MMS19

MMS19 nucleotide excision repair protein homolog

1134 amino acids

May select specific target apoproteins to which a Fe-S cluster produced by the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway is transferred.

Belongs to the MET18/MMS19 family.

124.255 kDa

MMVEPNQLVQHLETFVDTNRSSSQQDDSLKAIASSLENDSLSITQLVREMEMYLTTTDNLVRARGILLLAEILDCLKAKPLNDTIVHTLVGFFSEKLADWRAMCGALVGCLALLKRKDVAGVVTDIDVQAMAKSMIQNVQVQALALHERKLAFELLECLLQQHSEAILTMGDLLVYAMCEAIDGEKDPQCLMIVFHLVELLAPLFPSPSGPLASDASDLFEVIGCYFPLHFTHTKDDEANIRREDLSRGLLLAISSTPFFEPYAIPLLLEKLSSSLPVAKVDSLKCLKDCALKYGVDRMKKHYGALWSALKDTFYSSTGTHLSFAIESLTSPGFEMNEIHRDAVSLLQRLVKQDISFLGFVVDDTRINTVFDTIYRYPQYKEMPDPSKLEVLVISQILSVSAKASVQSCNIIFEAIFFRLMNTLGIVEKTSTGDVVQNGNSTVSTRLYHGGLHLCIELLAASKDLILGFEECSPTSGCANSGCSMVKSFSVPLIQVFTSAVCRSNDDSVVDVYLGVKGLLTMGMFRGGSSPVSRTEFENILVTLTSIITAKSGKTVVWELALKALVCIGSFIDRYHESDKAMSYMSIVVDNLVSLACSSHCGLPYQMILEATSEVCSTGPKYVEKMVQGLEEAFCSSLSDFYVNGNFESIDNCSQLLKCLTNKLLPRVAEIDGLEQLLVHFAISMWKQIEFCGVFSCDFNGREFVEAAMTTMRQVVGIALVDSQNSIIQKAYSVVSSCTLPAMESIPLTFVALEGLQRDLSSRDELILSLFASVIIAASPSASIPDAKSLIHLLLVTLLKGYIPAAQALGSMVNKLGSGSGGTNTSRDCSLEEACAIIFHADFASGKKISSNGSAKIIVGSETTMSKICLGYCGSLDLQTRAITGLAWIGKGLLMRGNERVNEIALVLVECLKSNNCSGHALHPSAMKHAADAFSIIMSDSEVCLNRKFHAVIRPLYKQRCFSTIVPILESLIMNSQTSLSRTMLHVALAHVISNVPVTVILDNTKKLQPLILEGLSVLSLDSVEKETLFSLLLVLSGTLTDTKGQQSASDNAHIIIECLIKLTSYPHLMVVRETSIQCLVALLELPHRRIYPFRREVLQAIEKSLDDPKRKVREEAIRCRQAWASITSGSNIF

MMS19

MMS19 nucleotide excision repair protein homolog

1134 amino acids

May select specific target apoproteins to which a Fe-S cluster produced by the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway is transferred.

Belongs to the MET18/MMS19 family.

124.255 kDa

MMVEPNQLVQHLETFVDTNRSSSQQDDSLKAIASSLENDSLSITQLVREMEMYLTTTDNLVRARGILLLAEILDCLKAKPLNDTIVHTLVGFFSEKLADWRAMCGALVGCLALLKRKDVAGVVTDIDVQAMAKSMIQNVQVQALALHERKLAFELLECLLQQHSEAILTMGDLLVYAMCEAIDGEKDPQCLMIVFHLVELLAPLFPSPSGPLASDASDLFEVIGCYFPLHFTHTKDDEANIRREDLSRGLLLAISSTPFFEPYAIPLLLEKLSSSLPVAKVDSLKCLKDCALKYGVDRMKKHYGALWSALKDTFYSSTGTHLSFAIESLTSPGFEMNEIHRDAVSLLQRLVKQDISFLGFVVDDTRINTVFDTIYRYPQYKEMPDPSKLEVLVISQILSVSAKASVQSCNIIFEAIFFRLMNTLGIVEKTSTGDVVQNGNSTVSTRLYHGGLHLCIELLAASKDLILGFEECSPTSGCANSGCSMVKSFSVPLIQVFTSAVCRSNDDSVVDVYLGVKGLLTMGMFRGGSSPVSRTEFENILVTLTSIITAKSGKTVVWELALKALVCIGSFIDRYHESDKAMSYMSIVVDNLVSLACSSHCGLPYQMILEATSEVCSTGPKYVEKMVQGLEEAFCSSLSDFYVNGNFESIDNCSQLLKCLTNKLLPRVAEIDGLEQLLVHFAISMWKQIEFCGVFSCDFNGREFVEAAMTTMRQVVGIALVDSQNSIIQKAYSVVSSCTLPAMESIPLTFVALEGLQRDLSSRDELILSLFASVIIAASPSASIPDAKSLIHLLLVTLLKGYIPAAQALGSMVNKLGSGSGGTNTSRDCSLEEACAIIFHADFASGKKISSNGSAKIIVGSETTMSKICLGYCGSLDLQTRAITGLAWIGKGLLMRGNERVNEIALVLVECLKSNNCSGHALHPSAMKHAADAFSIIMSDSEVCLNRKFHAVIRPLYKQRCFSTIVPILESLIMNSQTSLSRTMLHVALAHVISNVPVTVILDNTKKLQPLILEGLSVLSLDSVEKETLFSLLLVLSGTLTDTKGQQSASDNAHIIIECLIKLTSYPHLMVVRETSIQCLVALLELPHRRIYPFRREVLQAIEKSLDDPKRKVREEAIRCRQAWASITSGSNIF

