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MYRF

Gene
MYRF
Protein
Myelin regulatory factor
Organism
Homo sapiens
Length
1151 amino acids
Function
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).
Similarity
Belongs to the MRF family.
Mass
124.397 kDa
Sequence
MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASDLCFPDISAPASSASYSHGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRTITPETLCHVGVPSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAAMGQGLVPTDLHHTQQSQMLHQLLQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQGPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLRQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSLGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLASPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSKEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPATDYHFHFYRLCD

Gene
Myrf
Protein
Myelin regulatory factor
Organism
Mus musculus
Length
1138 amino acids
Function
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833).
Similarity
Belongs to the MRF family.
Mass
123.288 kDa
Sequence
MEVVDETEALQRFFEGHDISGALEPSNIDTSILEEYIGKEDASDLCFPEISAPASTASFPHGPPAIPGSSGLHHLSPPGSGPSPGRHGPLPPPTYGTPLNCNNNNGMGTAPKPFLGGSGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNDPHLLRTITPETLCHVGVSSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPVPPYAAMGPGLVPPELHHTQQTQVLHQLLQQHGAELPPHPSKKRKHSESPPNTLNAQMLNGMIKQEPGTVTALPPHPARAPSPPWPPQGPLSPGTGSLPLSIARAQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQLPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDVVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKLANKSSPAVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRSEEDLVDADGSLAVSTSCLLALLRPQDPGGSEAMCPWSSQSFGTTQLRQSSMTTGLPGTQPSLLLVTKSASGPALRALDLCSSQPCPIVCCSPPVSSPATDPALGPTLTPTPSPSSNPKHSGPGQMAPLPVTNIRAKSWGISANGISYSKHSKSLEPLASPVVPFPGGQSKTKNSPSFNLQSRARRGAPQPSPSPAQFTQTQGQLDPAPSLTSIQLLENSMPITSQYCVPEGACRLGNFTYHIPVSSSTPLHLSLTLQMNSSTPVSVVLCSLTSEEEPCEEGGFLQRFHPHQDTQGTSHQWPVTILSFREFTYHFRVTLLGQANCSSEAIVQPATDYYFHFYRLCD

Gene
myrf
Protein
Myelin regulatory factor
Organism
Xenopus laevis
Length
1092 amino acids
Function
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.
Similarity
Belongs to the MRF family.
Mass
120.78 kDa
Sequence
MDVEDENETLRRFFEGHDINGALEPSNIDTSILEDYISKEDSSEICFPDIPSSVSYASPQPCGSSGVHLSSVLSNVGHTGSINSGGVHHLGQQMAVRPGPGPTCGGPPYPPHLNCNNNNAMLNPKGYPMCMSNQGLPIKAEPKTSYAAGTLPDSPPDSGSEAYSPQQLSDPHLLRTMTPENICHITPPSRLEHPPPPHLQGPLPPHSIHQQHYPSMQRELYMKVESMMPQYQNLGPAMPPADLHHAQQSQMLHQLLQQQHGAELPVHPSKKRKHSDSPTNTLREQISNGGMVKSEPGLIQDNDSLNGSYLDPNYQSIKWQPHLQNKWVSLYDASYKELPMLTYKVDADKGFNFSTGDDSFVCQKKNHFQVTVYIGMIGEPKYVKTPEGILPIECFFLKLNGVKLEAINQAISIEQSQSDRSKRPFHPVTLSLPPDQVTKVTVGRLHFSETTSNNMRKKGKPNPDQRYFLLVVALQVQAQNQTYLVAAQASERIIVRASNPGQFESDSEVLWQRGQLPDTVFHHGRIGINTERPDEALVVHGNVKIMGSLMHPSDIRAKESVEEVDTTEQLKRISQMRLVHYHYKPEFASTVGLDENAAETGVIAQEVQEILPEAVKESGDLVCANGETIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSMKSTNSHTGSSQFSRAGSVPYKQRPPKVMGKTVPGPAHQSCVSQRFLQATIIALVIIMAFSVISMTTLYVLNLRSEDDMLGIDGSLTPPGSCTLTFFRQIHLTLPYALCTGSSQNFDTTQLKGNTTPPPKITKSPDWQQDPPLTINLCMDPPCEVVCCPHILSSESPTITRKTSAASAETISQTDPAPSTIIRKAKSRNLDKNRNSLQTLPRPVSPLPPYTQGKNKHSPNSLPVRDVRKRRSLEEESTPITPMDRTQGNSNDSRYSLTSLRLLETDALITNRSCSSMDTCGSGNYTYKLPISKYSPLSGSLSLELNSSSPVSVNFCETSKGKGCQEPAAVTSPRDQSCPQGTDVCVTQVSPTSHLWSLQLLPSQDFTFHLRVSPPGASGCDDLSIDPSQVTDYYFRFYRLCD