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MTHFS

Gene
MTHFS
Protein
5-formyltetrahydrofolate cyclo-ligase
Organism
Homo sapiens
Length
203 amino acids
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Similarity
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Mass
23.256 kDa
Sequence
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Gene
Mthfs
Protein
5-formyltetrahydrofolate cyclo-ligase
Organism
Mus musculus
Length
203 amino acids
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).
Similarity
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Mass
23.202 kDa
Sequence
MAAVTVNSAKRGLRAELKQRLRALSAEERLRQSLLLTQKVIAHNQYQNSKRISIFLSMQDEVETEVIIKDIFKQGKICFIPRYQFQSNHMDMVRLTSSEEIALLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRCVQHQEVKPYTMALAFKEQICPQIPVDEHDMKVDEVLYEDSPAS

Gene
MTHFS
Protein
5-formyltetrahydrofolate cyclo-ligase
Organism
Oryctolagus cuniculus
Length
201 amino acids
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate. It can also use 5-formyltetrahydropteroic acid (5-CHO-H(4)Pte) and 5-formyltetrahydropteroylhistidine (5-CHO-H(4)PteHis) as substrate.
Similarity
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Mass
22.733 kDa
Sequence
AAAAAVSGAKRSLRAELKQRLRAISAEERLRCQRLLTQKVIAHRQYQKSQRISIFLSMPDEIETEEIIKDIFQQGKVCFIPRYRLQSNHMDMVKLASADEISSLPKTSWNIHQPSESDTREEALATGGLDLIFMPGLGFDRNGNRLGRGRGYYDTYLQRCLQQQGAKPYTIALAFREQICPQVPVDDTDVSVDEVLYVDAA