mms19

MMS19 nucleotide excision repair protein homolog

1115 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

127.373 kDa

MTSNITELNKWIEGYVNPQSEESVKTNAINMVLLYMKSNKIDLQDVVQGLGDYLKSNDSILRARGTLLLSEVLCRLPDLPLNQDQVHFLAMFYCDRLQDYACSSEVVKGITGLITNHTPDYPDNQKLLRNIFSEVHPTSLTQAHRKMVLQVIDIMFNKCLSEIQELKNDFMVGYLQFIDNEKDPRNLIFSFKLLPKVIYNIPEHKHFLESLFEIISCYFPISFNPKGNDPNSITKDDLSNSLLNCFSCTPLLAEHSIPFLIDKICSNLIETKIEALQTLVYCCDRYGGFAVQPFLEEIWSTLRTLILTHKNTTVIEESKKTIFYLTRSFTKERKVLESFLSIMIKECLHHIKSSQDSKIAIYCASILYQSVSASLLSSKIILIHIFPNLFNFLSELQKQDTVQKVNEQNSVIALFNDLLKANSIAFEMYSNENKEPNPLEPFVDQLFKLFSDLLLLNSSSSIRSNSIECLSNLYISKKVHTTEQDDDDSEQITNEFLLDLEKRQFIIKSLVSLLNSSDNTLRHKSLDSLFTIASNEDPSVLNLYVIPTLLQMINHSSCNINTTNNKINNNNNNNNIVIKNNKCQDEHCNEDHSNKNENNNNSNENSNGNSTSGSDDDLKHYLEAFTKLCTHQPLLESVIPQIQVLLQHNIKETYQSNEDFEKSILILQSISFILEKSTNIKSMTICSKSILFPLIKGLYKQELISSSNDNNNNNNNNSNRFNQILTPTLKMIHSIFENISIESQKPLLEKLIKLFLNGDTLVINYQLPTTTTTIIKPFEKSSPYKYLIPIFTTIISQSKLDLSENNELKQSLYQMSLDVNVDDSIAISCSKAYSSIINKQQQQQQQDQINFNFFNDNLLKVINDTTTPLPLKIRHLDLFTWCTKALLTNGNSINIKLGSCLADIISNENVELSYHASKSFGILLSETDVLNEKSGSIIKILFEQKFFTLMFPILLESFKVSKNKELQTISSHYLIAISNLLKHVPKEILLAELNEILPIVMQSLKSSDNNDQVQLLDSSLQTLTMLINETPSSFISYLDSLIPSLIKISTKSTKYNLKRSALEILTLLSKSIPFVNLFPYKTQVVTDIIPCLDDKKRIVRREAQKCRNSWYILQK

