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NASP

Gene
NASP
Protein
Nuclear autoantigenic sperm protein
Organism
Homo sapiens
Length
788 amino acids
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Similarity
Belongs to the NASP family.
Mass
85.238 kDa
Sequence
MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC

Gene
NASP
Protein
Nuclear autoantigenic sperm protein
Organism
Bos taurus
Length
777 amino acids
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Similarity
Belongs to the NASP family.
Mass
83.688 kDa
Sequence
MAAESTATAAITAELVSADKIEEDAPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEEESLVENNDNIDEEAREELREQVYDAMGEKEAQKTEDKSLVKPEMDKEQETEMEKGGREDMDIGEPAEELQEKVKSAPDQLTETTEEGKGAAAPEGLSEAEVTSKKPDQEIPGAEEGKSVSETDVQEECREKGGQGEVIVSIEEKPKEASKEQPVVTLEKQGTPVEIEAVKPVDMGGDEPKEQVAASESERGKAILEQLVGQELPSAEESPEVTTQAADASAAEAGSEVSEKPGGQDTVLPQDGAVNGLSAAGDHASTKPQTNAEGLIGTKDGSALEKVRAELVPSQETKLSVEESEAAGDGVETEVAQGATEQSPEDKVKIAANEEAQDKEEQMKEGEETEGSEEEDKENDKAEETLNDSALENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQDTKEAQLYAAQAHLKLGEVSVESENYLQAVEEFQACLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEKRMAVLNEQMKEAEGSPTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGGSSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDTISTGTEVAENMEEEAENKAESRAAVEGTVEAGATVESTAC

Gene
Nasp
Protein
Nuclear autoantigenic sperm protein
Organism
Rattus norvegicus
Length
776 amino acids
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Similarity
Belongs to the NASP family.
Mass
84.2 kDa
Sequence
MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC

Gene
Nasp
Protein
Nuclear autoantigenic sperm protein
Organism
Mus musculus
Length
773 amino acids
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Similarity
Belongs to the NASP family.
Mass
83.954 kDa
Sequence
MATESTAAAAIAAELVSADKIEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGKSLTKPETDKEQESEVEKGGREDMDISEPEEKLQETVEPTSKQLTESSEEAKEAAIPGLNEDEVASGKTEQESLCTEKGKSISGAYVQNKEFRETVEEGEEIISLEKKPKETSEDQPIRAAEKQGTLMKVVEIEAEIDPQVKSADVGGEEPKDQVATSESELGKAVLMELSGQDVEASPVVAAEAGAEVSEKPGQEITVIPNNGPVVGQSTVGDQTPSEPQTSAERLTETKDGSSVEEVKAELVPEQEEAMLPVEESEAAGDGVETKVAQKATEKAPEDKFKIAANEETPERDEQMKEGEETEGSEEEDRENDKAEETPNESVLEKKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLHEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVSSGKEVSENMEAEAENQAESQTAEGTVESAATIKSTAC

Gene
NASP
Protein
Nuclear autoantigenic sperm protein
Organism
Oryctolagus cuniculus
Length
693 amino acids
Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Similarity
Belongs to the NASP family.
Mass
75.152 kDa
Fragment
single
Sequence
IYYTFDSFFCSPRMENGVLGNALEGVHVEEEEGEKTEEESLVENNDNVDEEAREELREQVYDAMGEKEESKKTEGMSLSKPETAKEQESEMEKGGREDMDISEPTEELPEKVALTPDQLTETSEEAEGAAAPEGLNEAEVTSGKSEQEAADAEKGKSVSGTDVQEEHKEQVEEKQGEVIVRIEKPTEASEEQPGTTLGKDNTAVEVEAEPVDATAKPVDVGGHEPKEQMATSGNEPGKAVLNQQLVGQDVPPVEESPMVTTEAAEVGSEVSEKSEQEATVVSNDGAVNGLSAAGDQASVDPQPSAERVTETKGGSELEEVRAELAPSQEAKLPIEESEGAGDGVETKVAQGVTEKSPEDKVKIAANEETQEREEQMKEGEETEGSEEEDKENDKAEEETPNDSVLENKSLPENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESQNYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEKRMAVLNEQMKEAEGSSTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVGSSTSGFTPSGGGSSVSTIASRKPADGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEAENQTESRAAMEGTVEAGATVESTAC