Mov10

Putative helicase MOV-10

1004 amino acids

Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (By similarity). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (PubMed:28662698). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity).

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

113.583 kDa

MPSKFSCRKLRETGQRFESFLAERGLDLETDRERLRTIYNHDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSNISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIHLDLNRKEVLTLRLRNGGSKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHIYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGERPDRAKGYELELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVTYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPEWRNEL

MOV10

Putative helicase MOV-10

1003 amino acids

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity).

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

113.885 kDa

MPSKFSCRQLRETGQRFENFLVDRGQDRETDRERLRTIYNQDFKTSFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFGLDRWADVWFPEKRRMKPGLEMSKHHRSLLATIFHDRAEYMHGKHGVNVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQPVTLTHLFPFCRTPQFSFCNGDRELPCLLGPGECYELHVHCKTSFVGYFPATVLWELLGPGEPGSEGAGTFYIARFLAAVAHSPLAAQLKPTTPFKRTQVSRNPVVTRRIEEGERPDRAKNYDLEFSLPLGTYYPPPRLRQLLPVLLRGTSIFTAPKEIAEIKAQLQTTLKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPIDRNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETHHEDPVTYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWPLEPMLFPVASRGVPLLPSDVKLKLYDRSLESNPEQLQAMKHIVMGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIHLVPEDIKPCCNWDAKKGDFVFPSKKKLQEYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHAMEPESLVAIAGLMEVKEADNPGGQLVLAGDPRQLGPVLRCPLTQKHGLGYSLLERLLTFNALYKKGPDGYNPQFITKLLRNYRSHPTILDVPNRLYYDGELQACADVVDRERFCRWEGLPRQDFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDKQLRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGLKSHDYLPQEREGEEGLSLQVEPEWRNEL

MOV10

Helicase MOV-10

1003 amino acids

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

113.671 kDa

MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL

MOV10

Putative helicase MOV-10

967 amino acids

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity).

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

109.051 kDa

MPRFSVAEARRYGDQFVQFLRDPSREQESRREVLRDIYSQEFRTRTDIRTPSFSSILYALRVSHQAQVHGQTVHFKKARRRVVVADQYRRPRTDTEVSAPAPGQQPSSGPPAPQSRAKKWAEFIRGKHGVEIVSEYDQANGQIRFPVALDKTKTFTVQVQNHGAEAVTLHRCRPLRRLQELSFLDEQGVTQGQALVLHPGGAYPIQVRCLTSHNGFFRAVVMFEFSKEPDGSFSIGRSIAAIAQSPLARELGPSAPYRPYQASLQRPITVVTEDGVPPVSSLKNELEKEIPLGTYPYPKSLKETIMLGPKTSPDSSWMKMQSLLEAPLQPENYKQKFELLLHLEEIQLEVDIRRYDLQEVPMVQNRALLLLNVPGVAENRPSVLRGDHLFASLSSERDSSPRVLYKGYVHGVELERVQLGFSPKLMKKFVNDLKFDVTFTFNRLPLQVQHRAAAMAMQKGLDSVLFPSASCQRSLFTGIFQPRWFDRKVEANEEQCQAVKHIVTGMSRPAPYLIFGPPGTGKTVTLVEAIKQVWSCFKDARILACAPSNSAADLLCQRLLTNIAPRYIYRIMASSANYKDVPADVRPCCNWDDSEKCYVYPSKKLLKPYRILITTLVTAGRLVSANFPPGYFSHVFIDECGHAVEPESVVAIAGLLTTMDPDTNPNGGQLVLAGDPQQLGPVPRSPLAAQHGLGTSLLERLMLHNALYAKSDEGYNPQFVTKLLWNYRSHKAILKVPNELFYDSELKAYEGSEPDVRNFYCTWEELPNRGVPIIFHGVCGEDEREAKSPSFFNTAEIEVVVQYLQKLLQSQGRRGCPTISPKEIGIISPYRKQVEKIRLAITSKDPVLRALPDIGQLKVGSVEEFQGQERRVILISTVRSCSEYLQLDQTFRLGFLKNPKRLNVALTRAKALLIVVGNAAVLSKDPHWHRFLRYCRDEGAYRGYPYEEEPPEEDSLANHLDSLHLGN