mms19

MMS19 nucleotide excision repair protein homolog

1115 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

127.373 kDa

MTSNITELNKWIEGYVNPQSEESVKTNAINMVLLYMKSNKIDLQDVVQGLGDYLKSNDSILRARGTLLLSEVLCRLPDLPLNQDQVHFLAMFYCDRLQDYACSSEVVKGITGLITNHTPDYPDNQKLLRNIFSEVHPTSLTQAHRKMVLQVIDIMFNKCLSEIQELKNDFMVGYLQFIDNEKDPRNLIFSFKLLPKVIYNIPEHKHFLESLFEIISCYFPISFNPKGNDPNSITKDDLSNSLLNCFSCTPLLAEHSIPFLIDKICSNLIETKIEALQTLVYCCDRYGGFAVQPFLEEIWSTLRTLILTHKNTTVIEESKKTIFYLTRSFTKERKVLESFLSIMIKECLHHIKSSQDSKIAIYCASILYQSVSASLLSSKIILIHIFPNLFNFLSELQKQDTVQKVNEQNSVIALFNDLLKANSIAFEMYSNENKEPNPLEPFVDQLFKLFSDLLLLNSSSSIRSNSIECLSNLYISKKVHTTEQDDDDSEQITNEFLLDLEKRQFIIKSLVSLLNSSDNTLRHKSLDSLFTIASNEDPSVLNLYVIPTLLQMINHSSCNINTTNNKINNNNNNNNIVIKNNKCQDEHCNEDHSNKNENNNNSNENSNGNSTSGSDDDLKHYLEAFTKLCTHQPLLESVIPQIQVLLQHNIKETYQSNEDFEKSILILQSISFILEKSTNIKSMTICSKSILFPLIKGLYKQELISSSNDNNNNNNNNSNRFNQILTPTLKMIHSIFENISIESQKPLLEKLIKLFLNGDTLVINYQLPTTTTTIIKPFEKSSPYKYLIPIFTTIISQSKLDLSENNELKQSLYQMSLDVNVDDSIAISCSKAYSSIINKQQQQQQQDQINFNFFNDNLLKVINDTTTPLPLKIRHLDLFTWCTKALLTNGNSINIKLGSCLADIISNENVELSYHASKSFGILLSETDVLNEKSGSIIKILFEQKFFTLMFPILLESFKVSKNKELQTISSHYLIAISNLLKHVPKEILLAELNEILPIVMQSLKSSDNNDQVQLLDSSLQTLTMLINETPSSFISYLDSLIPSLIKISTKSTKYNLKRSALEILTLLSKSIPFVNLFPYKTQVVTDIIPCLDDKKRIVRREAQKCRNSWYILQK

mms19

MMS19 nucleotide excision repair protein homolog

1043 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.55 kDa

MAADNNVLLGLVEEFVSGQVDSKAADTSTGVKNGQFTVLQLVEALGVSLTSSQPQTRGRGVQLLSQVLQECYSGLSEREVEVLIAFYENRLKDHYVITPHVLRGLKALAKCSVLPPGSAVSILKSIFQDVHVQQQSLMVTERSCVYNILISLMESREEELKGLGADFIFGFVQSVDGERDPRNLLLAFQVAKNIIYRGYDLGKFVEELFEVTSCYFPIDFSPPPNDPHGITQEELILSLRAVLTGTPRFAEFLLPLIIEKMDSDVQSAKVDSMHTLAACGQTYSHKELAEFLPGLWSSIRREVFQTASERVESAGLSALSSLVSCLSRSVLNSDSEDSLQVFLNLVLKSDCQHHLCEPDLKLVWPSAKLLQAAAGASYRASLIGTQAVIPALLDQYNNRTQCAQRRTLLEVLQGFVQPTPLSRPADGVSCISTHTHEEESVLVAFQQSLCTVVFSALSETSAGLQVTATRVLTALSQQPGLLSQTDVENAVDHLTRLILEEEEAQVSLAVVECSGSLAHLHPHAFVSRMIPQLKEKILSGRVHTVMEKTLSGSLYECSGAVRRRCVAALASVSSQPSVVQESSPVLLQVLTSAHTGCCGFSVEEVIAVCISLQRIAVHARDNEAIGQFFHDIIIPRLLGLTLQAALQSKDSGHISPLTDEAVLSAIVPVISTACAALKPESASRMAAQAVSLFLDGDTSFLPENAFPSQIQPLQSQADSRGPSQLVCLLMACVCSLPRSVEIPDMDRLLVQLEDLSCTSPHLFSYTFASKCIAGLVNKRPAGAALNAVLDRVLKRVSLELEETSSTHRTQAFTLLIWVAKALLLRYHPLSTALTDKLFSLLSDSALGSLVADGFCVLMNDSPDVLNRDCHADVRIMYRQRFFTENSSKLVQGFNSAEQAKKSCYLKALSHIVNNLPREVQLTELPALLPLLLEALSCVDQGVQLSTLSCLQPVLLESPAALNTQLEALFTRLLALTTSPAMKVRMASLRCVHALSRLPEHMVMPFRARVLKALAAPLDDKKRLVRKEAVAARGEWFLLGSPGG

