Protein
Alpha-1,2-mannosyltransferase MNN23
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Similarity
Belongs to the MNN1/MNT family.
Sequence
MSINFLSIPRNRFKAIGVLSVTCILIYVILHSSIITTDFDVSDYGDKFIPSIIFDDNNDNGENLKDPQPELDNDKGNGETDTTTSNSMTTAHTFWKGIFDTFDKYKMDLGQDPENAVSYVDKLKQKQGPLNKEVLLSKAIVSSELMKHLKEKHSGVVEDLPSVMPGSVYNKGSKGVVIIGGGKFSWLAYLALVQLRNVGSKLPVEIVMPSRADYEKELEFCENTLPEMQASCVVLPDVLGEAVMKNRKFASYQFKALALVVTSFEHILLLDSDNMIVSNPDEIFESKLYHQYGMITWPDYWKRTISPLFYDVAEIEVNENKRVRYNRFPLYNAPNVRSNIYTDQEREEVPFHDLQGSIAELSTESGQLIINKHTHGKTILLALYYNFYGPNLFYKLFSLGEQGEGDKDTFVAAAVVTRQDYYQVKSFIKTFGYADSDDKFQGVSMGQRNPLIDRKHYEDHVLALLEKDSFKSSSIADQIEQMKKFENEDFDQHNSIPLFTVHCNYPKLDPKLYMSRDDLYDEKEKKLKYRLYGNLKYTKEVVKDGETGTEASTDKVQIDFELQQWQHMQDILCLKKIYFTHFIDNDMNELCQFIENQVAWLSKSQN