About Products Protein Database Contact

MORC2

Gene
MORC2
Protein
ATPase MORC2
Organism
Homo sapiens
Length
1032 amino acids
Function
Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AFX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864).
Mass
117.823 kDa
Sequence
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD

Gene
MORC2
Protein
Protein MICRORCHIDIA 2
Organism
Arabidopsis thaliana
Length
626 amino acids
Function
Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV) (PubMed:19704828). Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation (PubMed:20332379). Required for pathogen-associated molecular pattern (PAMP)-triggered immunity, basal resistance, non-host resistance and systemic acquired resistance (SAR) (PubMed:23250427). Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing (PubMed:24799676). Exhibits ATPase activity (By similarity).
Similarity
Belongs to the MORC ATPase protein family.
Mass
69.977 kDa
Sequence
MPPMAKNAAVTDVVHLDSDSDSDNGVVGGRESASTIAGAATMAPRETLECRSFWKAGDYFVIPNVVTPTAPGMLEHARVHPRFLHSNATSHKWAFGAIAELLDNAVDEIQNGATFVKIDKINIVKDNSPALVFQDDGGGMDPAGLRKCMSLGYSSKKSNTTIGQYGNGFKTSTMRLGADAIVFSRSTRGGTSTQSVGILSYTFLRKTGQDDVTVPMIDIDISKERPQPIIYGSPEDWAANLEILLKWSPFSTEDELLQQFEDVGTHGTKVIIYNLWLNDEGIYELSFDDDEEDIRLRDESVNDGKRLHHKILELRSHISYHLRYSLRAYASMLYLKKFKNFKIIIRGIPVEQFNIADGFRFPEIIKYKPHTATTEQASTEIKIGFVKEAPKLAICGFNVYHKNRLIRPFWKVTMGGDSTGHGVVGVLEANFIEPAHDKQDFERSSLFQRLEARLKKIVYSYWYSHCHLLGYHKYQMPADKSKKIAIPDQPPTISTVNPSPLPSDKISQGGPIIREINLSNATSSRTVAFASPHLRNSTGLRSNFQPVQLNPQPTAADTGNNLDGKSAGEIRQENLQLFMRCEEYIKKENETEQTVKSLEKELEEFKSKCAHLALLVDAKKKEMQQA