mms19

MMS19 nucleotide excision repair protein homolog

1043 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.55 kDa

MAADNNVLLGLVEEFVSGQVDSKAADTSTGVKNGQFTVLQLVEALGVSLTSSQPQTRGRGVQLLSQVLQECYSGLSEREVEVLIAFYENRLKDHYVITPHVLRGLKALAKCSVLPPGSAVSILKSIFQDVHVQQQSLMVTERSCVYNILISLMESREEELKGLGADFIFGFVQSVDGERDPRNLLLAFQVAKNIIYRGYDLGKFVEELFEVTSCYFPIDFSPPPNDPHGITQEELILSLRAVLTGTPRFAEFLLPLIIEKMDSDVQSAKVDSMHTLAACGQTYSHKELAEFLPGLWSSIRREVFQTASERVESAGLSALSSLVSCLSRSVLNSDSEDSLQVFLNLVLKSDCQHHLCEPDLKLVWPSAKLLQAAAGASYRASLIGTQAVIPALLDQYNNRTQCAQRRTLLEVLQGFVQPTPLSRPADGVSCISTHTHEEESVLVAFQQSLCTVVFSALSETSAGLQVTATRVLTALSQQPGLLSQTDVENAVDHLTRLILEEEEAQVSLAVVECSGSLAHLHPHAFVSRMIPQLKEKILSGRVHTVMEKTLSGSLYECSGAVRRRCVAALASVSSQPSVVQESSPVLLQVLTSAHTGCCGFSVEEVIAVCISLQRIAVHARDNEAIGQFFHDIIIPRLLGLTLQAALQSKDSGHISPLTDEAVLSAIVPVISTACAALKPESASRMAAQAVSLFLDGDTSFLPENAFPSQIQPLQSQADSRGPSQLVCLLMACVCSLPRSVEIPDMDRLLVQLEDLSCTSPHLFSYTFASKCIAGLVNKRPAGAALNAVLDRVLKRVSLELEETSSTHRTQAFTLLIWVAKALLLRYHPLSTALTDKLFSLLSDSALGSLVADGFCVLMNDSPDVLNRDCHADVRIMYRQRFFTENSSKLVQGFNSAEQAKKSCYLKALSHIVNNLPREVQLTELPALLPLLLEALSCVDQGVQLSTLSCLQPVLLESPAALNTQLEALFTRLLALTTSPAMKVRMASLRCVHALSRLPEHMVMPFRARVLKALAAPLDDKKRLVRKEAVAARGEWFLLGSPGG

Mms19

MMS19 nucleotide excision repair protein homolog

1031 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Belongs to the MET18/MMS19 family.

113.089 kDa

MAAATGLEEAVAPMGALCGLVQDFVMGQQEGPADQVAADVKSGGYTVLQVVEALGSSLENAEPRTRARGAQLLSQVLLQCHSLLSEKEVVHLILFYENRLKDHHLVVPSVLQGLRALSMSVALPPGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMRSREEELKGLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYSLGPFVEELFEVTSCYFPIDFTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSCSVLRADAEDLLGSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACEHLTSNVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDRDERPLSSFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPGLLSAEDLELAVGHLYRLTFLEEDSQSCRVAALEASGTLATLYPGAFSRHLLPKLAEELHKGESDVARADGPTKCSRHFRCLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVTESSEVVAVCQSLQQVAEKCQQDPESYWYFHKTAVPCLFALAVQASMPEKESSVLRKVLLEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTSFLPENSFPDQFQPFQDGSSGQRRLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSCPFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLASESSRDQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSLHVDTLVTKFLNLSSSYSMAVRIAALQCMHALTRLPTSVLLPYKSQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

Mms19

MMS19 nucleotide excision repair protein homolog

1031 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Belongs to the MET18/MMS19 family.

113.089 kDa

MAAATGLEEAVAPMGALCGLVQDFVMGQQEGPADQVAADVKSGGYTVLQVVEALGSSLENAEPRTRARGAQLLSQVLLQCHSLLSEKEVVHLILFYENRLKDHHLVVPSVLQGLRALSMSVALPPGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMRSREEELKGLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYSLGPFVEELFEVTSCYFPIDFTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSCSVLRADAEDLLGSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACEHLTSNVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDRDERPLSSFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPGLLSAEDLELAVGHLYRLTFLEEDSQSCRVAALEASGTLATLYPGAFSRHLLPKLAEELHKGESDVARADGPTKCSRHFRCLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVTESSEVVAVCQSLQQVAEKCQQDPESYWYFHKTAVPCLFALAVQASMPEKESSVLRKVLLEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTSFLPENSFPDQFQPFQDGSSGQRRLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSCPFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLASESSRDQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSLHVDTLVTKFLNLSSSYSMAVRIAALQCMHALTRLPTSVLLPYKSQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

MMS19

MMS19 nucleotide excision repair protein homolog

1030 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Belongs to the MET18/MMS19 family.

