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NAA80

Gene
Naa80
Protein
N-alpha-acetyltransferase 80
Organism
Mus musculus
Length
314 amino acids
Function
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.
Similarity
Belongs to the acetyltransferase family.
Mass
34.583 kDa
Sequence
MELILSTSPAKLTLDPARQPELTLRFNLSKLTLDPARQPELSLSPRLAELTLDPTCHPEMSLSPGPAELTLDPQHQAKELPVPKLPELILEPVHCRPELMSACADLINDQWPRSRASRLHSLGQSSDAFPLCLMLLSPQPTPGAAPVVVGHARLSRVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLYFYAHLGYQLGEPVQGLAFTNRRLSTTVLRAFSKPPCPQPPCKEPILAAQAVPRSSKGPPLPPPPPLPQSLTASPPPSPEPLPQSPLETCYRDLKGCPIFWMEKDI

Gene
NAA80
Protein
N-alpha-acetyltransferase 80
Organism
Homo sapiens
Length
286 amino acids
Function
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992).
Similarity
Belongs to the acetyltransferase family.
Mass
31.445 kDa
Sequence
MELILSTSPAELTLDPACQPKLPLDSTCQPEMTFNPGPTELTLDPEHQPEETPAPSLAELTLEPVHRRPELLDACADLINDQWPRSRTSRLHSLGQSSDAFPLCLMLLSPHPTLEAAPVVVGHARLSRVLNQPQSLLVETVVVARALRGRGFGRRLMEGLEVFARARGFRKLHLTTHDQVHFYTHLGYQLGEPVQGLVFTSRRLPATLLNAFPTAPSPRPPRKAPNLTAQAAPRGPKGPPLPPPPPLPECLTISPPVPSGPPSKSLLETQYQNVRGRPIFWMEKDI