Protein
Geranylgeranylglyceryl phosphate synthase
Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
Function
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use sn-glycerol-3-phosphate (G3P) or dihydroxyacetonephosphate (DHAP) as substrate.
Similarity
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
Sequence
MKVEDYFHDILGERKIHLTLIDPEEQTPEEAVEIAEAAIRGGTDGIMLGGSTTDSSELDATAGALRENIDVPIILFPGNTTGVSRHADAIFFMSLLNSNNPYWIIGAQALGAPAVKKMGIEALPMGYLVVEPGGTVGWVGDTKPVPRNKPDIAAAYAMAAEFLGMRLFYLEAGSGAPQHVPEEMISLVKRCTDQILIVGGGIRTGADAARVAGAGADIIVTGTVVENSSNVEDKIREIVEGMGSL