113.112 kDa

MAAAAALEAVAPLGTLWGLVQDFVMGQQEGPADQVAADVKSGSYTVLQVVEALGSSLENPEPRTRARGIQLLSQVLLQCHSLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLRALSLCVTLPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYSIITNFMRAREEELKGLGADFTFGFIQVMDGEKDPRNLLVAFHIVYDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALNSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDHVTSNVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDKDERPLSGFKDQLCSLMFMALTDPNTQLQLVGIRTLTVLGAQPDLLSSGDLELAVGHLYRLSFLEEDSQSCRVAALEASGTLATLYPMAFSSHLVPRLAEDLCTEESDLARADGPTRCSRHPRCLQALSAISTHPSIVKETLPLLLQHLCQMNRGSVSPGTSEVIAVCQSLQQVAENCQRDPESCWYFHQTAVPCLLALVVQASAPEKEHSVLKKVLLEDEVLATMASVIATATTHLSPDLASQSVAHIVPLFLDGNISFLPENSFSGRFQPFQDGSSGQRRLVALLMAFVCSLPRNVEIPQLNRLMGELLELSCCQSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLSSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTERLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVRGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQVMSLHVDTLITKFLNLSASPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

MMS19

MMS19 nucleotide excision repair protein homolog

1030 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).

Belongs to the MET18/MMS19 family.

113.29 kDa

MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNYTVLQVVEALGSSLENPEPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLKALSLCVALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMRTREEELKSLGADFTFGFIQVMDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRRTILEMLLGFLKLQQKWSYEDKDQRPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPDLLSYEDLELAVGHLYRLSFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVPKLAEELRVGESNLTNGDEPTQCSRHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQSLRQMAEKCQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSVIGTATTHLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMAFVCSLPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFLNLSSSPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

MMS19

MMS19 nucleotide excision repair protein homolog

1030 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Belongs to the MET18/MMS19 family.

113.112 kDa

MAAAAALEAVAPLGTLWGLVQDFVMGQQEGPADQVAADVKSGSYTVLQVVEALGSSLENPEPRTRARGIQLLSQVLLQCHSLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLRALSLCVTLPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYSIITNFMRAREEELKGLGADFTFGFIQVMDGEKDPRNLLVAFHIVYDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALNSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDHVTSNVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDKDERPLSGFKDQLCSLMFMALTDPNTQLQLVGIRTLTVLGAQPDLLSSGDLELAVGHLYRLSFLEEDSQSCRVAALEASGTLATLYPMAFSSHLVPRLAEDLCTEESDLARADGPTRCSRHPRCLQALSAISTHPSIVKETLPLLLQHLCQMNRGSVSPGTSEVIAVCQSLQQVAENCQRDPESCWYFHQTAVPCLLALVVQASAPEKEHSVLKKVLLEDEVLATMASVIATATTHLSPDLASQSVAHIVPLFLDGNISFLPENSFSGRFQPFQDGSSGQRRLVALLMAFVCSLPRNVEIPQLNRLMGELLELSCCQSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLSSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTERLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVRGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQVMSLHVDTLITKFLNLSASPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

MMS19

MMS19 nucleotide excision repair protein homolog

1030 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).

Belongs to the MET18/MMS19 family.

113.29 kDa

MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNYTVLQVVEALGSSLENPEPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLKALSLCVALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMRTREEELKSLGADFTFGFIQVMDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRRTILEMLLGFLKLQQKWSYEDKDQRPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPDLLSYEDLELAVGHLYRLSFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVPKLAEELRVGESNLTNGDEPTQCSRHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQSLRQMAEKCQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSVIGTATTHLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMAFVCSLPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQLAVDKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADGFSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFLNLSSSPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS

