Protein
Probable inosine/xanthosine triphosphatase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the YjjX NTPase family.
Sequence
MDSVVFYMKVNVGSGNPVKVRATENVLGLIYGNVEVRGVEVESGVPDQPVGLEETVRGAVNRARRAFRDCELSVGIESGLHRVPETITGFVDLQWCAIYDGEHITLGVSAGFEYPPMVVEEVLAGREVGDVMDELTGVDELGRKRGAVSFLSGGLLDRTGNTEQCVLMAMIPRMNPSLYGLK