MMAA

Methylmalonic aciduria type A protein, mitochondrial

418 amino acids

GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis (PubMed:28497574, PubMed:20876572).

Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

46.538 kDa

MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDGLKRKLCVQTTLKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQVLLQKVLLYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGAGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAVTKSDGDLIVPARRIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLMLASGELTAKRRKQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD

Mmaa

Methylmalonic aciduria type A homolog, mitochondrial

415 amino acids

GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis.

Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

45.932 kDa

MTISTLLLSPNRRLLTCLSRVPSPWLLHSSHPAPGPPGALPNCFGHHCTKRVLLSDGFRRTLCVQATLKDHTEGLSDKEQRFVDRLYTGLVKGQRACLAEAITLVESTHTRKRELAQVLLQRVLALQREQELRNQGKPLTFRVGLSGPPGAGKSTFIECFGKMLTEQGHRLSVLAVDPSSCTSGGSLLGDKTRMIELSRDMNAYIRPSPTSGTLGGVTRTTNEAIVLCEGGGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVVITKSDGDLIVPARRIQAEYVSALKLLRRRSEVWRPKVIRISARSGEGITEMWDTMREFQHQMLASGELAAKRQTQHKVWMWNLIQENVLEHFKTHPSIREQIPLMERKVLSGALSPGRAADLLLKAFKSRH

MMAA

Methylmalonic aciduria type A homolog, mitochondrial

413 amino acids

GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis.

Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

45.682 kDa

MAMLLPHPHPDFLKGLLKAPFRCYRFIFHSSTHLGSGIPCAQPFNLLGLHYAKWMLLSDGLKRNLCVQTTLKDHKEGLSDKGQRFVDKLFTGLIQGQRACLAEAKTLVESTHSRKKELAQVLLQKVLLFQREQEQPNKGNPLAFRLGLSGPPGAGKSTFIEYSGKLLTERGHKLSVLAVGPSSCNSGGSLLGDKTRMTEFSRDMNAYIRPSPTRGNLGGVPRTTNEVILLCEGAGYDIILIETVGVGQSEFAVADTVDILFYYCHQLEEMNCRVSKEVYLRWQHGSNNYVCWRLDCASSKDTGRVCDALKLLRRRLAVWRPKVVRISARSWRGGHWNVGYDARILGPNTCQRGAACQTTKATESLDVEPHSGKRVRAFQESPHSPGADSCSGTKGPPWGPGPRASSRFVVEGF