mms19

MMS19 nucleotide excision repair protein homolog

1022 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.047 kDa

MAEAQTALWGLVEEFVVGEQDSKSAEVAAGVKDGVFTVLQVVESLGSCLANPEPRMRSKGVQLLSRVLLECYSRLTEKEVEVLVVFYENRLKDHHLITPHVLQGLMALSMCDVLPQGVAVSVLKSVFQEVHVQSLMQIDRHTVYMIITNFMKTREEELKNLGADFTYGFIQVMDGEKDPRNLLVAFYIVQDIVTKNYALGPFVEELFEVTSCYFPIDFTPPPSDPHGITREHLIMGLRAVLASTSRFAEFLLPLLIEKMDSEMQSAKLDSLQTLSACCTVYGQKELKEFLSGLWSSIRREVFQTASEKIEAEGLAALQALSACLSRSVLSPDAEDLLDSFLNNILQDCKHHLCEPDMKLVWPSAKLLQAAAGGSSRACWKVTANVLPLLLEQYNQHAQSSHRRTILEMTLGFLKLQSRWLDEEDENGLGNLKESLCSMVFSAVTDSSTQLHVVALKILTVLAMQQGFMASSDIDLVVDHLTRLILQKTDSESCMAAVEASGTLAKVHPSAFISRMLPQLCANLQTEPMDINLNESGVVPEHSIRQLCLEALAAVSTHQSILKETVPILLDYIRRAHNGEEETNVENVVSVCKSLHRVAVQCQLDSESLQFYHQTVLPCLLSLTVQAATQDSGTSSHILLRDDILTAMVPVISAACTHLKPELASKSTSQIVSLFLDGDISLLSENNFSSKFQPFQVNGPTELQNRLVSLLMAFICSLPRNVEIPHLRRLLQHLLSLSLSGCSLFAYSSASKCFAGLINKCPQGDLLDDILKVTAQRIDVGLVEEPSRTQAITLLVWVTKALVLRYHPLSGQLTDKMIGLLSDQQLGPSVANMFSLLVSDSPDILNKACHADIRIMFRQRFFTENVPKLVQGFNSANGDDKPNYLKALSHVLNTLPKQVLMPELPSLLSLLLEALSCPDKVVQLSTLICLEPLLQEAPETLKVHIDGLISKLLGLSCSPAMAVRITALKCILALTKLPLHMLLPYKQQVIRALAKPLDDKKRLVRKEAVETRCQWFLLGSPGS

mms19

MMS19 nucleotide excision repair protein homolog

1022 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.131 kDa

MAEAHSALWGLVEEFVVGEQDSRSAEVAAGVKDGIFTVLQVVEALGSCLANPEPRSRAKGMQLLSRVLLECYSRLTEKEVEVLVLFYENRLKDHHLITPHVLKGLMALSMCDVLPQGLAVSVLKSVFQEVHVQSLMQIDRHTVYMIITNFMKTREEELKSLGADFTYGFIQVMDGEKDPRNLLVAFHIVQDIITKNYALGPFVEELFEVTSCYFPIDFTPPPNDPHGITREHLIVGLRAVLVSTSRFAEFFLPLLIEKMDSDVQSAKLDSLQTLIACCTVYGQKDLKEFLSGLWSSIRREVFQTASEKIEAEGLAALQALSACLSRSILSPDAEDLLDSFLNSILQDCKHHLCEPDMKLVWPSAKLLQAAAGGSSRACWKVTANVLPLLLEQYNQHAQSSHRRTILEMTLGFLKLQSRWLDEEDDNGLGNLKEALCTMVFSAVTDSSTQLHQVAVRTLTVLAMQQGFLSSSDIDLVVDHLTRLILQETDSESCMAAIEASGTLAKVHPSVFISRMLPQLCANLQTEPMDINLNESRVVPERFIRQRCLEALAAVSTHQSILKETVPILLDYIGRVHNGEGETNAENVVSICRSLHRVAVQCQLDSEALQFYHEIVLPSLLSLTVQAATQDSGTSCNVLLRDDVLTAMVPVITAACTHLTPELASKSVSQVVALFLDGDVSLFSENNLPSNFQPFQVNGPTELQNHLVSLLMAFVCSLPRNVEIPHLRRLLQHLLSLSLSGCSPFAYSSASKCFAGLINKCPQGDLLDDILQVTAQRIDVGLVDEPSRTRAITLLVWVTKALVLRYHPLSGQLTNKMIGLLSDKQLGPSVANMFSLLVSDSPDIINKACHADIRIMFRQRFFTENVPKLVQGFNSANRDDKPNYLKALSHVLNALPKQVLMPELPSLLSLLLEALSCPDKVVQLSTLTCLEPLLQEAPETLKVHIDGLISKLVSLTLSPAMAVRITALKCILALTKLPLHMLLPYKQQVIRALAKPLDDKKRLVRKEAVETRCQWFLLGSPGS

