NCAPH

Condensin complex subunit 2

741 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

Belongs to the CND2 (condensin subunit 2) family.

82.563 kDa

MGPPGPALPATMNNSSSETRGHPHSASSPSERVFPMPLPRKAPLNIPGTPVLEDFPQNDDEKERLQRRRSRVFDLQFSTDSPRLLASPSSRSIDISATIPKFTNTQITEHYSTCIKLSTENKITTKNAFGLHLIDFMSEILKQKDTEPTNFKVAAGTLDASTKIYAVRVDAVHADVYRVLGGLGKDAPSLEEVEGHVADGSATEMGTTKKAVKPKKKHLHRTIEQNINNLNVSEADRKCEIDPMFQKTAASFDECSTAGVFLSTLHCQDYRSELLFPSDVQTLSTGEPLELPELGCVEMTDLKAPLQQCAEDRQICPSLAGFQFTQWDSETHNESVSALVDKFKKNDQVFDINAEVDESDCGDFPDGSLGDDFDANDEPDHTAVGDHEEFRSWKEPCQVQSCQEEMISLGDGDIRTMCPLLSMKPGEYSYFSPRTMSMWAGPDHWRFRPRRKQDAPSQSENKKKSTKKDFEIDFEDDIDFDVYFRKTKAATILTKSTLENQNWRATTLPTDFNYNVDTLVQLHLKPGTRLLKMAQGHRVETEHYEEIEDYDYNNPNDTSNFCPGLQAADSDDEDLDDLFVGPVGNSDLSPYPCHPPKTAQQNGDTPEAQGLDITTYGESNLVAEPQKVNKIEIHYAKTAKKMDMKKLKQSMWSLLTALSGKEADAEANHREAGKEAALAEVADEKMLSGLTKDLQRSLPPVMAQNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVRQGD

Ncaph

Condensin complex subunit 2

731 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

Belongs to the CND2 (condensin subunit 2) family.

82.303 kDa

MRIPRSETMNSSFLKARGQQDVLSSPLERVPPASRPGKAPLGTPKTPVLEDFPQNDDEKERMQRRRSRVFDLQFSTDSIHLASPNRNIDVSTTISKFTNTQITEHYSTCIKLSSENKITTKNAFGLHLIDFMSEILKQKDAEPTNFKVAAGTLDASTKIYAVRVDAVHADVYRVLGGLGKDTPPQGEESHSGDGSTLETERTKKPAKPKKKQSCKTIEQNLSNINVSEADGKCAVDPMFQKTAASFDECSTTGVFLSTLHCQDYRSELLFPSDMQTLSSGEPLELPDLGFVDMTDLEASLQQCVEDRPLCPSLAGFQFTKWDSETHNESVSALVDKFKKNDQVFDINAEAEDDEEDVPDGPLVEDFVDNDEPDLSAAGDHEEFRSWKELCQVQSNQEEVISLEDRDIQVMCSFLSMKPGEYSYFSPRTMKMWAGPDHWRFRPRPKQDATSCTEHKKKSAKKDFEINFDDDIDFDAYFQKTKAATILTKSTLENQNWKATTLPTDFHYETDNLIQLHLKPGKRSLKMDQDQKAKTEHYEEIEDYDYNNPNDTSNYCPGLQAADSDYEEADDLFADPVGTLDLESDPKTTQENGHISPENQGVDITTYQELNLVAEPQKVNKIEIHYAKTAKKMDMKKLKQSMWSLLTKFSRKEADTEANHTESGQEGAPEEVADEKKLSGLTKDLQTRLPPLMAQNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVMQGD

ncaph

Condensin complex subunit 2

699 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.

Belongs to the CND2 (condensin subunit 2) family.

77.778 kDa

MSTSTPQSGGRRKPETPDSAFLSPATRPQPISAAATPTLLNFTSNDDERERKLRRMSRVIDLQLSNANSPATAISPAQSRGADTPTSLLPKLNNTQISDHYSTCIKLSQENKITTKNAFGLHLIDYMGDILKHKDSELTNFKVAAGTLDASAKIYAVRVDAVHADVYKVLGGLGKESQATEDTENQETDTGPQDGRKNPKRRKCSYKTIERNLNSINRSETERKSEIDPLFQKAAASFDEFSTAGVFLSTLKCHSYHSELHFDADVKPLSTAEETEPPSPGSMDSTELKSLFLQCVEKRPLCPSLSGFRFMQWNSDAQNENLSLLMDKFKKSDHVFDINAEVEDDFVESEAPVADEFDADVCEGMDAGDIGEFAEHREACRLERKGAQLTQIGNGDIGTMCLQLSSCPGEYSYFSPRTMSMWAGPEHWRFRPRQKASTDSDQQRVKKAKKVFELNFEDDIDFEVHFRKTRAATTLTKSTLESQNKKSTTLPADFHYDPDNIARMSLRPKDRIRKTTVQESVSEPEDDIGDYDYNNPNDTSNFCPALQAADSDDDDGAFLGPESNSAGFSAENQMNITSYGESNLVAGQKVNKIEIQYAKTAKKMDMKRLKSSMWSLLANCPESQEEMPSSKEEIDAALITDEQVFSSVTHGLQKRLPPVMAQNLSVPLAFACLLHLANEKNLKLQGMDDLSDVMIMQDD