MTMR8

Myotubularin-related protein 8

704 amino acids

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

78.919 kDa

MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ

mtmr8

Myotubularin-related protein 8

632 amino acids

Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

72.503 kDa

MEHIITPKVENVKLLNRYTEKKSALGTLYLTATHLIYVEQTSNTRKETWVLHHHILSVEKLLLTASGCPLLIRCKTFQHLHLLFQKERDCQDVYQSLLRLFQPVKEEELYAFLYNPHQNEEERRRGWELISVVNDFNRMGLSNDYWEISHINKNFEMCSTYPSILGLPKSASVATVTGSAKFRSRGRLPVLSYYHKDTKAAICRCSQPLSGLNSRCVEDEQMLQAISQANPNSPFIYVVDTRPKLNAMANRAAGKGYENEDNYSNIRFQFQGIENIHVMRSSLQKLLEVCSMKSPSMSDYLTGLENSGWLRHIKSVMDAGVFLAKAVCEERASVLVHCSDGWDRTAQVCSLACLLLDPYYRTIKGLMVLIEKEWISFGHKFSHRCGHLDSDPKEASPVFTQFLECVWQLSQQFPCVFEFNEHYLIEIHDQVYACQYGNFIGNCQKERLDMRLHEKTFSLWPHLLENQHQYRNPLYRRSLESTVLRPSTLPLHFKFWCGMYNHYDRGMHPKQSVLDTLLTLTQRQVEGERTMTELQRQLAVADGVLPDPAGPINTHADQNNQSEKMPAPPVVQSNGSCAPLINGNVKEVGPGAENSNQEDREEPAANEHDLSSKDKPVFVETEHSKEEVQESS

MTMR8

Myotubularin-related protein 8

629 amino acids

Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

71.967 kDa

MEHITTPKVENVKLLDRYTNRKAASGTLYLTATHLIYVDASAEVRKETWILHHHIATVEKLPLTTAGCPLLIHCKNFHVAHFVIGQERDCHEVYTSLLKLSQPVKPEELYAFSYNPKMSKDNREIGWKLIDLKVDYQRMGIPNDYWEITDLNKDYEVCNTYPPEIVVPRAASKATVIGSSRFRSRGRIPVLSYLYKENNAAICRCSQPLSGFSARCLEDEQMLQAIREANPGSPFMYVVDTRPKLNAMANRAAGKGYENEDNYDNIRFKFIGIENIHVMRSSLQKLLEVCETKSPSMSDFLTGLENSGWLRHIKAVMDASVFLAKAVKDEKASVLVHCSDGWDRTAQVCSLASLLLDPFYRAFKGFMVLIEKEWIAMGHKFSHRCGHLDGDPKEVSPVFTQFIECVWQLMQQFPCTFEFNEHFLLEIHDHVYSCQFGNFLGTCHKEREDLKIFEKTHSLWPFLLQKKQELRNPLYRGFTAYKELQPNTLPFSFQFWCGMYNRFDKGMHPKQCVLDHLLSCMNQKIKLEDNASELENKLPFLDGPLPNEACFLSKVGCAASKTPMLNTPQDYEGEAPPVLTNGISVGDINVTSDVDQRNKENLANHRDLHLNDSVDVLNSEAKDGKPQHH