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NAT10

Gene
nat10
Protein
RNA cytidine acetyltransferase
Organism
Dictyostelium discoideum
Length
1057 amino acids
Function
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Similarity
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Mass
120.004 kDa
Sequence
MVRKKVDTRIRTLIENGVATNHRSFFVIVGDNGKDQVPNLHYILSKSIVKARPSVLWCYKEDLGFSKHKKKKMKLKEKSKSSGIDSVNQEDPFDVFISTTNIRYSYYSESHKILGNTFGMLVLQDFEAITPNLLARTIETVEGGGLIVLLLKTMDSLKQLYTMTMDVHTRFRSENSKGEVVCRFNERFLLSLGKSEQCLVMDDELNILPISSQSRSIEAKQQILETPEQVELREFKQQVKDTDIAGALIENTKTMDQATALLTFIDSISEKTLRSTVTLTAGRGRGKSAALGLAISAAVAFGYSNIFVSSPTPENLNTLFQFVFKGFDSMEYVEHVDYELVKSTNPEFHDAIIRVNIFRSHRQTIQYIQPQDYQKLGQAELVVIDEAAAIPLPLVKNLLGPYLVFMSSTINGYEGTGRSLSLKLIKQLREQSTVVSNSSNKALNSITGRMLREIELNEPIRYSARDPIERWLNELLCLDSTIAKSSPTGCPHPSACQLYYVNRDTLFSYHKASEAFLQKMVGLFVSSHYKNSPNDLLLMSDAPDHHLFVLLGPIDENNTTGLPEILCAVQVSLEGEIAKESILNSIKRGYQASGDLIPWTLTQQYQDEDFPRLSGVRIVRIATHPDYQKMGYGSKALELLTQYYQGEITNLDEVNQEEEEEDEEKVDQNKGSSKISTVKKDNASLLTEVIRPKSNIPPLLFKLSERKPEKLHYMGVSYGLTQQLYQFWSKSKYLPVYLRLTSNDITGEHTCIMLRELNNEQNNTICKDGWLQSFHQDFKKRFINLLGYEFRNFNSSIALNILYEKKVNNTVAVASSTTKNELTQNEMELLFSSYDLKRLESYSNNIVDYHVVIDLLPSLSKLYFTNKLKIEDISLIQSAILLALGLQHKTVDNLIGELNLASNQVLSLFNQTMRKINTELKQKQEKFIQDSMPKLSIVAPRTGQFKSFKGDIKETDMIPLAEDMESELEKGAEEVVNKLKHQLENDSSLSKYLVKGNDEDWSKALKPGSIPNSITIKRKSDENEETDKKENNKKSKTKNNNNNNNNNKKVNNQKSKK

Gene
nat10
Protein
RNA cytidine acetyltransferase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1033 amino acids
Function
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1297 and 1815 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25402480). Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein tan1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (By similarity).
Similarity
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Mass
116.463 kDa
Sequence
MPKKALDSRIPTLIKNGCQEKQRSFFVVVGDRARDQVVNLHWLLSQSKVAARPNVLWMYKKDLLGFTSHRKKRENKIKKEIKRGIRDPNSEDPFELFCSITNIRYCYYKESEKILGQTYGMLVLQDFEALTPNLLARTIETVEGGGIVVLLLHKLNSLKQLYTMSMDIHSRYRTEAHSDVTARFNERFILSLGNCENCLVIDDELNVLPISGGKNVKALPPTLEEDNSTQNSIKELQESLGEDHPAGALVGVTKTLDQARAVLTFVESIVEKSLKGTVSLTAGRGRGKSAALGLAIAAAIAHGYSNIFITSPSPENLKTLFEFIFKGFDALNYEEHVDYDIIQSTNPAYHNAIVRVNIFRDHRQTIQYISPEDSNVLGQAELVVIDEAAAIPLPLVRKLIGPYLVFMASTINGYEGTGRSLSLKLLQQLREQSRIYSGSGNNKSDSQSHISGRTLKEISLDEPIRYAMGDRIELWLNKLLCLDAASYVSRMATQGFPHPSECSLYRVSRDTLFSYHPISEAFLQRMMSLYVASHYKNSPNDLQLMSDAPAHQLFVLLPPVDLKNPKLPDPICVIQLALEGSISRESIMNSLSRGQRAGGDLIPWLISQQFQDENFAALGGARIVRIAVSPEHVKMGYGTRAMQLLHEYFEGKFISASEEFKAVKHSLKRIGDEEIENTALQTEKIHVRDAKTMPPLLLKLSELQPEPLHYVGVSYGLTPSLQKFWKREGYCPLYLRQTANDLTGEHTCVMLRVLEGRDSEWLGAFAQNFYRRFLSLLGYQFREFAAITALSVLDACNNGTKYVVNSTSKLTNEEINNVFESYDLKRLESYSNNLLDYHVIVDLLPKLAHLYFSGKFPDSVKLSPVQQSVLLALGLQYKTIDTLEKEFNLPSNQLLAMLVKLSKKIMKCIDEIETKDIEEELGSNKKTESSNSKLPEFTPLQQSLEEELQEGADEAMLALREKQRELINAIDLEKYAIRGNEEDWKAAENQIQKTNGKGARVVSIKGEKRKNNSLDASDKKTKEKPSSKKKFRK

