSARRPLEEHVSRRRGVSTHHRHPPSPPCAPSLERTGYRWAPSSWWRARSGPSRPQSGPWLPARFATLGPLVLALLLVLALLWRGHGQSSSPTRSAHRD

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Epstein-Barr virus (strain B95-8)
Length
336 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
37.632 kDa
Sequence
MASPEERLLDELNNVIVSFLCDSGSLEVERCSGAHVFSRGSSQPLCTVKLRHGQIYHLEFVYKFLAFKLKNCNYPSSPVFVISNNGLATTLRCFLHEPSGLRSGQSGPCLGLSTDVDLPKNSIIMLGQDDFIKFKSPLVFPAELDLLKSMVVCRAYITEHRTTMQFLVFQAANAQKASRVMDMISDMSQQLSRSGQVEDTGARVTGGGGPRPGVTHSGCLGDSHVRGRGGWDLDNFSEAETEDEASYAPWRDKDSWSESEAAPWKKELVRHPIRRHRTRETRRMRGSHSRVEHVPPETRETVVGGAWRYSWRATPYLARVLAVTAVALLLMFLRWT

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Equine herpesvirus 2 (strain 86/87)
Length
287 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
31.241 kDa
Sequence
MNGSKRLVAQLCQVVRSFICQPGTAVDLWQCAAGPHVFAKGSTQPICIVKLVHGQIYNLEFVYKYWCHILQSEKFPYSPVFIISNNGLAITLKCFLCEPMDLHSQFGRCLSMDTDVYLPKNTSVVLSQDDFTKFKTNLVFSKDLNVFNSMVVCRTYLTDFRQALQFLVVKAKNPKRVTAILGTIAQTLGLTPDTRSGEGGKNSERGEDDMVRRPIRAHRAGDSGGSPGTLPAEPQGAPTPPGGGLGLSSGLGLVRRWTRCAFQRYFTVLAVGAVAAATFLAGAKLTG

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)
Length
277 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
30.71 kDa
Sequence
MEVIPNINSRRAGLIARIKLIVRGDLTTGNYDPVLAESFSGCIPTRSAFQFSGADGVESAFPVEYVMRMMNDWAKGECNPYIKIQNTGVSVLIEGFFDPPINATKAPLCTDKVNVLLNTTESTGIVLSDINKIKQSIGVDCRPFQACLIVNCFVRLPIVQLAFRFVGPSDPGRTTKLLDSAIAAYDAKIRQRRKRNLQIMESKSQDHTSDGCIPIPIIDETHRSGITGESKSLFGMFKNIASGECVTTIRIPRYIVMLWIFSVLLAMVTWGSYRLYS

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 2 (strain HG52)
Length
276 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.524 kDa
Sequence
MAGMGKPYGGRPGDAFEGLVQRIRLIVPATLRGGGGESGPYSPSNPPSRCAFQFHGQDGSDEAFPIEYVLRLMNDWADVPCNPYLRVQNTGVSVLFQGFFNRPHGAPGGAITAEQTNVILHSTETTGLSLGDLDDVKGRLGLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAVRTRRILCRAAEQALARRRRSRRSQDDYGAVVVAAAHHSSGAPGPGVAASGPPAPPGRGPARPWHQAVQLFRAPRPGPPALLLLAAGLFLGAAIWWAVGARL

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 6A (strain Uganda-1102)
Length
276 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
31.671 kDa
Sequence
MANVLKEKMYDELLSATCRILKLGSHDYRITERNLLSKNPKFPLCDIILKLDYAYNLEYLLSLWEHVTKQEPRFVFKNTGGAVSMSCYLHAPVKVEGHHAVRECNILRVNECLTVRMSDIVAMKPSTFAVFTKCIIRRNRDDTYVVEFVAFGPENESEYISLLKAIFLKKCSMGKQHLESNRFCQGLRRRSSHVLEKGRFESSGKVVNKASAVVTSQESIKQFYEKEKSLLSGVKFWRLSERHCRFALVGICFLLALYFCYVLLKKTPTPASGSVV

