Protein
Protein MMS22-like
Function
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity).
Similarity
Belongs to the MMS22 family. MMS22L subfamily.
Sequence
MDNCPPASTFLTDSLELELQTEWCNPPCFSCDFDNRGGGKHFSGESYLSSGALKRVILNLDPLPTNFEEDTVEIFGIEWVTETALVNSSRVLFHLFRQQLYNLETLLQASCDFGKISTLHCKAHNIRQLCVTFLHYVKVFIFRSLQVRNAESHVPVHPYETLEAQLPSVLVDELHGLLLYIGHLSELPTTNTGAFVNQNQTKLYPPSWHLLHLHLDIHWLVLEILHMLGEKLKQVVYSHQFMNLAGDNLTNVSLFEEHCENLLCDLINLSLNRYDKKVRPSEALMSHHCPCPCIKELWVLLIHLLNHRSKWSLSESFWNWLNKLLKTLLEKSNDQRRSVLIVQPRDPLGFSWWIITHVASFYQFDRHGTPDEMRQMESNWNFVEELLKKSISVQDGILEEQLRMYLHCCLTLCDFWEPNIAIVTILWEYYSKNLNSSFSISWLPLKGLTYIIKSPLSMLEMVKTCCCDKQDHDLYKSSSSYTIFLCILAKVVKKAMKNNGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEVEDVASHVLRLLDFLKPTFKTSPLIWKGQMAFLLMYTQKNLDIGVLAEKFSNAFREKAKEFLVSKNDEMGQRQTLWTLLSIYMDSVQEVFETSRCLHPSHEKLLNDGFSMLLRACQESELRTVLNFLQAVLARIRSLHQQLRQELQREHGDLSVQSSLSTKERHLAAVASALWRHFFSFLKSQRMSQIVPLSQLADAAADFTLLAMDLPSTAPSDLQPQPVTSMIQLFGWDDIIWPQVVARYLSHFLQNSMLCEALSHSGCVSFQALTVRSWIRCILQMYVKNLHVPDDSFIDINPEQAVEKDYMEQLTELTRLLFKLSEVKNIFSKSQVELPIPDDPKKALIRFFEAVGITYGNLQTVSDKSAMVTKSLEYLGEILKYIKPYLGKKVSSAGLQLTYTMMGTLVKSWALIFATSKAQKLLFRIIDCLLLPHTVLQQEKELPAPMLTAIQKSLPLYLQGMCIVCCQSQNTNAYLNQLLGNVIEQYIGRFLPASAHVLGLGQHPVLLALKNSASVPPMSLLKKCIVHVIRKSYFEFKGSLLPPRLASILAFILQLVKETNTDVSEIELLLPGVLKCLLLVSEPQVKRLATENLQCMVRACQVGSGGEPAAQLTSVFRQFIEDYGMRYDYQIYSILEAVAALDQQVVIHLVPTLTQSLKNSERKWGLGRNSAQREAYSKLLSQLGQVGQDEIQRLENDHIESML