Gene
NAT10
Protein
RNA cytidine acetyltransferase
Organism
Homo sapiens
Length
1025 amino acids
Function
RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603).
Similarity
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Mass
115.73 kDa
Sequence
MHRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHMLSKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKNGTLNIKQDDPFELFIAATNIRYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQLYTVTMDVHSRYRTEAHQDVVGRFNERFILSLASCKKCLVIDDQLNILPISSHVATMEALPPQTPDESLGPSDLELRELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTLRSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQYQEHLDYEIIQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVIDEAAAIPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQSQVSTTAENKTTTTARLASARTLYEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELYYVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPTQNALPEVLAVIQVCLEGEISRQSILNSLSRGKKASGDLIPWTVSEQFQDPDFGGLSGGRVVRIAVHPDYQGMGYGSRALQLLQMYYEGRFPCLEEKVLETPQEIHTVSSEAVSLLEEVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDLTGEHSCIMLKTLTDEDEADQGGWLAAFWKDFRRRFLALLSYQFSTFSPSLALNIIQNRNMGKPAQPALSREELEALFLPYDLKRLEMYSRNMVDYHLIMDMIPAISRIYFLNQLGDLALSAAQSALLLGIGLQHKSVDQLEKEIELPSGQLMGLFNRIIRKVVKLFNEVQEKAIEEQMVAAKDVVMEPTMKTLSDDLDEAAKEFQEKHKKEVGKLKSMDLSEYIIRGDDEEWNEVLNKAGPNASIISLKSDKKRKLEAKQEPKQSKKLKNRETKNKKDMKLKRKK

Gene
Nat10
Protein
RNA cytidine acetyltransferase
Organism
Mus musculus
Length
1024 amino acids
Function
RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation. mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency. Mediates the formation of ac4C at position 1842 in 18S rRNA (By similarity). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (By similarity). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. The relevance of the protein lysine acetyltransferase activity is however unsure in vivo. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (By similarity).
Similarity
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Mass
115.419 kDa
Sequence
MNRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHMLSKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGTLNLKQDDPFELFVAATNIRYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQLYTMTMDVHSRYRTEAHQDVVGRFNERFILSLASCKKCLVIDDQLDILPISSHVASIEALPPQAPDENLSPAALELLELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTLRSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQYQEHLDYEIVQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVIDEAAAIPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQSQVSTTAENKTTTTARLASARTLHEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELYYVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPTQNALPEVLAVVQVCLEGEISRQSILNSLSRGKKASGDLIPWTVSEQFQDPDFGGLSGGRVVRIAVHPDYQGMGYGSRALQLLQMYYEGKFPCLEEKVLETPQEIRTVSSEAVSLLEEVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDLTGEHSCIMLKTLADEDEAEQGAWLAAFWKDFRRRFLALLSYQFSTFSPALSLNIIQNRNVAKSALPALGREHLEALFLPYDLKRLEMYSRNMVDYHLIMDLIPAISRLYFLNQLGDLSLSAAQSALLLGIGLQHKSVDQLEKEIELPSGQLMGLFNRIIRKVVKLFNDVQEKAIEEQMVAVKDVVMEPTMKTLSDDLDEAAKEFQEKHKKEVGKLKDMDLSQYVIRGDDEEWNEVLSKAGQNASIVSLKSDKKRKLETKQEPKQSKKLKKRDNNRKDMKLKRKK

Gene
NAT10
Protein
Putative nucleobase-ascorbate transporter 10
Organism
Arabidopsis thaliana
Length
541 amino acids
Similarity
Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
Mass
60.348 kDa
Sequence
MTNGGGGNNGAANRTEELQPHPVKEQLPGIQYCVNSPPPWLEAVVLGFQHYLLSLGITVLIPSVLVPLMGGGYAEKVKVIQTLLFVSGLTTLFQSFFGTRLPVIAVASYAYIIPITSIIYSTRFTYYTDPFERFVRTMRSIQGALIITGCFQVLICILGVWRNIVRFLSPLSIAPLATFTGLGLYHIGFPLLARCVEVGLPGLILLIFVTQYLPRFLKMKKGVMILDGSRCDRYGMILCIPLVWLFAQLLTSSGVYDHKSHTTQTSCRTDRTGLITNTPWIYIPYPFQWGSPTFDITDSFAMMAASFVTLFESTGLFYASARYGSATPIPPSVVSRGTCWLGVGVLLNGMLGGITGITTSTENVGLLAMTKIGSRRVIQISAAFMIFFSIFGKFGAFFASIPLPIMASLYCIVLCFVSSVGLSYLQFCNLNSFNIKFILGFSFFMAISIPQYFREYYNGGWRSDHHSNWLEDMIRVIFMSHTTVAAIIAIVLDCTLCRDSDEAKKDCGMKWWDKFRLYNLDVRNDEFYGLPCRLNKFFPSH