Protein
Probable N-glycosylase/DNA lyase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion (By similarity).
Similarity
Belongs to the type-1 OGG1 family.
Sequence
MRIPVGDFDLEMTQRSGQTSQPPWREVEGAFRELLIIEGVPCPVEVRNEAGVLRVRPYVDVPQKTLREKIEYIFDLKFDIEDFYTFLEDKNLSYTLDSSRGLRLFLAKDPFECVISSIASANCSVVRWTRSIEDIRRLWGQANTFNGETFHTFPSPHVLTGVAEGSLEDLQRAEDNLPSDFSFNDLRSCGVGYRAPYIRETSRILAEEMDIRRIDGMDYDDARELLLELSGVGPKVADCILLYGFRKTEAFPVDVWIRRIMNHIHPGRNFNDRSMVEFARREYGEMADYVQLYLFNHARRSGLLDRLRQGTG