Myt1

Myelin transcription factor 1

1127 amino acids

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).

Belongs to the MYT1 family.

123.576 kDa

MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSYSSYQGIIATSLLNLGQIAEEALVKEDSVSVAKLSPTVVHQLQDEAAMGVNSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRSDDDKDEDSRSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQGHLGPGEPGKMAKPLDVVRKSCYSKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQLQTGDPPKNNSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGALNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEILSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVNTLTDMYSNQDCYQNPENKGLLETIKQAVRGIQV

myt1

Myelin transcription factor 1

1122 amino acids

Transcriptional activator which is essential for neuronal differentiation. Can promote ectotopic neuronal differentiation and confers insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors.

Belongs to the MYT1 family.

123.862 kDa

MNVDNVNKGTHTRSKASRVIPSDLIEQEVSLESCPLSRKRKLQESEQENPLSKRKSHPLKLALDEGFNVDSNGSEETEMKERDSGTEESEATLEEIEEDSEPTKPKEAPSPQTAEAESSDKVEPEETETKTESSPPAKATYSSYHEIIANSLLNLGQVAKEALVSEGHLKESELNNEKPTSVKSGQAEIEQLMVEEACEKEIIIQTEDAEEVIEVTSEPISESGTEPRDEVNCEDTEKLQKDMIDEEEEEEDDDVDEEDDDDLEEDEEEEEEHSSEMANQDLPHASQDSPKPHCEGHFSPKPEYSVIVEVRSDDDKDDDSHSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVKVVREPSRSSLDNMKNFSADEKQNRPIDTMRKSFYDAGRPEKRDIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLTRSHEKQQQPGDLSKSSSNSDRILRPMCFVKQLEIPQYGSYRPNMAPATPRANLAKELEKYSKVTFDYASFDAQVFGKRLLAPKIPSSETSPKAFKSKPFPKASSPCHSPSSSYIKSTSSSSSSGFDYTHDAEAAHMAATAILNLSTRCWEMPENLSTKQQDTPSKSSEIEVDENGTLDLSMNKHRKRESTFPSSSSCSSSPSMKSPDQSQRQNCTSATSSNMTSPHSSQTSRQDDWDGPIDYTKPNRQREEEPEEMEPAAASFASSEVDEQEMQEMQEMQEMQEESYEDRKYPGDVTLTNFKLKFLSKDSKKELLSCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKITPTKDDKDDPDLMKCPVPGCDGLGHISGKYASHRSASGCPLAARRQKEGALNGSAFSWKSLKTEGPSCPTPGCDGSGHANGSFLTHRSLSGCPRASFAGKKGKISGDELLGTNFKTSDVLENDEEIKQLNKEINELNESNSEMEADMVNLQSQITTMEKNLKNIEEENKVIEEQNEALFVELSGLSQALIRSLTNIRLPQMEPISEQNFDAYVNTLTDMYTNQECYQNPENKALLESIKQAVKGIKV

MYT1

Myelin transcription factor 1

1121 amino acids

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Belongs to the MYT1 family.

122.329 kDa

MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV

Myt1

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

533 amino acids

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins (PubMed:11882391, PubMed:12072468, PubMed:15581871). Mediates phosphorylation of Cdk1 predominantly on 'Thr-14' (PubMed:11882391). Also involved in Golgi fragmentation (PubMed:11882391). May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:11882391). May be a downstream target of Notch signaling pathway during eye development (PubMed:12072468).

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

61.131 kDa

MEKHHRLPLPELHDDKHRHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDFLSGEDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESPCSALSSAKVLDTSSFRRKKLFVLEYDDE