mms19

MMS19 nucleotide excision repair protein homolog

1022 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.047 kDa

MAEAQTALWGLVEEFVVGEQDSKSAEVAAGVKDGVFTVLQVVESLGSCLANPEPRMRSKGVQLLSRVLLECYSRLTEKEVEVLVVFYENRLKDHHLITPHVLQGLMALSMCDVLPQGVAVSVLKSVFQEVHVQSLMQIDRHTVYMIITNFMKTREEELKNLGADFTYGFIQVMDGEKDPRNLLVAFYIVQDIVTKNYALGPFVEELFEVTSCYFPIDFTPPPSDPHGITREHLIMGLRAVLASTSRFAEFLLPLLIEKMDSEMQSAKLDSLQTLSACCTVYGQKELKEFLSGLWSSIRREVFQTASEKIEAEGLAALQALSACLSRSVLSPDAEDLLDSFLNNILQDCKHHLCEPDMKLVWPSAKLLQAAAGGSSRACWKVTANVLPLLLEQYNQHAQSSHRRTILEMTLGFLKLQSRWLDEEDENGLGNLKESLCSMVFSAVTDSSTQLHVVALKILTVLAMQQGFMASSDIDLVVDHLTRLILQKTDSESCMAAVEASGTLAKVHPSAFISRMLPQLCANLQTEPMDINLNESGVVPEHSIRQLCLEALAAVSTHQSILKETVPILLDYIRRAHNGEEETNVENVVSVCKSLHRVAVQCQLDSESLQFYHQTVLPCLLSLTVQAATQDSGTSSHILLRDDILTAMVPVISAACTHLKPELASKSTSQIVSLFLDGDISLLSENNFSSKFQPFQVNGPTELQNRLVSLLMAFICSLPRNVEIPHLRRLLQHLLSLSLSGCSLFAYSSASKCFAGLINKCPQGDLLDDILKVTAQRIDVGLVEEPSRTQAITLLVWVTKALVLRYHPLSGQLTDKMIGLLSDQQLGPSVANMFSLLVSDSPDILNKACHADIRIMFRQRFFTENVPKLVQGFNSANGDDKPNYLKALSHVLNTLPKQVLMPELPSLLSLLLEALSCPDKVVQLSTLICLEPLLQEAPETLKVHIDGLISKLLGLSCSPAMAVRITALKCILALTKLPLHMLLPYKQQVIRALAKPLDDKKRLVRKEAVETRCQWFLLGSPGS

mms19

MMS19 nucleotide excision repair protein homolog

1022 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity).

Belongs to the MET18/MMS19 family.

113.131 kDa

MAEAHSALWGLVEEFVVGEQDSRSAEVAAGVKDGIFTVLQVVEALGSCLANPEPRSRAKGMQLLSRVLLECYSRLTEKEVEVLVLFYENRLKDHHLITPHVLKGLMALSMCDVLPQGLAVSVLKSVFQEVHVQSLMQIDRHTVYMIITNFMKTREEELKSLGADFTYGFIQVMDGEKDPRNLLVAFHIVQDIITKNYALGPFVEELFEVTSCYFPIDFTPPPNDPHGITREHLIVGLRAVLVSTSRFAEFFLPLLIEKMDSDVQSAKLDSLQTLIACCTVYGQKDLKEFLSGLWSSIRREVFQTASEKIEAEGLAALQALSACLSRSILSPDAEDLLDSFLNSILQDCKHHLCEPDMKLVWPSAKLLQAAAGGSSRACWKVTANVLPLLLEQYNQHAQSSHRRTILEMTLGFLKLQSRWLDEEDDNGLGNLKEALCTMVFSAVTDSSTQLHQVAVRTLTVLAMQQGFLSSSDIDLVVDHLTRLILQETDSESCMAAIEASGTLAKVHPSVFISRMLPQLCANLQTEPMDINLNESRVVPERFIRQRCLEALAAVSTHQSILKETVPILLDYIGRVHNGEGETNAENVVSICRSLHRVAVQCQLDSEALQFYHEIVLPSLLSLTVQAATQDSGTSCNVLLRDDVLTAMVPVITAACTHLTPELASKSVSQVVALFLDGDVSLFSENNLPSNFQPFQVNGPTELQNHLVSLLMAFVCSLPRNVEIPHLRRLLQHLLSLSLSGCSPFAYSSASKCFAGLINKCPQGDLLDDILQVTAQRIDVGLVDEPSRTRAITLLVWVTKALVLRYHPLSGQLTNKMIGLLSDKQLGPSVANMFSLLVSDSPDIINKACHADIRIMFRQRFFTENVPKLVQGFNSANRDDKPNYLKALSHVLNALPKQVLMPELPSLLSLLLEALSCPDKVVQLSTLTCLEPLLQEAPETLKVHIDGLISKLVSLTLSPAMAVRITALKCILALTKLPLHMLLPYKQQVIRALAKPLDDKKRLVRKEAVETRCQWFLLGSPGS

mms19

DNA repair/transcription protein mms19

1018 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as rad3/xpd and dna2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription (By similarity).

Belongs to the MET18/MMS19 family.

