Protein
Putative threonylcarbamoyl-AMP synthase
Organism
Mycobacterium leprae (strain TN)
Function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Similarity
Belongs to the SUA5 family.
Sequence
MVRMNEVFDCADPDQRARGIASAVAALKGGRLVVMPTDTVYGIGADAFDRAAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYTMPDGARELIRAFWPGALSLVVVHAPSLNWDLGDAHGTVMLRMPLHSVAIELLCEVGPMAVSSANVSGQPAAVDVDGARGQLGELVGVYLDAGPSAQQAASTIVDLTEATPRILRAGPVSVARIAEVLGVVPASLIA