Protein
Succinate-semialdehyde dehydrogenase (acetylating)
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Function
Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate. Participates in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family.
Sequence
MKAAVLHTYKEPLSIEDVNISQPKAGEVKIKVKATGLCHSDVNVFEGKTPVPPPVVAGHEISGIVEEVGPGVTRVKPGDRVISAFIHPCGKCGNCVAGKENLCETFSQVRLKGVMPDGTSRLSKDGKEIRTFLGGGFAEYAIVGENALTRVPEDMDLEKVAVLGCAGLTGYGAISSSKIEPGDTVAVIGVGGVGLSTIQLLRASGAGRIIAVGTKKWKLDRAMELGATDVVNSKEIDPVKAIKEITGGGPQVVIEAGGNEDTIHMALDSVRIGGKVVLVGLPPATAMIPIRVASIVRGGIEVVGNYGGRPRVDMPKLLELVRQGRYDPSRLVTGRFRLEEINEAVKMLEEGEAIRSLIIP