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 6B (strain Z29)
Length
276 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
31.441 kDa
Sequence
MANVLKEKMYDELLSATCRILKLGSHDYRMTERNLLSKNPKFPLCDIILKLDYAYNLEYLLSLWEHVTKQEPRFVFKNTGGAVSMSCYLHAPVKAEGHHAVRECNILRVNECLTVRMSDIVAMKPSTFAVFTKCIIRRNRDETYVVEFVAFGPENESEYISLLKAIFLKKCSMGKQHLESNRFCQGLRRRSSHVLEKGQLGSSGEIANKASAVVTSQESINQFYEKEKSFLSGVKFSRLSERHCRVAIVSICFLLALYFCYVLLKKTPTPASGPVV

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Equine herpesvirus 1 (strain Ab4p)
Length
275 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
30.68 kDa
Sequence
MDSYNYRDFAVGGGLLQRIRLVVSGSLHCGESDATLNDPKHLPARCVFQFSGPDNNSVTFPIEYVLRLMKNWARSQCDPYIRIQNTGVSVLFQGFFFAPPNAPMASITSEHNNVILKSTHTTGLALSGIERVKRGGGLDLRPLQAMMQISCFTRMPVVQLSFRFMGPEDASRTQRLLERATSFGAMELHQKRTVDSCDRSNGIVSPREHRECRERQKRRPTPKRCASEVFASLASISSAFASERVKRRPVRIAAAILAFVFVAVILAIATKGRLF

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Equine herpesvirus 1 (strain V592)
Length
275 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
30.68 kDa
Sequence
MDSYNYRDFAVGGGLLQRIRLVVSGSLHCGESDATLNDPKHLPARCVFQFSGPDNNSVTFPIEYVLRLMKNWARSQCDPYIRIQNTGVSVLFQGFFFAPPNAPMASITSEHNNVILKSTHTTGLALSGIERVKRGGGLDLRPLQAMMQISCFTRMPVVQLSFRFMGPEDASRTQRLLERATSFGAMELHQKRTVDSCDRSNGIVSPREHRECRERQKRRPTPKRCASEVFASLASISSAFASERVKRRPVRIAAAILAFVFVAVILAIATKGRLF

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 1 (strain 17)
Length
275 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.79 kDa
Sequence
MAGLGKPYTGHPGDAFEGLVQRIRLIVPSTLRGGDGEAGPYSPSSLPSRCAFQFHGHDGSDESFPIEYVLRLMNDWAEVPCNPYLRIQNTGVSVLFQGFFHRPHNAPGGAITPERTNVILGSTETTGLSLGDLDTIKGRLGLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAGRTRRILCRAAEQAITRRRRTRRSREAYGAEAGLGVAGTGFRARGDGFGPLPLLTQGPSRPWHQALRGLKHLRIGPPALVLAAGLVLGAAIWWVVGAGARL

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)
Length
274 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.694 kDa
Sequence
MRSDKYSQLVSVVNAGLGACGTSATLVYIRNNARVAPTGDIITLPARLDGPPIPAEYILEAMTSLLSIRTAWLRIQNTGQAVIVAGCSTQNFHHGDVTWEPPASTVTLTTAKSLWVSASAVREMKVIQRIRTAPLAAMMFMCFYRGGKNEVTVRFAFYKSDSEPNLLKISKCVYEAIDAEATRNLPKPRGFDTPPCAVLAQRMRPLGAAEGGDRETSAQTHSPAAQAQHVMQHATATKSWGALGRTLKHKKNLGWILFTCALSLAAAFVTAYIK

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 8 type P (isolate GK18)
Length
271 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.849 kDa
Sequence
MSVVGKRVVDELCRVVSSYLGQSGQSLDLERCIDGAPVYAKGGATAICTVRMQHGCVYHLEFVYKFWAHLLEEMHYPFSPCFVISNNGLSTTLKCFLCRPSDAVSQFGHVLPVESDVYLAKNTSVVLGQDDFTKFKASLVFSKNLGVYNSMVICRTYFTDYRQVLQFLVVTPKSHKRLKSLLETVYCLAAPVADSAAQGGAGFPTNGRDARACTSDVTAVYWAGQGGRTVRILGAFQWSLGRAVALVRRSWPWISAGIAFLCLGLVWMRPS

