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MRTFA

Gene
Mrtfa
Protein
Myocardin-related transcription factor A
Organism
Mus musculus
Length
964 amino acids
Function
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381).
Mass
102.546 kDa
Sequence
MTLLEPEMLMMAVQSVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERAELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLESRVSDPLPSATSISPTQVLSQLPMAPDPGETLFLAEQPPLPPAPLLPPSLANGSIVPTAKPAPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAILPAPPKPSAETPGSSAPTPSRSLSTSSSPSSGTPGPSGLARQSSTALAAKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESGFSSCQLSCQPQGSAHAFGSGLVVPTTNHGDTQAPAPESPPVVVKQEAGPPEPDLAPSSQLLLGSQGTSFLKRVSPPTLVTDSTGTHLILTVTNKSADGPGLPAGSPQQPLSQPGSPAPGPPAQMDLEHPPQPPFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAAAAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDFLESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSGMGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTAAPSLFSMDFLDGHDLQLHWDSCL

Gene
mrtfa
Protein
Myocardin-related transcription factor A
Organism
Xenopus laevis
Length
936 amino acids
Function
Transcription coactivator that associates with the serum response factor (srf) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The srf-mrtfa complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Mrtfa binds G-actin via its RPEL repeats, regulating activity of the mrtfa-srf complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
Mass
103.238 kDa
Sequence
MTLLDTEQALLAIHTVLQLKLQQRRTREELENQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERAELVRMHILEETSAEPSLQAKQIKLKRARLADDLNEKISQRPGPMELVVKNILPVETSLKEVIIDVDYPEVVDNSSFDEDSSDALSPEQPASQESQGSIPSPIENRPSETTQIPALSPSHAFSCVQFGTDAFNQDSLQSTAITISNGLTASICKSLPALVKQSQPKPSFEKSQRIKKPKEPKPKVKKLKYHQYIPPDQKQKGTPAMDSSYAKLLQQQQLFLQLQIINQQQHQHYNYQTILPAPPKPLPDQQNTNSSSTTTVRSMSTVAPSTLATPTITRQNSNVAVGGRTGPLPHNLDEMKVAELKLELKHRGLPVSGTKIDLIERLKASQDPSTATAASAKPTPVQQAKPPEVVPIVSSSCLTTREPIKLCSTSSTPPGSPCPSEVSVVSMDEVSMISDALGETVACPVTQQVQQNPAAEKSPPDARDKDLMLREKDRQIEELTQRLKQKQELVERLRQQLEQEKRTPQHSTDDQQALILAVKQEPLPLTVDSINKKASSIVKQELNTAIICQQEPQLLIGPVSSGIEGKVDNSAGTKLVFTLTNPSSQLPEENRQIVLQKVPTPPSSLHPNNSLPKQEVLLSCCALQNQKPALQLVPGTVLSLSSSNLQPMLNMNGFQKWHGEALDSLQKQLVHNESPATPPQQPEPEPPPHSIFLTHSSPQWSKNPPGYDEAMKQQPNSCEDGRPGCLQAVDFFDVLIKNLDIPSEFKDYLVPCLKQTSPSHQAAQMVPQVEMAPPPSPIHSALGRLEDFLESSTGTPLLRGHQDGPSSMPLIDDLHSQMLSSLAILDHPPSPMDTSDLHFSPIGNSLGLDISEPPLDGMDWLELSEPPAMNLTPLSTFTPSVFSTDFLDSHDLHLHWDSCL

Gene
MRTFA
Protein
Myocardin-related transcription factor A
Organism
Homo sapiens
Length
931 amino acids
Function
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
Mass
98.919 kDa
Sequence
MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL