Protein
Bifunctional protein GlmU
Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Function
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate (By similarity).
Similarity
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
Sequence
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKIIDYFYGNEKIEFIVQEKQLGTGHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGLSKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNLINAGIYKLENFVFEILENLLPSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIENNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIKGSIIMKNTKIPHLSYVGDSIIGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGAVIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKESFVYKKDELIIKKRN