ncbp3

Nuclear cap-binding protein subunit 3

694 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.

Belongs to the NCBP3 family.

78.338 kDa

MAAVRSLRVSVKSDSASDRSESDSESDSDRDAREAEPMEVEEGEVELESIPVRRSLKELLPDTSRRYENKAGTFITGIDVTSKEAIEKKEKRARRFHFRAEENLTQKDVVLERDLLKKMIPKVRLEALHMSGVDDMSTQDVFGYFKEYPPAHIEWIDDASCNVVWLDDITSTRALINLSRMPDKEEVTNTDSSKPSELPVQTQKARRSRGSDDDDDDDEEEEGEVDDDDDDDEEDEKARDIEDETEKKPQETRETSLSQAERDSLLQNEPRPTVKPFKGNKLFLRFATHDDKKELGAARRSRYYMKYGNPNYGGMKGILSNSWKRRYHTRRIQRDILKTKKPLIGDSMGHTPPYTHRHSADLVNLPEEPIEEEEEEEEDGEEDMDADDRVVEYKDRGEKERGPRLVEGGLRSRLGGPSPTSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVETNLRSLRNSIRTESSGSVKSRIGGGGGGGSGGAVEGRGEGGSSKSTSEKVTDVRQLLEEKRQGLSQQRSRPPVATSGKTDVRQRLGKRPHSPERRRSVSPVISRKTASRREPLSDVRSRLGVAKHDNRSLFSEPPKDKKTGGLWSRLGPSHKDSGSGDEDKPSSRASSSRGIRRRKDEDSDGVEDEDEEDDSHLQKMWGAMIKQKEQQSNKMKKSRLDNLPSLQIEISRDGSNGSDSDS

NCBP3

Nuclear cap-binding protein subunit 3

620 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).

Belongs to the NCBP3 family.

70.593 kDa

MAAVRGLRVSVKAEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRRSLKELIPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRSEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDVFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKIRSRDASEDKSAEKRKKDKQEDSSDDDEAEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEEEEEEDQDMDADDRVVVEYHEELPALKQPRERSASRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKNIRNSMRADSVSSSNIKNRIGNKLPPEKFADVRHLLDEKRQHSRPRPPVSSTKSDIRQRLGKRPHSPEKAFSSNPVVRREPSSDVHSRLGVPRQDSKGLYADTREKKSGNLWTRLGSAPKTKEKNTKKVDHRAPGAEEDDSELQRAWGALIKEKEQSRQKKSRLDNLPSLQIEVSRESSSGSEAES

ncbp3

Nuclear cap-binding protein subunit 3

618 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.

Belongs to the NCBP3 family.

69.741 kDa

MAAVRGLRVSVKAGGGAEPEPMEVEEGEVEAAAGRTSPVEATADQTSPREVVPGSDRRYENRAGTFITGIDVTSKEAIEKKEQRAKRFHFRAEVSDDQRNVVLDREMMRKVPKVRLETLYICGVDEMSTQDIFAFFKQYPPGYIEWLDDSSCNVVWLDEVTASRALLNLSSKPTNEKGQRKKDGEHRSARSKKDRLDDSPQSSGDETEEGEVEEDNPNDAEVETENKSENPPETLSQAEQASILKNDLRPSIKTVKGNRLYMRFATKDDKKEHGAASKSQYYMKYGNPNYGGMKGILSNSWKKRYHSRRIQRDVIKKRTFIGDDVGLTPTYKHHHSGLVNVPEEPIEEEEEEEEEEEEDMDEDDRVVEYRDELQAFKREREGARRCAASNSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKTIRHSMRSDSAGNSVKSRIGSKSHSEKPADVRLILEEKRQSTASRQQSSSSGKSDVRQRLGKRAHSPEIRKTLSIAPTSRREPLSDVHSRLGLPKQPEGKGLYSDSKEKKTGSLWNRLGTAPKEKDRASEKSGEKSQAAPEEEDSALQQAWGALIKEKEQIRQKKSRLDNLPSLQIEISRESSSGSDTDS

Ncbp3

Nuclear cap-binding protein subunit 3

615 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).

Belongs to the NCBP3 family.

70.043 kDa

MAAVRGLRVSVKAEAPAGPALGLPSPEVESGLERGEPEPMEVEEGELEIVPVRRSLKELLPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRAEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDIFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKMRSRDASEDKSSEKNKKDKQEDSSDDDETEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEDQDMDADDRVVVEYHEELPGLKQPRERSLSRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKSIRNPMRADSISTSNIKNRIGNKLPPEKFADVRHLLDEKRQHSCPRPAVSSTKPDIRQRLGKRPYSPEKAFSSNQVVRREPSSDVHSRLGVPRQDVKGLYSDTRERKSGGLWTRLGSTPKTKEKNTKKVDHRASGAEEDDSELQRAWGALIKEKEESRQKKSRLDSLPSLQIEVSRESSSGSEAES

ncbp3

Nuclear cap-binding protein subunit 3

611 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.

Belongs to the NCBP3 family.

69.124 kDa

MAAVRGLRVSVKAGGGAEPEPMEVEEGEVEAAADRASPREVVSGSNRRYENRAGTFITGIDVTSKEAIEKKEQRAKRFHFRAEVSDQQRNVVLDREMIRKAIPKVRLETLYVYGVDDMSTEDIFAFFKQYPPGYIEWLDDSSCNVVWLDEVTPSRALLNLSSMPTNEKGQRKKDGEHSSARSKKDRLDDSPLSSGDETEEGEVEEDNPSEAEDEDETETEKKSVNPPDTLSEAEQASLLKNELRPSSKPVKGNSLYMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRLQRDVIKKSTFIGDDVEITPTYKHLHSGLVNVPEEPIEEEEEEEEEEEDMDEDDRVVVEYRDELQAFKREREGARRSAASNSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKTIRNSMRSDSVGNSVKSRIGSKSHAEKPADVRLILEEKRQSTASRQQSSSGKSDVRQRLGKRPHSPEIRKTLSIAPTSRREPLSDVHSRLGLPKQLEGKGLYSDSKEKKTGSLWNRLGTAPKDKERPSEKSEKSPAAPEEEDSVLQQAWGALIKEKEQIRQKKSRLDNLPSLQIEISRESSSGSDTDS

NCBP3

Nuclear cap-binding protein subunit 3

604 amino acids

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.

Belongs to the NCBP3 family.

68.726 kDa

MAAVRGLRISVKAEATATTAEPRGPEPEPMEVEEGELETIPVRRSLRELIPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRAEVNLAQRNVALDRDMMKKAIPKVRLDTIYICGVDEMSTQDIFAYFKEYPPAHIEWLDDTSCNVVWLDEVTATRALINMSSFPDQEKPKGGENNEEKTAEKNKKEKQEESTDDETEEGEVEDENPSDIELDALTQVEEDSLLRNDLRPANKLAKGNKLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIHRDVIKKRTLIGDDVGLTPPYKHRHSGLVNVPEEPIEEEEEEEEVQDMDEDDRVVVEYRDDLQPFKQSRDRGAARRSSASASDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKNIRNSMRADSIATSNVKNRIGSKGLSDKVVDVRLLLEEKRQNNNGLRQPNSIVKSDVRQRLGKRPHSPEVKPPSSISAPRREPISDVHSRLGIPKQDVKGLYSDTREKKSGNLWTRLGSAPKTQEKTSDKPENSVASPEEDDSELQRVWGALIKEKGESRQKKSRLDNLPSLQIEISRESSSGSDTES