MUC20

Mucin-20

709 amino acids

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

71.982 kDa

MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG

Muc20

Mucin-20

656 amino acids

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity).

68.72 kDa

MGSVWGLAVPLLVFCWKVGVSVSSPGLDISRSVPLVTTNNMEVSTFTQRDRPSSERAFQTTNLIQYVPLDTQTLSTESASNALSATSISSEVNSRDTQTTSFVTKTRKTHTTTPAASSLEAQTTSPNLSTLNIQITSPIASSLDAQTIFPVSLSLSTQTTSPAPSFLDTQTTSPEPSSLTTSPAPSSLITSPTPSSLTTSPAPSFLDTQTTSPAPSSLTTSPAPSSLDTQTISPIELTLKTQTISTVTETRTVSIRIPSDLTVMHTIPTETLAPSNSPRTGMSTVQTGTVWDSIEAVFDTLCTDDSSEEARKITVDLLTLAHTSTEVEYLSSESSSSSDSSAGVLSSSRVLGPDSATPAKGLVAFNITHIKLSNCITEIETTITISGAPGASLSPTEATAALFTSEILTLPPPTEAKPIFPETTSLSGILSTAGTPALATTLEGTVSTSAITESETAVAQTLTSVGTSVTVRRNPLENTSTLSIETQSHTEVLGTITVPMVAGSTMGEAASFVSFTALDSSSLSVVVTTESSATSETLTTGNTTNSSFLTESHPPFSIYSTTASTSKNPNITLTKTTASPKPPTHPTTSASTAWIRKTTKHDPGEDGGFLLVRLTVASPKDLTEHNAREKLMNQLRRELHARMPLVHMSFLSIRRG