MVD2

Diphosphomevalonate decarboxylase 2

420 amino acids

Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (By similarity). Component of the triterpenes (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:24933610, PubMed:29378087). Promotes the accumulation of stigmasterol and beta-sitosterol (PubMed:24933610).

Belongs to the diphosphomevalonate decarboxylase family.

46.59 kDa

MAKELQKWVVMVTAQTPTNIAVIKYWGKRDETLILPINDSISVTLDPDHLCTTTTVSVSPSFEQDRMWLNGKEISLLGGRFQSCLREIRSRACDLEDEKKGIKIKKMDWEKLRLHIASYNNFPTAAGLASSAAGLACFVFALAKLMNLNEDNGQLSAIARRGSGSACRSLYGGFVKWIMGKEENGSDSIAFQLADEKHWDDLVIVIAVVSARQKETSSTTGMQDSCKTSMLIQHRAKEVVPKRIIQMEDAIEKRDFPSFARLACADSNQFHAVCLDTSPPIFYMNDTSHKIISCVEKWNRSVGTPQVAYTFDAGPNAVLIARDRKIAALLLRRLLFHFPPTFQHCLNSYVIGDKSILQDVGVQDMKDIESLPPPPEIKDNIPAQKSNGDVSYFICTRPGRGPVLLPDSGALLNPETGLPK

MVD2

Diphosphomevalonate decarboxylase MVD2, peroxisomal

419 amino acids

Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP.

Belongs to the diphosphomevalonate decarboxylase family.

46.248 kDa

MATEKWVFMVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSRYQNCLREIRGRAGDVEDMEKGIKIRKKDWEKLNLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNVDEDPSHLSAIARQGSGSACRSLFGGFVKWTMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPKRILQMEEAIKNRDFASFTQLTCTDSNQFHAVCLDTSPPIFYMNDTSHRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIARNRKVAVQLLQGLLYYFPPKSDTDMKSYVVGDNSILKEAGLDGASGVENLQPPPEIKDNIGSQDQKGEVSYFICTRPGKGPIVLHDQTQALLDPETGLPK