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MMADHC

Gene
MMADHC
Protein
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
Organism
Gallus gallus
Length
296 amino acids
Function
Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC.
Mass
33.131 kDa
Sequence
MANVLCNRARLVTYLPGFYSLVKRVVNPKAFSTAGSSGSDEPHVAATPPDLCPRTVWPDEVMGPFGPQDQRFQLPGNIGFDCHLNGTAAQRKSQASKSLPDILAEPSPNERHEFVMAQYINEFQGSDVPQKQQVNNAETYFENAKVECAVQACPELLRKDFESMFPEVNANHLTVLTVTQKTKNDMTVWSQEVEDEREMLLENFINGAKEICYAICSEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHFGFSVDDLGCCKVIRHNIWGTHVVVGSIFTNAEPDSPIMRKLSGN

Gene
MMADHC
Protein
Methylmalonic aciduria and homocystinuria type D protein, mitochondrial
Organism
Homo sapiens
Length
296 amino acids
Function
Involved in cobalamin metabolism (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin (PubMed:18385497, PubMed:24722857). Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin (PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851).
Mass
32.94 kDa
Sequence
MANVLCNRARLVSYLPGFCSLVKRVVNPKAFSTAGSSGSDESHVAAAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSLVHKTLPDVLAEPLSSERHEFVMAQYVNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPEVANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN

Gene
Mmadhc
Protein
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
Organism
Mus musculus
Length
296 amino acids
Function
Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC.
Mass
32.995 kDa
Sequence
MAHVLCNRARLVSYLPGFCSLVKRVINPRAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSQAHKTLPDVLAEPLSTERHEFVMAQYVNEFQDSDAPVEQEINSAETYFESAKVECAIQTCPELLRRDFESLFPEVANSKLMILTVTQKTENDMTVWSEEVEVEREVLLEKFISGAKEICYALRAEGYWADFIDPSSGVAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATADSSIMRKLSGN

Gene
Mmadhc
Protein
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
Organism
Rattus norvegicus
Length
296 amino acids
Function
Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC.
Mass
33.052 kDa
Sequence
MAHVLCNRARLVSYLPGFCSLVKRVINPRAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSQAHKTLPDVLAEPLSTERHEFVMAQYVNEFQDSNAPVEQEISSAETYFESARVECAIQTCPELLRRDFESLFPEVANSKLMILTVTQKTEHDMTVWSEEVEVEREALLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHGLWGTHVVVGSIFTNATADSHIMRKLSGD