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Varicella-zoster virus (strain Dumas)
Length
269 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
30.452 kDa
Sequence
MSRRTYVRSERRRGCGDNLLQRIRLVVPSALQCCDGDLPIFDPQRPPARCVFQFNGEDNVSEAFPVEYIMRLMANWAQVDCDPYIKIQNTGVSVLFQGFFFRPTNAPVAEVSIDSNNVILSSTLSTGINLSALESIKRGGGIDRRPLQALMWVNCFVRMPYVQLSFRFMGPEDPSRTIKLMARATDAYMYKETGNNLDEYIRWRPSFRSPPENGSPNTSVQMQSDIKPALPDTQTTRVWKLALPVANVTYALFIVIVLVVVLGAVLFWK

Gene
NEC2
Protein
O-methyltransferase NEC2
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
265 amino acids
Function
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of nectriapyrone and its analogs phomopyrone A, acropyrone and zaepyrone (PubMed:30443971). The nectriapyrone biosynthetic gene cluster consists of two genes, the highly reducing polyketide synthase NEC1 that produces a demethylated analog of nectriapyrone from one unit of acetyl-CoA and one unit of malonyl-CoA; and the O-methyltransferase NEC2 that further methylates the NEC1 product to yield nectriapyrone (PubMed:30443971). Nectriapyrone is further hydrolyzed to nectriapyrone D, also known as gulypyrone B, by an unidentified hydrolase localized outside the nectriapyrone cluster (PubMed:30443971).
Similarity
Belongs to the methyltransferase superfamily.
Mass
29.68 kDa
Sequence
MASSRDRAYVTVYSPTLLTWVYDYYVLGFNLRYIWGCPTDAVLLPFFAENFSRRHLDVGVATGYLPARVLASPWRRAAAHRQHLTLLDINANSLRASDARVRAAAPGIETTCVEADVVADLPPVLASVVEEERARVEKAGGEAGSSSRSCLYDSISMFNLFHCVPGGPAKLRAISTYKALLADHGVLSGCTVLGERHATGWFSRWYLRLYNRKGIFNNINDTREEFEEVLNKEFEEVDTWMFGMVLLFRASKPRREGSGYVDLLA

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Alcelaphine herpesvirus 1 (strain C500)
Length
263 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.158 kDa
Sequence
MASGKKLIDQLCSVVSSFLCPSISSLDIDRCAVGPHIFSRGSSQAICTVKLLHGEVYNLEFVYRYWAHILEKYNFPFSPTFIICNNGLAVTLKCYVSEPRDLSSRYGQATSMALDVNLQRNSFVVLSQDDFIKFKTPLVFAKDLDITNSMVVCRTYLTSSRNSLQFLVVKSKNPRRLENVLDMIKRAVEATGSNLPATREKPLPLEQTEQLESTLPSSGHLRVLQSTSLTGRCPSWGAACALLLLSLAVGLMAILAAKLMQWP

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Human herpesvirus 7 (strain JI)
Length
258 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
29.29 kDa
Sequence
MLKEKMYDELILSTCRVLKLGPADFRVTDKNLFSKNPKFPLCDILLKLDFAYSLEYLLSLWEDLTKQEARFIFKNTGGAVSMSCYLHAPIKQESQNIVKECNILNVNECLSVCLNDIEAIKPSSSGVLTKCIIRRNRDAAFIVEFVAFGPESESEYIALLKAIILKKKFLERQDLEKHRAARHIKKPLRLQLKSVGEMTSFRSINYMGNTKDAAVFPVTVPIFARRNNILCGFLVAALLIVCYVIFKEFALSADFSAV

Gene
NEC2
Protein
Nuclear egress protein 2
Organism
Saimiriine herpesvirus 2 (strain 11)
Length
235 amino acids
Function
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Similarity
Belongs to the herpesviridae NEC2 protein family.
Mass
26.886 kDa
Sequence
MNSTRLVYELCDIVNLYLCQPGVQIDVDRCASGPHVFTKGGTEAICTVKLSHGLVYNIEFVYKFWAHKLESVKYPFSPCFIISNNGLATTLKCFLSRPRNVNHFGHVLNIDSDVYLTKNTSVILSQDDFVKFKTNLVFSKDLDVFHSMVVFRTYLIEHRQALQFLVVKPRSSKRVNSILSSVAKTASQNFILDPPRRSEETRVCIKPWTLSKKNIWTIILSLVAVVAIILKWREL