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Mjls_5435

Gene
Mjls_5435
Protein
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
Organism
Mycobacterium sp. (strain JLS)
Length
159 amino acids
Function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Similarity
Belongs to the class II aldolase/RraA-like family.
Mass
16.565 kDa
Sequence
MTIEPRATADLVDDIGPDVRSCDLQLRQFGGRPEFAGRVTTVRCFQDNALLKSVLSEPGDGGVLVIDGDGSLHTALVGDVIAALGRDNGWSGLIINGAVRDASTLRTLDIGIKALGTNPRKSTKTGAGERDVPVEFGGVTFTPGDVAYSDDDGIVIVTP