114.67 kDa

MSSNLVALYLFSIDRSQDEANDVVDRIVEEIVTDRMGIVDLVTSIGEYLTDNNISVRAKAVLLLSQTLGELPKDRLPAKHVSVLLQFYLSRLDDEVTMKENALGIGALLNMQNFPAQKIVDVCKALFSSTDMPKYAQATRLNILKVFETIIDNYLFFISSQTRDAFFSGICSTFAGEKDPRNLMLVFSMLKKILSTFPIDGFEQQFFDITYCYFPITFRAPPDATNLAITSDDLKIALRETLVANDAFSKLLLPALFERLKASTVRIKIDALNIYIEACKTWRVGAYLWSAKDFWESIKQEILNSTDAELQNLALGALNTLASKFYKEEGFSSSFTEFVDMILIQLSQRLLEDVNVKSCGSCAAVFASLASISVETFNYCSCNFLPSVLDLPMVNEPLEKQKGMLVFLEYVYKCLVLLYGKWRSKNQADIDNPLLVYKDKQLSFVSGSLMGTAKDETEIRMLALKVIFLMASIKNFLTESELTMVLQFLDDIAFDFSDPIKKKATECLKDLGLLKPDFLLLTSFPFAFSKLTDDVTAKSSSEETFKQYLSVLVSISEERSLFKALVIRLVEMLKDQFKSKEMSVDLVESIVQSLSVAFKERNDRNEQEIPFFFEELLKQLFTLCFANCESMNVRCLIYVSQTINEIVRVNHFEFQEKFVGQLWKLYMENSNSDLIETEGCEKAAERFTLAASLSDQKFLNLVVLLQGGLNGLSKKLHFIEKLNIELLNLLINVVFVTESPGVKISALRLISSLINKCEKDEDISSFISSKGVTSLWDKVYTGTPKESEAALDVLAWVDKALVSRKHSEGIPLAFKLLDTLNLQNVGDSSVKALSIIIKDDPALSKENSYVEKLLYKQRFYASVSPKILEHISTATGGEKSLYLMLLSNVIGNVPKEIVIPDMPSILPLLLQCLSLSDISVKLSTLNVIHTSVKELTSLLTEYLDTLIPSLLAIPKDMNNPTVVRLLALKCLGSLPEFTPTTNLQLFRDKVIRGLIPCLDDPKRVVRTEASRTRHKWYI

mms19

DNA repair/transcription protein mms19

1018 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as rad3/xpd and dna2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription (By similarity).

Belongs to the MET18/MMS19 family.

114.67 kDa

MSSNLVALYLFSIDRSQDEANDVVDRIVEEIVTDRMGIVDLVTSIGEYLTDNNISVRAKAVLLLSQTLGELPKDRLPAKHVSVLLQFYLSRLDDEVTMKENALGIGALLNMQNFPAQKIVDVCKALFSSTDMPKYAQATRLNILKVFETIIDNYLFFISSQTRDAFFSGICSTFAGEKDPRNLMLVFSMLKKILSTFPIDGFEQQFFDITYCYFPITFRAPPDATNLAITSDDLKIALRETLVANDAFSKLLLPALFERLKASTVRIKIDALNIYIEACKTWRVGAYLWSAKDFWESIKQEILNSTDAELQNLALGALNTLASKFYKEEGFSSSFTEFVDMILIQLSQRLLEDVNVKSCGSCAAVFASLASISVETFNYCSCNFLPSVLDLPMVNEPLEKQKGMLVFLEYVYKCLVLLYGKWRSKNQADIDNPLLVYKDKQLSFVSGSLMGTAKDETEIRMLALKVIFLMASIKNFLTESELTMVLQFLDDIAFDFSDPIKKKATECLKDLGLLKPDFLLLTSFPFAFSKLTDDVTAKSSSEETFKQYLSVLVSISEERSLFKALVIRLVEMLKDQFKSKEMSVDLVESIVQSLSVAFKERNDRNEQEIPFFFEELLKQLFTLCFANCESMNVRCLIYVSQTINEIVRVNHFEFQEKFVGQLWKLYMENSNSDLIETEGCEKAAERFTLAASLSDQKFLNLVVLLQGGLNGLSKKLHFIEKLNIELLNLLINVVFVTESPGVKISALRLISSLINKCEKDEDISSFISSKGVTSLWDKVYTGTPKESEAALDVLAWVDKALVSRKHSEGIPLAFKLLDTLNLQNVGDSSVKALSIIIKDDPALSKENSYVEKLLYKQRFYASVSPKILEHISTATGGEKSLYLMLLSNVIGNVPKEIVIPDMPSILPLLLQCLSLSDISVKLSTLNVIHTSVKELTSLLTEYLDTLIPSLLAIPKDMNNPTVVRLLALKCLGSLPEFTPTTNLQLFRDKVIRGLIPCLDDPKRVVRTEASRTRHKWYI