Protein
Multivesicular body subunit 12A
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity).
Similarity
Belongs to the MVB12 family.
Sequence
MDPGPGANGMPLAGLAWSSASAPPPRGFSAISCTVEGTPASFGKTFAQKSGYFLCLNPLGSLENPQENVVVDIQILVDKSPLPPGFSPVCDPLDSKASVSKKKRMCVKLVPLGAADTAVFDIRLSGKTKTVPGYLRVGDMGGFAIWCRKAKAPRPVPKPRALSRDVRDLSLDSPGQPSKGGFPERTLSRLGSRASTLRRNDSIYEASNLYGISAMDGVPFTLHPRFEGKSCGPLAFSAFADLTIKSLADIEAEYNYGFVVEKTAAARLPPSVS