Protein
Norbelladine 4'-O-methyltransferase
Organism
Narcissus aff. pseudonarcissus MK-2014
Function
4'-O-methyltransferase converting norbelladine to 4'-O-methylnorbelladine. Involved in galanthamine biosynthesis. Can use norbelladine, N-methylnorbelladine and dopamine as substrate, but not caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde and tyramine.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
Sequence
MGASIDDYSLVHKNILHSEDLLKYILETSAYPREHEQLKGLREVTEKHEWSSALVPADEGLFLSMLLKLMNAKRTIEIGVYTGYSLLTTALALPEDGKITAIDVNKSYYEIGLPFIQKAGVEHKINFIESEALPVLDQMLEEMKEEDLYDYAFVDADKSNYANYHERLVKLVRIGGAILYDNTLWYGSVAYPEYPGLHPEEEVARLSFRNLNTFLAADPRVEISQVSIGDGVTICRRLY